tfap2a transcription factor AP-2 alpha [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tfap2aprovided by ZNC
Official Full Name: transcription factor AP-2 alphaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-011212-6
See related: Ensembl:ENSDARG00000059279 AllianceGenome:ZFIN:ZDB-GENE-011212-6
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ap2; ap2a; cb93; fb83f04; fc31a07; wu:fb83f04; wu:fc31a07
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within with a positive effect on melanocyte differentiation. Acts upstream of or within several processes, including animal organ development; iridophore differentiation; and nervous system development. Located in nucleus. Is expressed in several structures, including ectoderm; nervous system; neural crest; neural tube; and pronephros. Human ortholog(s) of this gene implicated in branchiooculofacial syndrome. Orthologous to human TFAP2A (transcription factor AP-2 alpha). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (8721676..8732517, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (8581298..8592139, complement)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TFAP2 paralogs regulate midfacial development in part through a conserved ALX genetic pathway.
Title: TFAP2 paralogs regulate midfacial development in part through a conserved ALX genetic pathway.
Zebrafish anterior segment mesenchyme progenitors are defined by function of tfap2a but not sox10.
Title: Zebrafish anterior segment mesenchyme progenitors are defined by function of tfap2a but not sox10.
Kctd15 regulates nephron segment development by repressing Tfap2a activity.
Title: Kctd15 regulates nephron segment development by repressing Tfap2a activity.
Insights into the genetic control of differentiation, where tfap2a is essential for regulating a suite of segment transporter traits at the final tier of zebrafish pronephros ontogeny. These findings have relevance for understanding renal birth defects, as well as efforts to recapitulate nephrogenesis in vivo to facilitate drug discovery and regenerative therapies.
Title: Tfap2a is a novel gatekeeper of nephron differentiation during kidney development.
We genetically ablate the NC using double mutants of tfap2a;tfap2c or remove specific subsets of the NC with sox10 and mitfa knockouts and characterise genome-wide gene expression levels across multiple time points.
Title: The gene regulatory basis of genetic compensation during neural crest induction.
Genetic interaction between tfap2a and mitfa suggest that the factors encoded by these genes regulate shared targets in melanocytes, possibly within single or converging pathways.
Title: TFAP2 paralogs regulate melanocyte differentiation in parallel with MITF.
these data support a model in which Tfap2a, acting through Bmp7a, modulates Fgf and Notch signaling to control the duration, amount and speed of SAG neural development.
Title: Tfap2a promotes specification and maturation of neurons in the inner ear through modulation of Bmp, Fgf and notch signaling.
Prdm1a directly binds and activates a tfap2a enhancer at the NPB
Title: Prdm1a directly activates foxd3 and tfap2a during zebrafish neural crest specification.
Low Bmp activates expression of the transcription factor Tfap2a as part of a gene regulatory network that coordinates development of neural crest, preplacodal ectoderm and individual placodes in zebrafish.
Title: A gene network that coordinates preplacodal competence and neural crest specification in zebrafish.
tfap2a and foxd3 are expressed during gastrulation prior to neural crest induction in distinct, complementary, domains; tfap2a is expressed in the ventral non-neural ectoderm and foxd3 in the dorsal mesendoderm and ectoderm
Title: Tfap2a and Foxd3 regulate early steps in the development of the neural crest progenitor population.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fc22f05.y1 (e-PCR)
- UniSTS:193105

AI722745 (e-PCR)
- UniSTS:205985

fc31a07.y1 (e-PCR)
- UniSTS:193507

fb83f04.x1 (e-PCR)
- UniSTS:203498

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IGI Inferred from Genetic Interaction more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	TAS Traceable Author Statement more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in anatomical structure development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cartilage development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within developmental pigmentation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within developmental pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ectodermal placode development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within ectodermal placode formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hindbrain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within iridophore differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within melanocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within_positive_effect melanocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within melanocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect melanocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural crest cell development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neural crest cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neural crest cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within olfactory placode development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within otic placode formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within otic vesicle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within peripheral nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pigmentation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pronephric nephron tubule epithelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within retina development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transcription factor AP-2-alpha

Names: lockjaw; low; mob; mont blanc

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001319158.1 → NP_001306087.1 transcription factor AP-2-alpha isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region which results in the use of alternate start codon, compared to isoform 1. The encoded isoform (2) is shorter and has a disntinct N-terminus, compared to isoform 1.

Source sequence(s)

LO018134, LO018137

UniProtKB/TrEMBL

A0A8M1P295, F1QUT4

Related

ENSDARP00000076787.3, ENSDART00000082351.5

Conserved Domains (1) summary

pfam03299
Location:209 → 409

TF_AP-2; Transcription factor AP-2
NM_001319159.2 → NP_001306088.1 transcription factor AP-2-alpha isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region which results in the use of an alternate start codon compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

LO018134, LO018137

UniProtKB/TrEMBL

A0A8M1P8F8, Q6NYI3

Related

ENSDARP00000148170.1, ENSDART00000183624.1

Conserved Domains (1) summary

pfam03299
Location:197 → 397

TF_AP-2; Transcription factor AP-2
NM_176859.4 → NP_789829.2 transcription factor AP-2-alpha isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

EH587281, EH590405, LO018134, LO018137

UniProtKB/TrEMBL

A0A2R8QRQ5, A0A8M1PAC7

Related

ENSDARP00000157668.1, ENSDART00000186660.1

Conserved Domains (1) summary

pfam03299
Location:222 → 422

TF_AP-2; Transcription factor AP-2

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007135.7 Reference GRCz11 Primary Assembly

Range

8721676..8732517 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005162558.4 → XP_005162615.1 transcription factor AP-2-alpha isoform X1

UniProtKB/TrEMBL

A0A8M2B9E2

Conserved Domains (1) summary

pfam03299
Location:229 → 429

TF_AP-2; Transcription factor AP-2