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Siah1 siah E3 ubiquitin protein ligase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 140941, updated on 3-Apr-2024

Summary

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Official Symbol
Siah1provided by RGD
Official Full Name
siah E3 ubiquitin protein ligase 1provided by RGD
Primary source
RGD:620449
See related
Ensembl:ENSRNOG00000015143 AllianceGenome:RGD:620449
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
SIAH; Siah1a
Summary
Enables protein C-terminus binding activity and ubiquitin-protein transferase activity. Involved in neuron apoptotic process; protein destabilization; and ubiquitin-dependent protein catabolic process. Located in several cellular components, including cytosol; early endosome; and nucleus. Orthologous to human SIAH1 (siah E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 51.2), Adrenal (RPKM 48.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
19p11
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (36552165..36575773)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (20378908..20402512)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (21372163..21395773)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene Nedd4 binding protein 1 Neighboring gene uncharacterized LOC102547741 Neighboring gene lon peptidase 2, peroxisomal Neighboring gene U6 spliceosomal RNA Neighboring gene ATP binding cassette subfamily C member 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. E3 ubiquitin ligase siah‑1 nuclear accumulation is critical for homocysteine‑induced impairment of C6 astroglioma cells. Tian X, et al. Mol Med Rep, 2019 Sep. PMID 31322210, Free PMC Article
  2. Calcyclin-binding protein/Siah-1-interacting protein as a regulator of transcriptional responses in brain cells. Kilanczyk E, et al. J Neurosci Res, 2015 Jan. PMID 25163685, Free PMC Article
  3. A role for Seven in Absentia Homolog (Siah1a) in metabotropic glutamate receptor signaling. Kammermeier PJ, et al. BMC Neurosci, 2001. PMID 11686852, Free PMC Article
  4. Inhibiting a spinal cord signaling pathway protects against ischemia injury in rats. Huo J, et al. J Thorac Cardiovasc Surg, 2019 Feb. PMID 30195603
  5. An upregulation of SIAH1 after spinal cord injury in adult rats. Wang D, et al. J Mol Neurosci, 2011 Oct. PMID 21336655

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These findings suggest that siah1 is involved in homocysteineinduced cell damage by promoting the nuclear translocation of glyceraldehyde 3phosphate dehydrogenase .
    Title: E3 ubiquitin ligase siah‑1 nuclear accumulation is critical for homocysteine‑induced impairment of C6 astroglioma cells.
  2. Study reveals GAPDH/Siah1 as a novel signaling pathway in apoptosis and function recovery after traumatic spinal cord injury. This signaling pathway in the spinal cord can be blocked by sivelestat sodium.
    Title: GAPDH/Siah1 cascade is involved in traumatic spinal cord injury and could be attenuated by sivelestat sodium.
  3. The results of this study indicated that CacyBP/SIP is a novel regulator of CRE- and NFAT-driven transcription.
    Title: Calcyclin-binding protein/Siah-1-interacting protein as a regulator of transcriptional responses in brain cells.
  4. Data suggest SIAH1 involvement in the injury response of the adult spinal cord of the rats.
    Title: An upregulation of SIAH1 after spinal cord injury in adult rats.
  5. siah-1 Protein is necessary for high glucose-induced glyceraldehyde-3-phosphate dehydrogenase nuclear accumulation and cell death in Muller
    Title: siah-1 Protein is necessary for high glucose-induced glyceraldehyde-3-phosphate dehydrogenase nuclear accumulation and cell death in Muller cells.
  6. synphilin-1A has a novel role as a regulator of SIAH activity, modulating alpha-synuclein, and formation of Lewy body-like inclusions
    Title: Synphilin-1A inhibits seven in absentia homolog (SIAH) and modulates alpha-synuclein monoubiquitylation and inclusion formation.
  7. These results suggest that Siah-1 might play a role as a regulator of FIH abundance under normoxic conditions.
    Title: Abundance of aspargynyl-hydroxylase FIH is regulated by Siah-1 under normoxic conditions.
  8. Binds group I metabotropic glutamate receptors and calmodulin; calmodulin binding may play a role in the regulation of group I mGluR function
    Title: A role for Seven in Absentia Homolog (Siah1a) in metabotropic glutamate receptor signaling.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables disordered domain specific binding IEA
Inferred from Electronic Annotation
more info
  
enables disordered domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in male meiosis I IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within male meiosis I ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in post-embryonic development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within post-embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein destabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
  
part_of SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of beta-catenin destruction complex IEA
Inferred from Electronic Annotation
more info
  
part_of beta-catenin destruction complex ISO
Inferred from Sequence Orthology
more info
  
part_of beta-catenin destruction complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase SIAH1
Names
RING-type E3 ubiquitin transferase SIAH1
seven in absentia 1A
seven in absentia homolog 1
siah-1
siah-1a
NP_543181.2
XP_008770567.1
XP_038953365.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080905.2 → NP_543181.2  E3 ubiquitin-protein ligase SIAH1

    See identical proteins and their annotated locations for NP_543181.2

    Status: VALIDATED

    Source sequence(s)
    AF389476, BQ780107, DV213782
    UniProtKB/Swiss-Prot
    Q920M9
    UniProtKB/TrEMBL
    A0A8I6APD1, A9UK92
    Related
    ENSRNOP00000092688.1, ENSRNOT00000112896.1
    Conserved Domains (2) summary
    cd16751
    Location:39 → 78
    RING-HC_SIAH1; RING finger, HC subclass, found in seven in absentia homolog 1 (SIAH1) and similar proteins
    pfam03145
    Location:82 → 278
    Sina; Seven in absentia protein family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    36552165..36575773
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008772345.4 → XP_008770567.1  E3 ubiquitin-protein ligase SIAH1 isoform X1

    See identical proteins and their annotated locations for XP_008770567.1

    UniProtKB/Swiss-Prot
    Q920M9
    UniProtKB/TrEMBL
    A0A8I6APD1, A9UK92
    Related
    ENSRNOP00000089183.1
    Conserved Domains (2) summary
    cd16751
    Location:39 → 78
    RING-HC_SIAH1; RING finger, HC subclass, found in seven in absentia homolog 1 (SIAH1) and similar proteins
    pfam03145
    Location:82 → 278
    Sina; Seven in absentia protein family

  2. XM_039097437.2 → XP_038953365.1  E3 ubiquitin-protein ligase SIAH1 isoform X1

    UniProtKB/Swiss-Prot
    Q920M9
    UniProtKB/TrEMBL
    A0A8I6APD1, A9UK92
    Related
    ENSRNOP00000092754.1
    Conserved Domains (2) summary
    cd16751
    Location:39 → 78
    RING-HC_SIAH1; RING finger, HC subclass, found in seven in absentia homolog 1 (SIAH1) and similar proteins
    pfam03145
    Location:82 → 278
    Sina; Seven in absentia protein family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q920M9.2 GenPept UniProtKB/Swiss-Prot:Q920M9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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