Fgf17 fibroblast growth factor 17 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fgf17provided by MGI
Official Full Name: fibroblast growth factor 17provided by MGI
Primary source: MGI:MGI:1202401
See related: Ensembl:ENSMUSG00000022101 AllianceGenome:MGI:1202401
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fgf6b; FGF-17
Summary: Predicted to enable growth factor activity; type 1 fibroblast growth factor receptor binding activity; and type 2 fibroblast growth factor receptor binding activity. Acts upstream of or within fibroblast growth factor receptor signaling pathway and positive regulation of cell population proliferation. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including arterial system; central nervous system; embryo ectoderm; embryo mesenchyme; and skeleton. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 20 with or without anosmia. Orthologous to human FGF17 (fibroblast growth factor 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E11.5 (RPKM 2.3), CNS E14 (RPKM 0.7) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D2; 14 36.4 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (70873643..70880064, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (70636203..70642268, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17.
Title: Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17.
The Fgf8 subfamily (Fgf8, Fgf17 and Fgf18) is required for closure of the embryonic ventral body wall.
Title: The Fgf8 subfamily (Fgf8, Fgf17 and Fgf18) is required for closure of the embryonic ventral body wall.
Cre fate mapping in Fgf17 mutant embryos revealed novel functions of this gene in rostral patterning center progenitor development. Disruption resulted in aberrant progenitor number and distribution in the rostral telencephalon.
Title: Fgf signaling controls the telencephalic distribution of Fgf-expressing progenitors generated in the rostral patterning center.
These results demonstrate that Fgf17 plays important roles in both the anatomical and functional development of the auditory midbrain
Title: Morphological and functional midbrain phenotypes in Fibroblast Growth Factor 17 mutant mice detected by Mn-enhanced MRI.
Emx2 and Fgf17 antagonistically regulate the expression of Erm, Pea3, and Er81 in the rostral cortical neuroepithelium and frontal cortex regionalization.
Title: Frontal cortex subdivision patterning is coordinately regulated by Fgf8, Fgf17, and Emx2.
Fgf17 is required for several complex social behaviors and suggest that disturbances in Fgf17 signaling may contribute to neuropsychiatric diseases that affect such behaviors.
Title: Abnormal social behaviors in mice lacking Fgf17.
The expression from early streak stage to midgestation of Fgf17 is measured. It is closely related to Fgf8 (63.7% identical at the amino acid level). Fgf17 is expressed during gastrulation but at lower levels than Fgf8.
Title: Comparison of the expression of three highly related genes, Fgf8, Fgf17 and Fgf18, in the mouse embryo.
Fgf17 functions similar to Fgf8 in patterning the overall neocortical map
Title: Patterning of frontal cortex subdivisions by Fgf17.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (3) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

Fgf17 (e-PCR), detects polymorphism
- UniSTS:507919

Fgf17 (e-PCR), detects polymorphism
- UniSTS:516628

NoName (e-PCR)
- UniSTS:492834

Fgf17 (e-PCR), detects polymorphism
- UniSTS:258263

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables type 1 fibroblast growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables type 1 fibroblast growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables type 2 fibroblast growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables type 2 fibroblast growth factor receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in fibroblast growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: fibroblast growth factor 17

Names: fibroblast growth factor 6b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360108.2 → NP_001347037.1 fibroblast growth factor 17 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC154563

Consensus CDS

CCDS88709.1

UniProtKB/TrEMBL

B7ZMS7, Q8C471

Related

ENSMUSP00000154684.2, ENSMUST00000227123.2

Conserved Domains (1) summary

pfam00167
Location:42 → 164

FGF; Fibroblast growth factor
NM_008004.6 → NP_032030.1 fibroblast growth factor 17 isoform 1 precursor

See identical proteins and their annotated locations for NP_032030.1

Status: VALIDATED

Source sequence(s)

AC154563

Consensus CDS

CCDS27260.1

UniProtKB/Swiss-Prot

O70627, P63075

UniProtKB/TrEMBL

Q0VF19, Q8C471

Related

ENSMUSP00000022697.6, ENSMUST00000022697.7

Conserved Domains (1) summary

pfam00167
Location:53 → 175

FGF; Fibroblast growth factor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

70873643..70880064 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158460.1 → XP_036014353.1 fibroblast growth factor 17 isoform X2

UniProtKB/Swiss-Prot

O70627, P63075

UniProtKB/TrEMBL

Q0VF19, Q8C471

Conserved Domains (1) summary

pfam00167
Location:53 → 175

FGF; Fibroblast growth factor
XM_036158459.1 → XP_036014352.1 fibroblast growth factor 17 isoform X2

UniProtKB/Swiss-Prot

O70627, P63075

UniProtKB/TrEMBL

Q0VF19, Q8C471

Conserved Domains (1) summary

pfam00167
Location:53 → 175

FGF; Fibroblast growth factor
XM_036158461.1 → XP_036014354.1 fibroblast growth factor 17 isoform X3

UniProtKB/TrEMBL

Q8C471

Conserved Domains (1) summary

pfam00167
Location:11 → 133

FGF; Fibroblast growth factor
XM_036158458.1 → XP_036014351.1 fibroblast growth factor 17 isoform X1

UniProtKB/TrEMBL

A0A7U3JW73

Conserved Domains (1) summary

pfam00167
Location:113 → 235

FGF; Fibroblast growth factor