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Ackr2 atypical chemokine receptor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 140473, updated on 11-Apr-2024

Summary

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Official Symbol
Ackr2provided by RGD
Official Full Name
atypical chemokine receptor 2provided by RGD
Primary source
RGD:620323
See related
Ensembl:ENSRNOG00000019472 AllianceGenome:RGD:620323
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
D6; Ccbp2
Summary
Predicted to enable C-C chemokine binding activity; C-C chemokine receptor activity; and scavenger receptor activity. Predicted to be involved in several processes, including calcium-mediated signaling; cell chemotaxis; and positive regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within signal transduction. Predicted to be located in several cellular components, including actin filament; cytosol; and nucleus. Predicted to be active in external side of plasma membrane. Orthologous to human ACKR2 (atypical chemokine receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 26.4), Liver (RPKM 26.3) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ackr2 in Genome Data Viewer
Location:
8q32
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (130438703..130451106)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (121559563..121573633)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (130526521..130543566)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene hedgehog acyltransferase-like Neighboring gene coiled-coil domain containing 13 Neighboring gene HIG1 hypoxia inducible domain family, member 1A Neighboring gene cytochrome P450 family 8 subfamily B member 1 Neighboring gene poly(rC) binding protein 2 like 1 Neighboring gene KRAB box domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular cloning and expression of a novel rat CC-chemokine receptor (rCCR10rR) that binds MCP-1 and MIP-1beta with high affinity. Bonini JA, et al. DNA Cell Biol, 1997 Sep. PMID 9324304
  2. Chemokines: a new classification system and their role in immunity. Zlotnik A, et al. Immunity, 2000 Feb. PMID 10714678
  3. Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3. Bonini JA, et al. DNA Cell Biol, 1997 Oct. PMID 9364936
  4. β-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6. Borroni EM, et al. Sci Signal, 2013 Apr 30. PMID 23633677
  5. Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5. Nibbs RJ, et al. J Biol Chem, 1997 May 9. PMID 9139699

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC105345

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables C-C chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables C-C chemokine binding IEA
Inferred from Electronic Annotation
more info
  
enables C-C chemokine binding ISO
Inferred from Sequence Orthology
more info
  
enables C-C chemokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables C-C chemokine receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables C-C chemokine receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables chemokine receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables scavenger receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables scavenger receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables scavenger receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in actin filament IEA
Inferred from Electronic Annotation
more info
  
located_in actin filament ISO
Inferred from Sequence Orthology
more info
  
located_in actin filament ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in recycling endosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
atypical chemokine receptor 2
Names
C-C chemokine receptor D6
CC-chemokine-binding receptor JAB61
CCR10-related receptor
chemokine-binding protein 2
chemokine-binding protein D6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_078621.2 → NP_511176.2  atypical chemokine receptor 2

    See identical proteins and their annotated locations for NP_511176.2

    Status: PROVISIONAL

    Source sequence(s)
    BC086449
    UniProtKB/Swiss-Prot
    O09027
    UniProtKB/TrEMBL
    A0A8I6G8C2, A6I464, Q5U1W0
    Conserved Domains (1) summary
    cd15188
    Location:46 → 323
    7tmA_ACKR2_D6; atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    130438703..130451106
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039080719.2 → XP_038936647.1  atypical chemokine receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    O09027
    UniProtKB/TrEMBL
    A0A8I6G8C2, A6I464, Q5U1W0
    Related
    ENSRNOP00000026343.1
    Conserved Domains (1) summary
    cd15188
    Location:46 → 323
    7tmA_ACKR2_D6; atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_039080721.2 → XP_038936649.1  atypical chemokine receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    O09027
    UniProtKB/TrEMBL
    A0A8I6G8C2, A6I464, Q5U1W0
    Conserved Domains (1) summary
    cd15188
    Location:46 → 323
    7tmA_ACKR2_D6; atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. XM_039080718.2 → XP_038936646.1  atypical chemokine receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    O09027
    UniProtKB/TrEMBL
    A0A8I6G8C2, A6I464, Q5U1W0
    Related
    ENSRNOP00000081718.1
    Conserved Domains (1) summary
    cd15188
    Location:46 → 323
    7tmA_ACKR2_D6; atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O09027.1 GenPept UniProtKB/Swiss-Prot:O09027

Gene LinkOut

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