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Myh7 myosin, heavy polypeptide 7, cardiac muscle, beta [ Mus musculus (house mouse) ]

Gene ID: 140781, updated on 21-Apr-2024

Summary

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Official Symbol
Myh7provided by MGI
Official Full Name
myosin, heavy polypeptide 7, cardiac muscle, betaprovided by MGI
Primary source
MGI:MGI:2155600
See related
Ensembl:ENSMUSG00000053093 AllianceGenome:MGI:2155600
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B-MHC; Myhcb; MyHC-I; Myhc-b; betaMHC; beta-MHC; myHC-beta; myHC-slow; MYH-beta/slow
Summary
Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and identical protein binding activity. Acts upstream of or within cardiac muscle hypertrophy in response to stress and transition between fast and slow fiber. Located in Z disc and stress fiber. Part of myosin complex. Is expressed in several structures, including diaphragm; eye; heart; musculature; and somite. Human ortholog(s) of this gene implicated in cardiomyopathy (multiple); congenital heart disease (multiple); distal myopathy 1; and hyaline body myopathy (multiple). Orthologous to human MYH7 (myosin heavy chain 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward heart adult (RPKM 264.5) See more
Orthologs
human all
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Genomic context

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Location:
14 C3; 14 28.01 cM
Exon count:
41
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55208141..55232083, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (54970684..54994626, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene myosin, heavy polypeptide 6, cardiac muscle, alpha Neighboring gene microRNA 208a Neighboring gene predicted gene, 52092 Neighboring gene myosin heavy chain associated RNA transcript Neighboring gene microRNA 208b Neighboring gene predicted gene, 31251 Neighboring gene STARR-seq mESC enhancer starr_36751 Neighboring gene VISTA enhancer mm771 Neighboring gene VISTA enhancer mm1288 Neighboring gene STARR-positive B cell enhancer ABC_E7316 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:55633922-55634031 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:55634351-55634460 Neighboring gene neuroguidin, EIF4E binding protein Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model. Xia Y, et al. J Vis Exp, 2022 Aug 8. PMID 35993750
  2. Difference in potential DNA methylation impact on gene expression between fast- and slow-type myofibers. Oe M, et al. Physiol Genomics, 2021 Feb 1. PMID 33459151
  3. High-throughput single-molecule RNA imaging analysis reveals heterogeneous responses of cardiomyocytes to hemodynamic overload. Satoh M, et al. J Mol Cell Cardiol, 2019 Mar. PMID 30611794
  4. Sex dimorphisms of crossbridge cycling kinetics in transgenic hypertrophic cardiomyopathy mice. Birch CL, et al. Am J Physiol Heart Circ Physiol, 2016 Jul 1. PMID 27199124, Free PMC Article
  5. Activation of Foxo1 by insulin resistance promotes cardiac dysfunction and β-myosin heavy chain gene expression. Qi Y, et al. Circ Heart Fail, 2015 Jan. PMID 25477432, Free PMC Article

See all (258) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model.
    Title: Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model.
  2. Endogenous slow and fast myosin dynamics in myofibers isolated from mice expressing GFP-Myh7 and Kusabira Orange-Myh1.
    Title: Endogenous slow and fast myosin dynamics in myofibers isolated from mice expressing GFP-Myh7 and Kusabira Orange-Myh1.
  3. Multiscale analysis of single and double maternal-zygotic Myh9 and Myh10 mutants during mouse preimplantation development.
    Title: Multiscale analysis of single and double maternal-zygotic Myh9 and Myh10 mutants during mouse preimplantation development.
  4. We developed a new image-analysis pipeline to allow automated and unbiased quantification of gene expression at the single-cell level and determined the spatial and temporal regulation of heterogenous Myh7 expression in cardiomyocytes after pressure overload.
    Title: High-throughput single-molecule RNA imaging analysis reveals heterogeneous responses of cardiomyocytes to hemodynamic overload.
  5. These data demonstrate functional cooperation between Sox6 and Nfix in regulating MyHC-I expression during prenatal muscle development.[MyHC-1]
    Title: Nfix Induces a Switch in Sox6 Transcriptional Activity to Regulate MyHC-I Expression in Fetal Muscle.
  6. Male/female Myh7 mutant mice display sex dimorphic crossbridge kinetics accompanied by sex- and hypertrophic cardiomyopathy-dependent cardiac remodeling at the morphometric, histological, and cellular level.
    Title: Sex dimorphisms of crossbridge cycling kinetics in transgenic hypertrophic cardiomyopathy mice.
  7. The promoter regions of the SERCA-2A and beta-MHC genes, Atp2a2 and Myh7, respectively in murine hearts after one or eight weeks of pressure overload induced by transverse aortic constriction, were evaluated.
    Title: Epigenetic switch at atp2a2 and myh7 gene promoters in pressure overload-induced heart failure.
  8. Foxo1 has important roles in promoting diabetic cardiomyopathy and controls beta-MHC expression in the development of cardiac dysfunction.
    Title: Activation of Foxo1 by insulin resistance promotes cardiac dysfunction and β-myosin heavy chain gene expression.
  9. Transgenic mouse alpha- and beta-cardiac myosins containing the R403Q mutation show isoform-dependent transient kinetic differences.
    Title: Transgenic mouse α- and β-cardiac myosins containing the R403Q mutation show isoform-dependent transient kinetic differences.
  10. Cooperative/allosteric effects on actomyosin crossbridge recruitment dynamics are increased by beta-MHC.
    Title: Length-dependent effects on cardiac contractile dynamics are different in cardiac muscle containing α- or β-myosin heavy chain.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microfilament motor activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ATP metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in adult heart development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adult heart development ISO
Inferred from Sequence Orthology
more info
  
