Fadd Fas associated via death domain [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Faddprovided by MGI
Official Full Name: Fas associated via death domainprovided by MGI
Primary source: MGI:MGI:109324
See related: Ensembl:ENSMUSG00000031077 AllianceGenome:MGI:109324
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mort1/FADD
Summary: Predicted to enable several functions, including caspase binding activity; death effector domain binding activity; and tumor necrosis factor receptor superfamily binding activity. Involved in several processes, including hematopoietic or lymphoid organ development; negative regulation of activation-induced cell death of T cells; and positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation. Acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand; motor neuron apoptotic process; and regulation of programmed cell death. Predicted to be located in several cellular components, including cell body; cytosol; and membrane raft. Predicted to be part of CD95 death-inducing signaling complex and ripoptosome. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in leukemia. Orthologous to human FADD (Fas associated via death domain). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 10.0), large intestine adult (RPKM 9.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F5; 7 88.85 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (144132060..144136178, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (144578323..144582441, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RIPK1 plays a crucial role in maintaining regulatory T-Cell homeostasis by inhibiting both RIPK3- and FADD-mediated cell death.
Title: RIPK1 plays a crucial role in maintaining regulatory T-Cell homeostasis by inhibiting both RIPK3- and FADD-mediated cell death.
FADD- and RIPK3-Mediated Cell Death Ensures Clearance of Ly6C[high] Wound Macrophages from Damaged Tissue.
Title: FADD- and RIPK3-Mediated Cell Death Ensures Clearance of Ly6C(high) Wound Macrophages from Damaged Tissue.
FADD phosphorylation contributes to development of renal fibrosis by accelerating epithelial-mesenchymal transition.
Title: FADD phosphorylation contributes to development of renal fibrosis by accelerating epithelial-mesenchymal transition.
Caspase-8 and FADD prevent spontaneous ZBP1 expression and necroptosis.
Title: Caspase-8 and FADD prevent spontaneous ZBP1 expression and necroptosis.
The dephosphorylation of FADD at S191 induces an excessive expansion of TCRalphabeta(+) IELs in the intestinal mucosa.
Title: The dephosphorylation of FADD at S191 induces an excessive expansion of TCRαβ(+) IELs in the intestinal mucosa.
Effects of Galphai2 and Galphaz protein knockdown on alpha2A-adrenergic and cannabinoid CB1 receptor regulation of MEK-ERK and FADD pathways in mouse cerebral cortex.
Title: Effects of Gαi(2) and Gαz protein knockdown on alpha(2A)-adrenergic and cannabinoid CB(1) receptor regulation of MEK-ERK and FADD pathways in mouse cerebral cortex.
Viral dosing of influenza A infection reveals involvement of RIPK3 and FADD, but not MLKL.
Title: Viral dosing of influenza A infection reveals involvement of RIPK3 and FADD, but not MLKL.
OTULIN Prevents Liver Inflammation and Hepatocellular Carcinoma by Inhibiting FADD- and RIPK1 Kinase-Mediated Hepatocyte Apoptosis.
Title: OTULIN Prevents Liver Inflammation and Hepatocellular Carcinoma by Inhibiting FADD- and RIPK1 Kinase-Mediated Hepatocyte Apoptosis.
Diabetes induces IL-17A-Act1-FADD-dependent retinal endothelial cell death and capillary degeneration.
Title: Diabetes induces IL-17A-Act1-FADD-dependent retinal endothelial cell death and capillary degeneration.
The promotion of PSCs activation in knocking down SPOP with siSPOP-1 were counteracted by knocking down FADD.
Title: SPOP inhibits mice pancreatic stellate cell activation by promoting FADD degradation in cerulein-induced chronic pancreatitis.

Submit: New GeneRIF Correction See all GeneRIFs (82)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (12) 1 citation
Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

U50406 (e-PCR)
- UniSTS:163432

PMC305633P1 (e-PCR)
- UniSTS:272553

Fadd (e-PCR), detects polymorphism
- UniSTS:143064

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables caspase binding	IBA Inferred from Biological aspect of Ancestor more info
enables caspase binding	ISO Inferred from Sequence Orthology more info
enables death effector domain binding	ISO Inferred from Sequence Orthology more info
enables death receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables death receptor binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables receptor serine/threonine kinase binding	ISO Inferred from Sequence Orthology more info
enables signaling adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables tumor necrosis factor receptor binding	ISO Inferred from Sequence Orthology more info
enables tumor necrosis factor receptor superfamily binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T cell differentiation	TAS Traceable Author Statement more info	PubMed
involved_in T cell differentiation in thymus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in TRAIL-activated apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in activation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle tissue development	TAS Traceable Author Statement more info	PubMed
involved_in death-inducing signaling complex assembly	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in extrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within extrinsic apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info
involved_in extrinsic apoptotic signaling pathway via death domain receptors	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	TAS Traceable Author Statement more info	PubMed
involved_in lymph node development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within motor neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in necroptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of activation-induced cell death of T cells	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of necroptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of T cell mediated cytotoxicity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of activated T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of adaptive immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of execution phase of apoptosis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of execution phase of apoptosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteolysis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of necroptotic process	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in spleen development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in thymus development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of CD95 death-inducing signaling complex	IBA Inferred from Biological aspect of Ancestor more info
part_of CD95 death-inducing signaling complex	ISO Inferred from Sequence Orthology more info
located_in cell body	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of death-inducing signaling complex	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of ripoptosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: FAS-associated death domain protein

Names: FAS-associating death domain-containing protein; Fas (TNFRSF6)-associated via death domain; Fas-associating protein with death domain; mediator of receptor induced toxicity; protein FADD

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010175.6 → NP_034305.1 FAS-associated death domain protein

See identical proteins and their annotated locations for NP_034305.1

Status: VALIDATED

Source sequence(s)

AC153792

Consensus CDS

CCDS22050.1

UniProtKB/Swiss-Prot

Q3TC37, Q61082, Q61160

UniProtKB/TrEMBL

Q8CD57

Related

ENSMUSP00000033394.8, ENSMUST00000033394.8

Conserved Domains (2) summary

cd08306
Location:97 → 181

Death_FADD; Fas-associated Death Domain protein-protein interaction domain

cd08336
Location:2 → 83

DED_FADD; Death Effector Domain found in Fas-Associated via Death Domain