cebpb CCAAT enhancer binding protein beta [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cebpbprovided by ZNC
Official Full Name: CCAAT enhancer binding protein betaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-020111-3
See related: Ensembl:ENSDARG00000042725 AllianceGenome:ZFIN:ZDB-GENE-020111-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb380; c/ebpb; fe11e05; wu:fe11e05
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within regulation of DNA methylation; response to bacterium; and response to yeast. Predicted to be located in nucleus. Is expressed in several structures, including EVL; digestive system; macrophage; periderm; and yolk syncytial layer. Orthologous to human CEBPB (CCAAT enhancer binding protein beta). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 8

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (28448265..28449782, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (28414257..28415774, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cebp1 and Cebpbeta transcriptional axis controls eosinophilopoiesis in zebrafish.
Title: Cebp1 and Cebpβ transcriptional axis controls eosinophilopoiesis in zebrafish.
Nr1d1/Rev-erbalpha has a direct role in circadian clock regulation of autophagy, which also involves Cebpb/(C/ebpbeta) indirectly in zebrafish
Title: The circadian clock regulates autophagy directly through the nuclear hormone receptor Nr1d1/Rev-erbα and indirectly via Cebpb/(C/ebpβ) in zebrafish.
We found that quercetin reduces the promoter activity of apoB, driven by the enforced expression of C/EBPb.
Title: Quercetin represses apolipoprotein B expression by inhibiting the transcriptional activity of C/EBPβ.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to bacterium	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to yeast	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: CCAAT/enhancer-binding protein beta

Names: CCAAT/enhancer binding protein (C/EBP), beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131884.2 → NP_571959.2 CCAAT/enhancer-binding protein beta

See identical proteins and their annotated locations for NP_571959.2

Status: PROVISIONAL

Source sequence(s)

BC049401

UniProtKB/TrEMBL

Q7ZU07

Related

ENSDARP00000062701.3, ENSDART00000062702.4

Conserved Domains (1) summary

cd14712
Location:207 → 277

bZIP_CEBPB; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein beta (CEBPB): a DNA-binding and dimerization domain