involved_in cardiac muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in muscle contraction ISO
Inferred from Sequence Orthology
more info
  
involved_in muscle filament sliding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in muscle filament sliding ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of heart rate ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of slow-twitch skeletal muscle fiber contraction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of the force of heart contraction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of the force of skeletal muscle contraction ISO
Inferred from Sequence Orthology
more info
  
involved_in sarcomere organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in skeletal muscle contraction ISO
Inferred from Sequence Orthology
more info
  
involved_in striated muscle contraction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within transition between fast and slow fiber IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ventricular cardiac muscle tissue morphogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Z disc IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of muscle myosin complex ISO
Inferred from Sequence Orthology
more info
  
located_in myofibril IDA
Inferred from Direct Assay
more info
 PubMed 
located_in myofibril ISO
Inferred from Sequence Orthology
more info
  
part_of myosin II complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of myosin complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in myosin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in myosin filament ISO
Inferred from Sequence Orthology
more info
  
located_in sarcomere ISO
Inferred from Sequence Orthology
more info
  
located_in stress fiber IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
myosin-7
Names
myosin heavy chain 7
myosin heavy chain, cardiac muscle, fetal

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361607.1 → NP_001348536.1  myosin-7

    Status: VALIDATED

    Source sequence(s)
    CT025533
    Consensus CDS
    CCDS27106.1
    UniProtKB/Swiss-Prot
    Q3TGM2, Q3TZN2, Q91Z83
    UniProtKB/TrEMBL
    B2RXX9, B2RY26
    Related
    ENSMUSP00000126840.2, ENSMUST00000168485.8
    Conserved Domains (3) summary
    COG5022
    Location:37 → 1432
    COG5022; Myosin heavy chain [General function prediction only]
    TIGR02168
    Location:1173 → 1930
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01377
    Location:99 → 766
    MYSc_class_II; class II myosins, motor domain

  2. NM_001425737.1 → NP_001412666.1  myosin-7

    Status: VALIDATED

    Source sequence(s)
    CT025533
    UniProtKB/Swiss-Prot
    Q3TGM2, Q3TZN2, Q91Z83
    UniProtKB/TrEMBL
    B2RXX9

  3. NM_080728.3 → NP_542766.1  myosin-7

    See identical proteins and their annotated locations for NP_542766.1

    Status: VALIDATED

    Source sequence(s)
    CT025533
    Consensus CDS
    CCDS27106.1
    UniProtKB/Swiss-Prot
    Q3TGM2, Q3TZN2, Q91Z83
    UniProtKB/TrEMBL
    B2RXX9, B2RY26
    Related
    ENSMUSP00000099867.4, ENSMUST00000102803.11
    Conserved Domains (3) summary
    COG5022
    Location:37 → 1432
    COG5022; Myosin heavy chain [General function prediction only]
    TIGR02168
    Location:1173 → 1930
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01377
    Location:99 → 766
    MYSc_class_II; class II myosins, motor domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    55208141..55232083 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158456.1 → XP_036014349.1  myosin-7 isoform X1

    UniProtKB/Swiss-Prot
    Q3TGM2, Q3TZN2, Q91Z83
    UniProtKB/TrEMBL
    B2RXX9, B2RY26
    Conserved Domains (3) summary
    COG5022
    Location:37 → 1432
    COG5022; Myosin heavy chain [General function prediction only]
    TIGR02168
    Location:1173 → 1930
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01377
    Location:99 → 766
    MYSc_class_II; class II myosins, motor domain

  2. XM_017315841.3 → XP_017171330.1  myosin-7 isoform X1

    UniProtKB/Swiss-Prot
    Q3TGM2, Q3TZN2, Q91Z83
    UniProtKB/TrEMBL
    B2RXX9, B2RY26
    Conserved Domains (3) summary
    COG5022
    Location:37 → 1432
    COG5022; Myosin heavy chain [General function prediction only]
    TIGR02168
    Location:1173 → 1930
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01377
    Location:99 → 766
    MYSc_class_II; class II myosins, motor domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91Z83.1 GenPept UniProtKB/Swiss-Prot:Q91Z83

Gene LinkOut

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