Fzd5 frizzled class receptor 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fzd5provided by MGI
Official Full Name: frizzled class receptor 5provided by MGI
Primary source: MGI:MGI:108571
See related: Ensembl:ENSMUSG00000045005 AllianceGenome:MGI:108571
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fz5; Fz-5; mFz5; 5330434N09Rik
Summary: Enables Wnt-protein binding activity. Involved in camera-type eye development; canonical Wnt signaling pathway; and positive regulation of cytokine production. Acts upstream of or within several processes, including chorionic trophoblast cell differentiation; embryonic organ development; and positive regulation of nitrogen compound metabolic process. Located in several cellular components, including Golgi apparatus; bicellular tight junction; and perinuclear region of cytoplasm. Colocalizes with early endosome. Is expressed in several structures, including alimentary system; early conceptus; future brain; genitourinary system; and sensory organ. Orthologous to human FZD5 (frizzled class receptor 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in colon adult (RPKM 30.4), large intestine adult (RPKM 20.0) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C2; 1 32.74 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (64769717..64776907, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (64730558..64737750, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Age and light damage influence Fzd5 regulation of ocular growth-related genes.
Title: Age and light damage influence Fzd5 regulation of ocular growth-related genes.
Sfrp2 promotes renal dysfunction of diabetic kidney disease via modulating Fzd5-induced cytosolic calcium ion concentration and CaMKII/Mek/Erk pathway in mesangial cells.
Title: Sfrp2 promotes renal dysfunction of diabetic kidney disease via modulating Fzd5-induced cytosolic calcium ion concentration and CaMKII/Mek/Erk pathway in mesangial cells.
Axonal transport of Frizzled5 by Alcadein alpha-containing vesicles is associated with kinesin-1.
Title: Axonal transport of Frizzled5 by Alcadein α-containing vesicles is associated with kinesin-1.
Single-Cell Characterization of the Frizzled 5 (Fz5) Mutant Mouse and Human Persistent Fetal Vasculature (PFV).
Title: Single-Cell Characterization of the Frizzled 5 (Fz5) Mutant Mouse and Human Persistent Fetal Vasculature (PFV).
Wingless-type MMTV integration site family member 5a is a key inhibitor of islet stellate cells activation.
Title: Wingless-type MMTV integration site family member 5a is a key inhibitor of islet stellate cells activation.
FZD5 is a receptor for SFRP2 and mediates SFRP2-induced angiogenesis via calcineurin/NFATc3 pathway in endothelial cells.
Title: Frizzled-5: a high affinity receptor for secreted frizzled-related protein-2 activation of nuclear factor of activated T-cells c3 signaling to promote angiogenesis.
Frizzled-5, showed a clear up-regulation at late stages in ALS neurons. Increased Frizzled-5 appears to correlate with a decrease in NeuN signal in these cells, suggesting a correlation between neuronal affectation and the increased expression of this receptor.
Title: Wnt Signaling Alteration in the Spinal Cord of Amyotrophic Lateral Sclerosis Transgenic Mice: Special Focus on Frizzled-5 Cellular Expression Pattern.
Adra2a is expressed in the mesenchyme of the mouse stomach primordium at E11.5. Fzd5 and Trpv6 are expressed in the epithelial layer of the stomach primordium after E11.5.
Title: Novel cell surface genes expressed in the stomach primordium during gastrointestinal morphogenesis of mouse embryos.
Fzd5 and Trvp6 are expressed in the epithelial layer of the prospective pyroric and glandular stomach, respectively and Adra2a is expressed in the mesenchymal region of the stomach primordium at the beginning of morphogenesis.
Title: Novel cell surface genes expressed in the stomach primordium during gastrointestinal morphogenesis of mouse embryos.
we demonstrate that innate immune functions of macrophages ensue at least partly through a homeostatic Wnt5a-Fz5-NF-kappaB (p65) circuit, which is Rac1 dependent.
Title: Wnt5a-Rac1-NF-κB homeostatic circuitry sustains innate immune functions in macrophages.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Fzd5 (e-PCR), detects polymorphism
- UniSTS:506911

AI427138 (e-PCR)
- UniSTS:158800

Fzd5 (e-PCR), detects polymorphism
- UniSTS:516478

Fzd5 (e-PCR), detects polymorphism
- UniSTS:508389

NoName (e-PCR)
- UniSTS:548582

Fzd5 (e-PCR), detects polymorphism
- UniSTS:508390

Fzd5 (e-PCR), detects polymorphism
- UniSTS:547566

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables Wnt receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt receptor activity	ISO Inferred from Sequence Orthology more info
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt-protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables Wnt-protein binding	ISO Inferred from Sequence Orthology more info
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Spemann organizer formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T cell differentiation in thymus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anterior/posterior axis specification, embryo	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apoptotic process involved in morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within branching involved in labyrinthine layer morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to molecule of bacterial origin	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chorionic trophoblast cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic axis specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic camera-type eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic camera-type eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glandular epithelial cell maturation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intestinal epithelial cell maturation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within labyrinthine layer blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in non-canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of JUN kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of T cell cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 beta production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-embryonic camera-type eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-embryonic camera-type eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in presynapse assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of bicellular tight junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of chorionic trophoblast cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within syncytiotrophoblast cell differentiation involved in labyrinthine layer development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in bicellular tight junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
colocalizes_with early endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: frizzled-5

Names: frizzled homolog 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001042659.2 → NP_001036124.1 frizzled-5 precursor

See identical proteins and their annotated locations for NP_001036124.1

Status: VALIDATED

Source sequence(s)

AC101915

Consensus CDS

CCDS15008.1

UniProtKB/Swiss-Prot

G5E8F0, O08975, Q8BMR2, Q8CHK9, Q9EQD0

UniProtKB/TrEMBL

Q149L3

Related

ENSMUSP00000111828.3, ENSMUST00000116133.4

Conserved Domains (3) summary

cd07460
Location:29 → 156

CRD_FZ5; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 5 (Fz5) receptor.proteins

cd14964
Location:235 → 259

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:225 → 535

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_022721.4 → NP_073558.2 frizzled-5 precursor

See identical proteins and their annotated locations for NP_073558.2

Status: VALIDATED

Source sequence(s)

AC101915

Consensus CDS

CCDS15008.1

UniProtKB/Swiss-Prot

G5E8F0, O08975, Q8BMR2, Q8CHK9, Q9EQD0

UniProtKB/TrEMBL

Q149L3

Related

ENSMUSP00000067783.6, ENSMUST00000063982.7

Conserved Domains (3) summary

cd07460
Location:29 → 156

CRD_FZ5; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 5 (Fz5) receptor.proteins

cd14964
Location:235 → 259

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:225 → 535

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily