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Il2rg interleukin 2 receptor subunit gamma [ Rattus norvegicus (Norway rat) ]

Gene ID: 140924, updated on 3-Apr-2024

Summary

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Official Symbol
Il2rgprovided by RGD
Official Full Name
interleukin 2 receptor subunit gammaprovided by RGD
Primary source
RGD:621466
See related
Ensembl:ENSRNOG00000003954 AllianceGenome:RGD:621466
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cd132; Ab2-183
Summary
Predicted to enable interleukin-15 receptor activity and interleukin-2 binding activity. Predicted to be involved in interleukin-15-mediated signaling pathway and positive regulation of phagocytosis. Predicted to act upstream of or within positive regulation of gene expression and positive regulation of lymphocyte differentiation. Predicted to be located in cell surface. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Used to study X-linked severe combined immunodeficiency and combined T cell and B cell immunodeficiency. Human ortholog(s) of this gene implicated in X-linked severe combined immunodeficiency; combined T cell and B cell immunodeficiency; and severe combined immunodeficiency. Orthologous to human IL2RG (interleukin 2 receptor subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 646.5), Spleen (RPKM 370.5) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
Xq22
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (70435340..70439052, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (66395330..66399026, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (71165378..71169078, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene forkhead box O4 Neighboring gene similar to human chromosome X open reading frame 65 Neighboring gene mediator complex subunit 12 Neighboring gene neuroligin 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Generation of knockout rats with X-linked severe combined immunodeficiency (X-SCID) using zinc-finger nucleases. Mashimo T, et al. PLoS One, 2010 Jan 25. PMID 20111598, Free PMC Article
  2. Generation of Immunodeficient Rats With Rag1 and Il2rg Gene Deletions and Human Tissue Grafting Models. Ménoret S, et al. Transplantation, 2018 Aug. PMID 29688994
  3. Screening for mutations causing X-linked severe combined immunodeficiency in the IL-2R gamma chain gene by single-strand conformation polymorphism analysis. Clark PA, et al. Hum Genet, 1995 Oct. PMID 7557965
  4. Structural basis for binding multiple ligands by the common cytokine receptor gamma-chain. Olosz F, et al. J Biol Chem, 2002 Apr 5. PMID 11815609
  5. Role of Bcl-2 in alpha beta T cell development in mice deficient in the common cytokine receptor gamma-chain: the requirement for Bcl-2 differs depending on the TCR/MHC affinity. Nakajima H, et al. J Immunol, 1999 Jan 15. PMID 9916699

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural basis for binding multiple ligands by the common cytokine receptor gamma-chain
    Title: Structural basis for binding multiple ligands by the common cytokine receptor gamma-chain.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables coreceptor activity ISO
Inferred from Sequence Orthology
more info
  
enables interleukin-15 receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables interleukin-2 binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of B cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of T cell differentiation in thymus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in interleukin-15-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in interleukin-2-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in interleukin-9-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of lymphocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of mature B cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of B cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of T cell differentiation in thymus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cytokine receptor common subunit gamma
Names
interleukin 2 receptor, gamma (severe combined immunodeficiency)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080889.1 → NP_543165.1  cytokine receptor common subunit gamma precursor

    See identical proteins and their annotated locations for NP_543165.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079343
    UniProtKB/TrEMBL
    A6IQA7, F7ER36, Q68FU6
    Related
    ENSRNOP00000005343.4, ENSRNOT00000005343.8
    Conserved Domains (2) summary
    cd00063
    Location:154 → 246
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:59 → 116
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    70435340..70439052 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063279764.1 → XP_063135834.1  cytokine receptor common subunit gamma isoform X1

    UniProtKB/TrEMBL
    A6IQA8

  2. XM_017601899.3 → XP_017457388.1  cytokine receptor common subunit gamma isoform X2

    UniProtKB/TrEMBL
    D3JTH6
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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