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Elp1 elongator acetyltransferase complex subunit 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 140934, updated on 13-Apr-2024

Summary

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Symbol
Elp1provided by RGD
Full Name
elongator acetyltransferase complex subunit 1provided by RGD
Primary source
RGD:620072
See related
Ensembl:ENSRNOG00000016725 AllianceGenome:RGD:620072
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ikbkap
Summary
Enables ATP binding activity and protein kinase activity. Involved in I-kappaB phosphorylation. Predicted to be located in cytoplasm. Predicted to be part of elongator holoenzyme complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Riley-Day syndrome; asthma; medulloblastoma; and scoliosis. Orthologous to human ELP1 (elongator acetyltransferase complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 190.0), Adrenal (RPKM 185.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Elp1 in Genome Data Viewer
Location:
5q24
Exon count:
38
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (76248545..76300985, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (71453338..71505833, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (73503406..73552798, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene actin-like 7b Neighboring gene actin-like 7a Neighboring gene actin binding transcription modulator Neighboring gene catenin alpha-like 1 Neighboring gene transmembrane protein 245

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Up-regulation of bradykinin receptors in rat bronchi via I kappa B kinase-mediated inflammatory signaling pathway. Lei Y, et al. Eur J Pharmacol, 2010 May 25. PMID 20184874
  2. Norepinephrine increases I kappa B alpha expression in astrocytes. Gavrilyuk V, et al. J Biol Chem, 2002 Aug 16. PMID 12050158
  3. Orthopaedic manifestations of familial dysautonomia. A review of one hundred and thirty-six patients. Bar-On E, et al. J Bone Joint Surg Am, 2000 Nov. PMID 11097445
  4. The role of the IKAP gene polymorphisms in atopic diseases in the middle European population. Schüller M, et al. J Hum Genet, 2003. PMID 12774215
  5. Measurement of IKK activity in primary rat T cells: rapid activation and inactivation. Kupfer R, et al. J Immunol Methods, 2002 Aug 1. PMID 12133632

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA wobble uridine modification ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of elongator holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of elongator holoenzyme complex IEA
Inferred from Electronic Annotation
more info
  
part_of elongator holoenzyme complex ISO
Inferred from Sequence Orthology
more info
  
part_of elongator holoenzyme complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
elongator complex protein 1
Names
IKK complex-associated protein
elongator complex protein 1-like
ikappaB kinase complex-associated protein
inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080899.2 → NP_543175.2  elongator complex protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    Q8VHU4
    UniProtKB/TrEMBL
    A6KDR5, F1LP76
    Related
    ENSRNOP00000022836.5, ENSRNOT00000022836.6
    Conserved Domains (3) summary
    COG0457
    Location:874 → 1099
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00039
    Location:112 → 147
    7WD40; WD40 repeat [structural motif]
    pfam04762
    Location:1 → 953
    IKI3; IKI3 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    76248545..76300985 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109191.2 → XP_038965119.1  elongator complex protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8VHU4
    Conserved Domains (3) summary
    COG0457
    Location:874 → 1099
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00039
    Location:112 → 147
    7WD40; WD40 repeat [structural motif]
    pfam04762
    Location:1 → 953
    IKI3; IKI3 family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VHU4.1 GenPept UniProtKB/Swiss-Prot:Q8VHU4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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