U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Fgf8 fibroblast growth factor 8 [ Mus musculus (house mouse) ]

Gene ID: 14179, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Fgf8provided by MGI
Official Full Name
fibroblast growth factor 8provided by MGI
Primary source
MGI:MGI:99604
See related
Ensembl:ENSMUSG00000025219 AllianceGenome:MGI:99604
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Aigf; Fgf-8; Fgf6c; HBGF-8
Summary
Predicted to enable signaling receptor binding activity. Involved in outflow tract septum morphogenesis. Acts upstream of or within several processes, including animal organ development; blood vessel morphogenesis; and embryonic morphogenesis. Predicted to be located in external side of plasma membrane. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including alimentary system; branchial arch; embryo ectoderm; embryo mesenchyme; and sensory organ. Used to study DiGeorge syndrome and tetralogy of Fallot. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 6 with or without anosmia and prostate carcinoma in situ. Orthologous to human FGF8 (fibroblast growth factor 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 1.9), ovary adult (RPKM 1.5) and 5 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
19 C3; 19 38.75 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (45724930..45731380, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (45736491..45742941, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene deleted in primary ciliary dyskinesia Neighboring gene F-box and WD-40 domain protein 4 Neighboring gene STARR-seq mESC enhancer starr_46281 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:45758150-45758404 Neighboring gene CR4 enhancer downstream of Fgf8 Neighboring gene RIKEN cDNA 4933429K18 gene Neighboring gene CR2 enhancer downstream of Fgf8 Neighboring gene Fgf8 enhancer CR1 Neighboring gene STARR-positive B cell enhancer ABC_E11033 Neighboring gene nucleoplasmin 3 Neighboring gene O-GlcNAcase Neighboring gene STARR-positive B cell enhancer ABC_E4286

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Fgf8 regulates first pharyngeal arch segmentation through pouch-cleft interactions. Zbasnik N, et al. Front Cell Dev Biol, 2023. PMID 37287454, Free PMC Article
  2. Fibroblast growth factor 8 (FGF8) up-regulates gelatinase expression in chondrocytes through nuclear factor-κB p65. Huang H, et al. J Bone Miner Metab, 2023 Jan. PMID 36512085
  3. Fibroblast growth factor 8 regulates postnatal development of paraventricular nucleus neuroendocrine cells. Rodriguez KM, et al. Behav Brain Funct, 2015 Nov 4. PMID 26537115, Free PMC Article
  4. Fgf8-Deficient Mice Compensate for Reduced GnRH Neuronal Population and Exhibit Normal Testicular Function. Zhang W, et al. Front Endocrinol (Lausanne), 2015. PMID 26441841, Free PMC Article
  5. Fibroblast growth factor 8 deficiency compromises the functional response of the serotonergic system to stress. Brooks LR, et al. PLoS One, 2014. PMID 24992493, Free PMC Article

See all (1186) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Aberrant differentiation of second heart field mesoderm prefigures cellular defects in the outflow tract in response to loss of FGF8.
    Title: Aberrant differentiation of second heart field mesoderm prefigures cellular defects in the outflow tract in response to loss of FGF8.
  2. Combinatorial effects on gene expression at the Lbx1/Fgf8 locus resolve split-hand/foot malformation type 3.
    Title: Combinatorial effects on gene expression at the Lbx1/Fgf8 locus resolve split-hand/foot malformation type 3.
  3. Fgf8 promotes survival of nephron progenitors by regulating BAX/BAK-mediated apoptosis.
    Title: Fgf8 promotes survival of nephron progenitors by regulating BAX/BAK-mediated apoptosis.
  4. Fibroblast growth factor 8 (FGF8) up-regulates gelatinase expression in chondrocytes through nuclear factor-kappaB p65.
    Title: Fibroblast growth factor 8 (FGF8) up-regulates gelatinase expression in chondrocytes through nuclear factor-κB p65.
  5. FGF8 induces chemokinesis and regulates condensation of mouse nephron progenitor cells.
    Title: FGF8 induces chemokinesis and regulates condensation of mouse nephron progenitor cells.
  6. Position effects at the FGF8 locus are associated with femoral hypoplasia.
    Title: Position effects at the FGF8 locus are associated with femoral hypoplasia.
  7. Delta-like ligand 4-mediated Notch signaling controls proliferation of second heart field progenitor cells by regulating Fgf8 expression.
    Title: Delta-like ligand 4-mediated Notch signaling controls proliferation of second heart field progenitor cells by regulating Fgf8 expression.
  8. Nephron Progenitor Maintenance Is Controlled through Fibroblast Growth Factors and Sprouty1 Interaction.
    Title: Nephron Progenitor Maintenance Is Controlled through Fibroblast Growth Factors and Sprouty1 Interaction.
  9. Dissection of the Fgf8 regulatory landscape by in vivo CRISPR-editing reveals extensive intra- and inter-enhancer redundancy.
    Title: Dissection of the Fgf8 regulatory landscape by in vivo CRISPR-editing reveals extensive intra- and inter-enhancer redundancy.
  10. Fgf8 genetic labeling reveals the early specification of vestibular hair cell type in mouse utricle.
    Title: Fgf8 genetic labeling reveals the early specification of vestibular hair cell type in mouse utricle.
Submit: New GeneRIF Correction See all GeneRIFs (137)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC59627

