Flot1 flotillin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Flot1provided by MGI
Official Full Name: flotillin 1provided by MGI
Primary source: MGI:MGI:1100500
See related: Ensembl:ENSMUSG00000059714 AllianceGenome:MGI:1100500
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: reggie-2
Summary: Predicted to enable ionotropic glutamate receptor binding activity and protease binding activity. Involved in several processes, including positive regulation of cell-cell adhesion mediated by cadherin; positive regulation of cellular component organization; and positive regulation of dopaminergic synaptic transmission. Acts upstream of or within axonogenesis; protein localization to plasma membrane; and regulation of Rho protein signal transduction. Located in caveola; external side of plasma membrane; and sarcolemma. Part of flotillin complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human FLOT1 (flotillin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bladder adult (RPKM 47.3), heart adult (RPKM 42.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 18.7 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (36134243..36143674)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (35823320..35832789)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Flot1 plays a detectable but unexpectedly minor role for CD8(+) T cell behavior under physiological conditions.
Title: In Vivo Function of the Lipid Raft Protein Flotillin-1 during CD8(+) T Cell-Mediated Host Surveillance.
the presence of Flotillin-1, in addition to Flotillin-2 in the cardiac intercalated disc, is reported.
Title: Flotillins in the intercalated disc are potential modulators of cardiac excitability.
Genetic Flot1 depletion augments chronic corticosterone-induced behavioral despair. Flot-1 interacts with serotonin transporter.
Title: Flotillin-1 interacts with the serotonin transporter and modulates chronic corticosterone response.
FLOT1 is a novel participant in the disposal of harmful remant lipoproteins via syndecan-1. Low expression of FLOT1 in T2DM liver may contribute to metabolic dyslipoproteinemia.
Title: Suppression of Hepatic FLOT1 (Flotillin-1) by Type 2 Diabetes Mellitus Impairs the Disposal of Remnant Lipoproteins via Syndecan-1.
flotillins may directly or indirectly regulate cellular sphingolipid distribution and signaling by maintaining S1P levels
Title: Flotillin proteins recruit sphingosine to membranes and maintain cellular sphingosine-1-phosphate levels.
DJ-1 has a role in glutamate uptake into astrocytes by regulating flotillin-1 and caveolin-1 expression
Title: DJ-1 deficiency impairs glutamate uptake into astrocytes via the regulation of flotillin-1 and caveolin-1 expression.
flotillin has a role in desmosomal adhesion and Pemphigus vulgaris-like localisation of desmoglein-3 in human keratinocytes
Title: Loss of flotillin expression results in weakened desmosomal adhesion and Pemphigus vulgaris-like localisation of desmoglein-3 in human keratinocytes.
an involvement of LRAP in lipid-raft-dependent signaling pathways are mediated by flotillin-1.
Title: Leucine-Rich Amelogenin Peptide (LRAP) Uptake by Cementoblast Requires Flotillin-1 Mediated Endocytosis.
Findings suggest that FLOT1 plays an important role in the proliferation and recurrence of transitional cell carcinoma.
Title: Overexpression of flotillin-1 is involved in proliferation and recurrence of bladder transitional cell carcinoma.
Downregulation of microRNA-182-5p contributes to renal cell carcinoma proliferation via activating the AKT/FOXO3a signaling pathway with FLOT1 being a target.
Title: Downregulation of microRNA-182-5p contributes to renal cell carcinoma proliferation via activating the AKT/FOXO3a signaling pathway.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Flot1 (e-PCR), detects polymorphism
- UniSTS:506895

RH136199 (e-PCR)
- UniSTS:210194

MARC_5855-5856:997299371:1 (e-PCR)
- UniSTS:269590

UniSTS:496739 (e-PCR)
- UniSTS:496739

Ier3 (e-PCR), detects polymorphism
- UniSTS:496739

U90435 (e-PCR)
- UniSTS:160654

RH12614 (e-PCR)
- UniSTS:43448

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ionotropic glutamate receptor binding	ISO Inferred from Sequence Orthology more info
enables protease binding	IBA Inferred from Biological aspect of Ancestor more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within axon guidance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to exogenous dsRNA	ISO Inferred from Sequence Orthology more info
involved_in dsRNA transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endocytosis	ISO Inferred from Sequence Orthology more info
involved_in extracellular matrix disassembly	ISO Inferred from Sequence Orthology more info
involved_in plasma membrane raft assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect plasma membrane raft organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell junction assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell junction assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-cell adhesion mediated by cadherin	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell-cell adhesion mediated by cadherin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell-cell adhesion mediated by cadherin	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interferon-beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myoblast fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of myoblast fusion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein binding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein binding	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of skeletal muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of skeletal muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission, dopaminergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of toll-like receptor 3 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein kinase C signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein kinase C signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein kinase C signaling	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of Rho protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neurotransmitter uptake	ISO Inferred from Sequence Orthology more info
involved_in regulation of receptor internalization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of receptor internalization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of COP9 signalosome	ISO Inferred from Sequence Orthology more info
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in caveola	IDA Inferred from Direct Assay more info	PubMed
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in cell-cell contact zone	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
colocalizes_with cortical actin cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in dopaminergic synapse	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of flotillin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of flotillin complex	IDA Inferred from Direct Assay more info	PubMed
part_of flotillin complex	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in microtubule organizing center	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane raft	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	ISO Inferred from Sequence Orthology more info
located_in uropod	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: flotillin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001410113.1 → NP_001397042.1 flotillin-1 isoform 1

Status: VALIDATED

Source sequence(s)

CR974451

UniProtKB/Swiss-Prot

O08917

UniProtKB/TrEMBL

Q540I4
NM_001410114.1 → NP_001397043.1 flotillin-1 isoform 1

Status: VALIDATED

Source sequence(s)

CR974451

UniProtKB/Swiss-Prot

O08917

UniProtKB/TrEMBL

Q540I4
NM_001410115.1 → NP_001397044.1 flotillin-1 isoform 1

Status: VALIDATED

Source sequence(s)

CR974451

UniProtKB/Swiss-Prot

O08917

UniProtKB/TrEMBL

Q540I4
NM_001410116.1 → NP_001397045.1 flotillin-1 isoform 1

Status: VALIDATED

Source sequence(s)

CR974451

UniProtKB/Swiss-Prot

O08917

UniProtKB/TrEMBL

Q540I4
NM_001410117.1 → NP_001397046.1 flotillin-1 isoform 2

Status: VALIDATED

Source sequence(s)

CR974451
NM_001410118.1 → NP_001397047.1 flotillin-1 isoform 5

Status: VALIDATED

Source sequence(s)

CR974451
NM_001410119.1 → NP_001397048.1 flotillin-1 isoform 3

Status: VALIDATED

Source sequence(s)

CR974451
NM_001410121.1 → NP_001397050.1 flotillin-1 isoform 7

Status: VALIDATED

Source sequence(s)

CR974451
NM_001410122.1 → NP_001397051.1 flotillin-1 isoform 8

Status: VALIDATED

Source sequence(s)

CR974451
NM_001410125.1 → NP_001397054.1 flotillin-1 isoform 6

Status: VALIDATED

Source sequence(s)

CR974451
NM_001410126.1 → NP_001397055.1 flotillin-1 isoform 6

Status: VALIDATED

Source sequence(s)

CR974451
NM_001410127.1 → NP_001397056.1 flotillin-1 isoform 4

Status: VALIDATED

Source sequence(s)

CR974451
NM_008027.3 → NP_032053.1 flotillin-1 isoform 1

See identical proteins and their annotated locations for NP_032053.1

Status: VALIDATED

Source sequence(s)

CR974451

Consensus CDS

CCDS28705.1

UniProtKB/Swiss-Prot

O08917

UniProtKB/TrEMBL

Q3TJS0, Q540I4

Related

ENSMUSP00000001569.9, ENSMUST00000001569.15

Conserved Domains (2) summary

COG2268
Location:4 → 424

YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]

cd03399
Location:30 → 175

SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily