Vegfd vascular endothelial growth factor D [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Vegfdprovided by MGI
Official Full Name: vascular endothelial growth factor Dprovided by MGI
Primary source: MGI:MGI:108037
See related: Ensembl:ENSMUSG00000031380 AllianceGenome:MGI:108037
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Figf; VEGF-D
Summary: This gene encodes a member of the vascular endothelial growth factor (VEGF) family that acts as a ligand for vascular endothelial growth factor receptor 3. Signalling through this protein is important for growth and development of endothelial and vascular tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
Expression: Broad expression in lung adult (RPKM 6.5), adrenal adult (RPKM 5.0) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: X F5; X 76.35 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (163156282..163185643)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (164373522..164402650)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

VEGF-D Downregulation in CA1 Pyramidal Neurons Exerts Asymmetric Changes of Dendritic Morphology without Correlated Electrophysiological Alterations.
Title: VEGF-D Downregulation in CA1 Pyramidal Neurons Exerts Asymmetric Changes of Dendritic Morphology without Correlated Electrophysiological Alterations.
Here, we observed that treatment with Ad-FIGF was found to enhance MafA and Ngn3-induced reprogramming of BNL CL.2 cells to beta-like cells with the ability of secreting insulin.
Title: Effect of FIGF overexpression on liver cells transforming to insulin-producing cells.
VEGF-D, a powerful lymphangiogenic and angiogenic growth factor, is also a major regulator of chylomicron metabolism in mice.
Title: Deletion of Lymphangiogenic and Angiogenic Growth Factor VEGF-D Leads to Severe Hyperlipidemia and Delayed Clearance of Chylomicron Remnants.
results identify HDAC4 as an epigenetic regulator of neuronal morphology that controls dendritic arborization via the expression of VEGFD
Title: Histone deacetylase 4 shapes neuronal morphology via a mechanism involving regulation of expression of vascular endothelial growth factor D.
lymphangiogenesis is regulated by two distinct proteolytic mechanisms of ligand activation: one in which VEGFC activation by ADAMTS3 and CCBE1 spatially and temporally patterns developing lymphatics, and one in which VEGFD activation by a distinct proteolytic mechanism may be stimulated during inflammatory lymphatic growth
Title: Proteolytic activation defines distinct lymphangiogenic mechanisms for VEGFC and VEGFD.
This study uncovers a reciprocal relationship between dendrite geometry, the ability to generate nuclear calcium transients in response to synaptic inputs, and the subsequent induction of expression of plasticity-related and dendritic structure-preserving genes. Insufficient nuclear calcium signaling in CA1 hippocampal neurons and, consequently, reduced expression of the nuclear calcium target gene VEGFD.
Title: Reciprocal Interaction of Dendrite Geometry and Nuclear Calcium-VEGFD Signaling Gates Memory Consolidation and Extinction.
Overexpression of VEGFD causes lymphatic hyperplasia in lung, kidney, and brown adipose tissue. Overexpression of VEGFD in white adipose tissue causes a de novo lymphatic network.
Title: Hyperplasia, de novo lymphangiogenesis, and lymphatic regression in mice with tissue-specific, inducible overexpression of murine VEGF-D.
Vegf-d promotes oedema in response to hyperoxia in mice and support the hypothesis that VEGF-D signalling promotes vascular leak in human hyperoxic acute lung injury (HALI).
Title: VEGF-D promotes pulmonary oedema in hyperoxic acute lung injury.
VEGF-D may be beneficial in early-stage tumors since it suppresses the pro-tumorigenic inflammation, while at later stages VEGF-D-induced tumor lymphatics provide a route for metastasis.
Title: Elevated VEGF-D Modulates Tumor Inflammation and Reduces the Growth of Carcinogen-Induced Skin Tumors.
These results suggest that lymph node lymphangiogenesis occurs before metastasis in OSCC. VEGF-A and VEGF-D play critical roles in this process.
Title: Primary Tumor-Secreted Lymphangiogenic Factors Induce Pre-Metastatic Lymphvascular Niche Formation at Sentinel Lymph Nodes in Oral Squamous Cell Carcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (36)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2) 1 citation
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Figf (e-PCR), detects polymorphism
- UniSTS:470539

Vegfc (e-PCR), detects polymorphism
- UniSTS:470546

AI325264 (e-PCR)
- UniSTS:163627

Figf (e-PCR), detects polymorphism
- UniSTS:545847

Figf (e-PCR), detects polymorphism
- UniSTS:496829

Vegfa (e-PCR), detects polymorphism
- UniSTS:528636

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chemoattractant activity	IBA Inferred from Biological aspect of Ancestor more info
enables chemoattractant activity	ISO Inferred from Sequence Orthology more info
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
NOT enables vascular endothelial growth factor receptor 2 binding	IDA Inferred from Direct Assay more info
enables vascular endothelial growth factor receptor 3 binding	IDA Inferred from Direct Assay more info	PubMed
enables vascular endothelial growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables vascular endothelial growth factor receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in dopaminergic neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within fibroblast proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in induction of positive chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in induction of positive chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info
involved_in positive regulation of endothelial cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mast cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of mast cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of vascular endothelial growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IBA Inferred from Biological aspect of Ancestor more info
involved_in sprouting angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in vascular endothelial growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within vascular endothelial growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in vascular endothelial growth factor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: vascular endothelial growth factor D

Names: c-fos induced growth factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001308489.2 → NP_001295418.1 vascular endothelial growth factor D isoform VEGF-D326 preproprotein

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR compared to variant 1. The encoded isoform (VEGF-D326) has a shorter, distinct C-terminus compared to isoform VEGF-D326.

Source sequence(s)

AL732475

UniProtKB/Swiss-Prot

P97946

Conserved Domains (1) summary

smart00141
Location:114 → 198

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
NM_001410630.1 → NP_001397559.1 vascular endothelial growth factor D isoform VEGF-D326 preproprotein

Status: VALIDATED

Source sequence(s)

AL732475
NM_001410631.1 → NP_001397560.1 vascular endothelial growth factor D isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AL732475
NM_001410632.1 → NP_001397561.1 vascular endothelial growth factor D isoform 4

Status: VALIDATED

Source sequence(s)

AL732475
NM_001410633.1 → NP_001397562.1 vascular endothelial growth factor D isoform 5

Status: VALIDATED

Source sequence(s)

AL732475
NM_010216.3 → NP_034346.1 vascular endothelial growth factor D isoform VEGF-D358 preproprotein

See identical proteins and their annotated locations for NP_034346.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (VEGF-D358).

Source sequence(s)

AL732475

Consensus CDS

CCDS30521.1

UniProtKB/Swiss-Prot

A2AIH3, P97946

Related

ENSMUSP00000033751.8, ENSMUST00000033751.8

Conserved Domains (1) summary

smart00141
Location:114 → 198

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family