G6pc1 glucose-6-phosphatase catalytic subunit 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: G6pc1provided by MGI
Official Full Name: glucose-6-phosphatase catalytic subunit 1provided by MGI
Primary source: MGI:MGI:95607
See related: Ensembl:ENSMUSG00000078650 AllianceGenome:MGI:95607
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: G6pc; G6pt; G6Pase; Glc-6-Pase
Summary: The enzyme encoded by this gene is a multisubunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for glucose-6-phosphate, inorganic phosphate, and glucose. This gene is one of three glucose-6-phosphatase catalytic-subunit-encoding genes in mouse. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). [provided by RefSeq, Sep 2015]
Expression: Biased expression in kidney adult (RPKM 142.5), liver adult (RPKM 58.4) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 64.83 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (101258542..101268729)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (101367716..101377903)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

G6PC1 and G6PC2 influence G6P flux but not HSD11B1 activity.
Title: G6PC1 and G6PC2 influence G6P flux but not HSD11B1 activity.
A caveolin-1 dependent glucose-6-phosphatase trafficking contributes to hepatic glucose production.
Title: A caveolin-1 dependent glucose-6-phosphatase trafficking contributes to hepatic glucose production.
Hepatocyte-specific glucose-6-phosphatase deficiency disturbs platelet aggregation and decreases blood monocytes upon fasting-induced hypoglycemia.
Title: Hepatocyte-specific glucose-6-phosphatase deficiency disturbs platelet aggregation and decreases blood monocytes upon fasting-induced hypoglycemia.
Correction of metabolic abnormalities in a mouse model of glycogen storage disease type Ia by CRISPR/Cas9-based gene editing.
Title: Correction of metabolic abnormalities in a mouse model of glycogen storage disease type Ia by CRISPR/Cas9-based gene editing.
The absence of hepatic glucose-6 phosphatase/ChREBP couple is incompatible with survival in mice.
Title: The absence of hepatic glucose-6 phosphatase/ChREBP couple is incompatible with survival in mice.
The results reveal a previously unrecognized physiological function of NFYA in controlling glucose metabolism by up-regulating the gluconeogenic genes Pck1 and G6pc.
Title: Regulation of hepatic gluconeogenesis by nuclear factor Y transcription factor in mice.
Hepatic mitochondrial dysfunction is a feature of glycogen storage disease type Ia with glucose-6-phosphatase deficiency.
Title: Hepatic mitochondrial dysfunction is a feature of Glycogen Storage Disease Type Ia (GSDIa).
hepatic G6Pase-alpha deficiency causes metabolic reprogramming, leading to enhanced glycolysis and elevated hexose monophosphate shunt that along with impaired autophagy can contribute to hepatocellular adenoma/carcinoma development in glycogen storage disease type Ia.
Title: Hepatic glucose-6-phosphatase-α deficiency leads to metabolic reprogramming in glycogen storage disease type Ia.
We envisage these data and models finding utility when investigating the muscle-specific functions of the 11beta-HSD1/G6PT/H6PDH triad.
Title: Cellular and genetic models of H6PDH and 11β-HSD1 function in skeletal muscle.
Data show that glucose-6-phosphatase and perilipin-5 (G6PC/PLIN5) are upregulated in notch1 knockout (KO) mice.
Title: Hepatic Notch1 deletion predisposes to diabetes and steatosis via glucose-6-phosphatase and perilipin-5 upregulation.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G6pc (e-PCR), detects polymorphism
- UniSTS:461917

AW107337 (e-PCR)
- UniSTS:180324

PMC86435P4 (e-PCR)
- UniSTS:273526

PMC209474P1 (e-PCR)
- UniSTS:271997

G6pc (e-PCR), detects polymorphism
- UniSTS:256669

U00445 (e-PCR)
- UniSTS:160163

G6pc (e-PCR), detects polymorphism
- UniSTS:526039

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables glucose-6-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucose-6-phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables glucose-6-phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glucose-6-phosphatase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables phosphate ion binding	ISO Inferred from Sequence Orthology more info
enables phosphotransferase activity, alcohol group as acceptor	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cholesterol homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gluconeogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in gluconeogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gluconeogenesis	ISO Inferred from Sequence Orthology more info
involved_in glucose 6-phosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glucose 6-phosphate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose 6-phosphate metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose-6-phosphate transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within glucose-6-phosphate transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glycogen catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glycogen metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within steroid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within triglyceride metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within urate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glucose-6-phosphatase catalytic subunit 1

Names: Glc-6-Pase-alpha; glucose-6-phosphatase, catalytic

NP_032087.2

EC 3.1.3.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008061.4 → NP_032087.2 glucose-6-phosphatase catalytic subunit 1

See identical proteins and their annotated locations for NP_032087.2

Status: REVIEWED

Source sequence(s)

AA238078, AK050279

Consensus CDS

CCDS25466.1

UniProtKB/Swiss-Prot

P35576, Q91WV3

Related

ENSMUSP00000019469.3, ENSMUST00000019469.3

Conserved Domains (2) summary

COG0671
Location:41 → 192

PgpB; Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]

cd03381
Location:42 → 280

PAP2_glucose_6_phosphatase; PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts glucose-6-phosphate into free glucose and is active in the lumen of the endoplasmic reticulum, where it is bound to the membrane. The generation of free glucose is an ...