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chemoattractant activity ISO
Inferred from Sequence Orthology
more info
  
enables growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables growth factor activity ISO
Inferred from Sequence Orthology
more info
  
enables type 1 fibroblast growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables type 1 fibroblast growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables type 2 fibroblast growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables type 2 fibroblast growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within aorta morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within blood vessel remodeling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in bone development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within branching involved in blood vessel morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within branching involved in salivary gland morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within branching involved in salivary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell fate commitment IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cell migration involved in mesendoderm migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of cell population proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell proliferation in forebrain IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in central nervous system neuron development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within corticotropin hormone secreting cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dopaminergic neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in dopaminergic neuron differentiation TAS
Traceable Author Statement
more info
 PubMed 
involved_in dorsal/ventral axon guidance ISO
Inferred from Sequence Orthology
more info
  
involved_in dorsal/ventral pattern formation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryonic heart tube development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryonic hindlimb morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within embryonic neurocranium morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within epithelial to mesenchymal transition involved in endocardial cushion formation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in epithelial to mesenchymal transition involved in endocardial cushion formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within forebrain dorsal/ventral pattern formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within forebrain morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in forebrain neuron development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within generation of neurons IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gonad development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart looping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within inner ear morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within larynx morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within limb morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within lung development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lung morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within male genitalia development IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within mesodermal cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within midbrain-hindbrain boundary development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of mitotic nuclear division IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in motor neuron axon guidance ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cardiac muscle tissue development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neural plate morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuroepithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of organ growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of organ growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within organ induction IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within otic vesicle formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in otic vesicle formation TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within outflow tract morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in outflow tract septum morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within pallium development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pharyngeal system development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of mitotic nuclear division IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of organ growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of organ growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of stem cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of odontogenesis of dentin-containing tooth IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within signal transduction involved in regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of stem cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within subpallium development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within telencephalon development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within thyroid gland development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within thyroid gland development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within thyroid-stimulating hormone-secreting cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
fibroblast growth factor 8
Names
androgen-induced growth factor
fibroblast growth factor 6c
heparin-binding growth factor 8

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166361.2 → NP_001159833.1  fibroblast growth factor 8 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001159833.1

    Status: VALIDATED

    Source sequence(s)
    AC149086
    Consensus CDS
    CCDS50452.1
    UniProtKB/TrEMBL
    Q80ZL6
    Related
    ENSMUSP00000026240.8, ENSMUST00000026240.14
    Conserved Domains (1) summary
    pfam00167
    Location:81 → 204
    FGF; Fibroblast growth factor

  2. NM_001166362.2 → NP_001159834.1  fibroblast growth factor 8 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001159834.1

    Status: VALIDATED

    Source sequence(s)
    AC149086
    Consensus CDS
    CCDS50451.1
    UniProtKB/TrEMBL
    G3DRA7, Q3V279
    Related
    ENSMUSP00000107559.2, ENSMUST00000111928.8
    Conserved Domains (1) summary
    pfam00167
    Location:52 → 175
    FGF; Fibroblast growth factor

  3. NM_001166363.2 → NP_001159835.1  fibroblast growth factor 8 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001159835.1

    Status: VALIDATED

    Source sequence(s)
    AC149086
    Consensus CDS
    CCDS50450.1
    UniProtKB/TrEMBL
    G3DRA7
    Related
    ENSMUSP00000107558.2, ENSMUST00000111927.8
    Conserved Domains (1) summary
    pfam00167
    Location:41 → 164
    FGF; Fibroblast growth factor

  4. NM_001379139.1 → NP_001366068.1  fibroblast growth factor 8 isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AC149086
    Conserved Domains (1) summary
    pfam00167
    Location:134 → 257
    FGF; Fibroblast growth factor

  5. NM_001379140.1 → NP_001366069.1  fibroblast growth factor 8 isoform 6 precursor

    Status: VALIDATED

    Source sequence(s)
    AC149086
    Conserved Domains (1) summary
    pfam00167
    Location:116 → 239
    FGF; Fibroblast growth factor

  6. NM_001403100.1 → NP_001390029.1  fibroblast growth factor 8 isoform 7 precursor

    Status: VALIDATED

    Source sequence(s)
    AC149086

  7. NM_010205.3 → NP_034335.1  fibroblast growth factor 8 isoform 1 precursor

    See identical proteins and their annotated locations for NP_034335.1

    Status: VALIDATED

    Source sequence(s)
    AC149086
    Consensus CDS
    CCDS29864.1
    UniProtKB/Swiss-Prot
    P37237
    Related
    ENSMUSP00000026241.6, ENSMUST00000026241.12
    Conserved Domains (1) summary
    pfam00167
    Location:105 → 228
    FGF; Fibroblast growth factor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    45724930..45731380 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526668.4 → XP_006526731.1  fibroblast growth factor 8 isoform X2

    See identical proteins and their annotated locations for XP_006526731.1

    UniProtKB/TrEMBL
    D3Z207, G3DRA7
    Related
    ENSMUSP00000107556.2, ENSMUST00000111925.2
    Conserved Domains (1) summary
    pfam00167
    Location:70 → 193
    FGF; Fibroblast growth factor
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P37237.1 GenPept UniProtKB/Swiss-Prot:P37237

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous