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Pip4k2c phosphatidylinositol-5-phosphate 4-kinase type 2 gamma [ Rattus norvegicus (Norway rat) ]

Gene ID: 140607, updated on 11-Apr-2024

Summary

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Official Symbol
Pip4k2cprovided by RGD
Official Full Name
phosphatidylinositol-5-phosphate 4-kinase type 2 gammaprovided by RGD
Primary source
RGD:621711
See related
Ensembl:ENSRNOG00000005138 AllianceGenome:RGD:621711
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pip5k2c
Summary
Enables 1-phosphatidylinositol-4-phosphate 5-kinase activity. Predicted to be involved in several processes, including 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity; and positive regulation of autophagosome assembly. Located in endoplasmic reticulum. Orthologous to human PIP4K2C (phosphatidylinositol-5-phosphate 4-kinase type 2 gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 237.9), Thymus (RPKM 129.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q22
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (64905322..64920380, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (63020004..63035086, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (70483948..70498995, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 25 Neighboring gene uncharacterized LOC134479708 Neighboring gene deltex E3 ubiquitin ligase 3 Neighboring gene kinesin family member 5A Neighboring gene dynactin subunit 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A novel phosphatidylinositol-5-phosphate 4-kinase (phosphatidylinositol-phosphate kinase IIgamma) is phosphorylated in the endoplasmic reticulum in response to mitogenic signals. Itoh T, et al. J Biol Chem, 1998 Aug 7. PMID 9685379
  2. The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site. Clarke JH, et al. Biochem J, 2015 Mar 1. PMID 25495341, Free PMC Article
  3. Evolutionarily conserved structural changes in phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) isoforms are responsible for differences in enzyme activity and localization. Clarke JH, et al. Biochem J, 2013 Aug 15. PMID 23758345, Free PMC Article
  4. PI(5)P regulates autophagosome biogenesis. Vicinanza M, et al. Mol Cell, 2015 Jan 22. PMID 25578879, Free PMC Article
  5. A protein-protein interaction network of transcription factors acting during liver cell proliferation. Gao J, et al. Genomics, 2008 Apr. PMID 18255255

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables 1-phosphatidylinositol-5-phosphate 4-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of insulin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phosphatidylinositol biosynthetic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of autophagosome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of autophagosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in autophagosome IEA
Inferred from Electronic Annotation
more info
  
located_in autophagosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
Names
PI(5)P 4-kinase type II gamma
PIP4KII-gamma
phosphatidylinositol 5-phosphate 4-kinase type II gamma
phosphatidylinositol-4-phosphate 5-kinase, type II, gamma
NP_536728.2
XP_038934243.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080480.2 → NP_536728.2  phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

    See identical proteins and their annotated locations for NP_536728.2

    Status: VALIDATED

    Source sequence(s)
    AF030558, BF556960, BI275922, CO400462, CV115612, DN934555
    UniProtKB/Swiss-Prot
    O88370
    UniProtKB/TrEMBL
    A6HQT5, G3V9W5
    Related
    ENSRNOP00000061758.1, ENSRNOT00000067774.4
    Conserved Domains (1) summary
    cd17311
    Location:46 → 418
    PIPKc_PIP5K2C; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (PIP5K2C) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    64905322..64920380 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078315.2 → XP_038934243.1  phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X1

    UniProtKB/Swiss-Prot
    O88370
    Conserved Domains (1) summary
    cl28923
    Location:1 → 349
    PIPKc; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88370.1 GenPept UniProtKB/Swiss-Prot:O88370

Gene LinkOut

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