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Fgf11 fibroblast growth factor 11 [ Mus musculus (house mouse) ]

Gene ID: 14166, updated on 21-Apr-2024

Summary

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Official Symbol
Fgf11provided by MGI
Official Full Name
fibroblast growth factor 11provided by MGI
Primary source
MGI:MGI:109167
See related
Ensembl:ENSMUSG00000042826 AllianceGenome:MGI:109167
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fhf3; Fgf1d; Fhf-3; Fgf-11
Summary
Predicted to enable sodium channel regulator activity. Predicted to be involved in regulation of voltage-gated sodium channel activity. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human FGF11 (fibroblast growth factor 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 10.9), CNS E18 (RPKM 7.4) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B3; 11 42.88 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69686894..69693775, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69796068..69802944, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 4 Neighboring gene STARR-seq mESC enhancer starr_29866 Neighboring gene STARR-seq mESC enhancer starr_29867 Neighboring gene cholinergic receptor nicotinic beta 1 subunit Neighboring gene STARR-positive B cell enhancer ABC_E7006 Neighboring gene RIKEN cDNA G630025P09 gene Neighboring gene transmembrane protein 102 Neighboring gene SPEM family member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Silencing of hypothalamic FGF11 prevents diet-induced obesity. Cho JH, et al. Mol Brain, 2022 Sep 5. PMID 36064426, Free PMC Article
  2. Whole embryo culture, transcriptomics and RNA interference identify TBX1 and FGF11 as novel regulators of limb development in the mouse. Tejedor G, et al. Sci Rep, 2020 Feb 27. PMID 32107392, Free PMC Article
  3. FGF11 influences 3T3-L1 preadipocyte differentiation by modulating the expression of PPARγ regulators. Lee KW, et al. FEBS Open Bio, 2019 Apr. PMID 30984550, Free PMC Article
  4. T2DM inhibition of endothelial miR-342-3p facilitates angiogenic dysfunction via repression of FGF11 signaling. Cheng S, et al. Biochem Biophys Res Commun, 2018 Sep 3. PMID 29852165
  5. FGF ligand family mRNA expression profile for mouse preimplantation embryos, early gestation human placenta, and mouse trophoblast stem cells. Zhong W, et al. Mol Reprod Dev, 2006 May. PMID 16470835

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Silencing of hypothalamic FGF11 prevents diet-induced obesity.
    Title: Silencing of hypothalamic FGF11 prevents diet-induced obesity.
  2. Whole embryo culture, transcriptomics and RNA interference identify TBX1 and FGF11 as novel regulators of limb development in the mouse.
    Title: Whole embryo culture, transcriptomics and RNA interference identify TBX1 and FGF11 as novel regulators of limb development in the mouse.
  3. FGF11 indirectly controls the expression of PPARgamma through modifying the expression of multiple PPARgamma regulators, thereby mediating adipogenesis.
    Title: FGF11 influences 3T3-L1 preadipocyte differentiation by modulating the expression of PPARγ regulators.
  4. endothelial miR-342-3p expression was significantly compromised in T2DM organisms and this inhibition powerfully blocked vasculogenesis in vivo by repressing endothelial proliferation and migration. From a mechanistic standpoint, miR-342-3p promoted the transactivation of fibroblast growth factor 11 (FGF11) by directly targeting its 3' untranslated regions (3'UTRs).
    Title: T2DM inhibition of endothelial miR-342-3p facilitates angiogenic dysfunction via repression of FGF11 signaling.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
  
enables sodium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of voltage-gated sodium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
fibroblast growth factor 11
Names
fibroblast growth factor 1d
fibroblast growth factor homologous factor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291104.2 → NP_001278033.1  fibroblast growth factor 11 isoform 2

    See identical proteins and their annotated locations for NP_001278033.1

    Status: VALIDATED

    Source sequence(s)
    AL603707, U66203
    Consensus CDS
    CCDS70218.1
    UniProtKB/TrEMBL
    Q6NXW2
    Related
    ENSMUSP00000011285.5, ENSMUST00000011285.11
    Conserved Domains (1) summary
    cl00060
    Location:69 → 171
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...

  2. NM_001362623.1 → NP_001349552.1  fibroblast growth factor 11 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL603707
    Consensus CDS
    CCDS24911.1
    UniProtKB/Swiss-Prot
    P70378, Q5F291
    UniProtKB/TrEMBL
    A0A7U3L4H2
    Related
    ENSMUSP00000099645.2, ENSMUST00000102585.2
    Conserved Domains (1) summary
    smart00442
    Location:69 → 199
    FGF; Acidic and basic fibroblast growth factor family

  3. NM_001362624.1 → NP_001349553.1  fibroblast growth factor 11 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL603707
    Conserved Domains (1) summary
    smart00442
    Location:69 → 199
    FGF; Acidic and basic fibroblast growth factor family

  4. NM_010198.3 → NP_034328.1  fibroblast growth factor 11 isoform 1

    See identical proteins and their annotated locations for NP_034328.1

    Status: VALIDATED

    Source sequence(s)
    AL603707, U66203
    Consensus CDS
    CCDS24911.1
    UniProtKB/Swiss-Prot
    P70378, Q5F291
    UniProtKB/TrEMBL
    A0A7U3L4H2
    Conserved Domains (1) summary
    smart00442
    Location:69 → 199
    FGF; Acidic and basic fibroblast growth factor family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    69686894..69693775 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532188.5 → XP_006532251.1  fibroblast growth factor 11 isoform X2

    See identical proteins and their annotated locations for XP_006532251.1

    UniProtKB/TrEMBL
    Q6NXW2
    Conserved Domains (1) summary
    cl00060
    Location:69 → 171
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...

  2. XM_011248722.3 → XP_011247024.1  fibroblast growth factor 11 isoform X1

    See identical proteins and their annotated locations for XP_011247024.1

    Conserved Domains (1) summary
    smart00442
    Location:69 → 207
    FGF; Acidic and basic fibroblast growth factor family

  3. XM_011248721.3 → XP_011247023.1  fibroblast growth factor 11 isoform X1

    See identical proteins and their annotated locations for XP_011247023.1

    Conserved Domains (1) summary
    smart00442
    Location:69 → 207
    FGF; Acidic and basic fibroblast growth factor family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70378.1 GenPept UniProtKB/Swiss-Prot:P70378

Gene LinkOut

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