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CRHBP corticotropin releasing hormone binding protein [ Homo sapiens (human) ]

Gene ID: 1393, updated on 4-Jan-2025

Summary

Official Symbol
CRHBPprovided by HGNC
Official Full Name
corticotropin releasing hormone binding proteinprovided by HGNC
Primary source
HGNC:HGNC:2356
See related
Ensembl:ENSG00000145708 MIM:122559; AllianceGenome:HGNC:2356
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRFBP; CRF-BP
Summary
Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. [provided by RefSeq, Jul 2008]
Expression
Biased expression in liver (RPKM 36.1), kidney (RPKM 16.1) and 6 other tissues See more
Orthologs
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Genomic context

See CRHBP in Genome Data Viewer
Location:
5q13.3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (76953045..76981159)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (77434877..77462968)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (76248870..76265296)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 208, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22698 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:76166173-76166870 Neighboring gene S100 calcium binding protein Z Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:76184471-76184971 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:76221500-76221673 Neighboring gene RNA, U6atac small nuclear 36, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:76249596-76250282 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:76325887-76326466 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:76326467-76327046 Neighboring gene angiogenic factor with G-patch and FHA domains 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16108 Neighboring gene zinc finger BED-type containing 3 Neighboring gene small nucleolar RNA, H/ACA box 47

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables corticotropin-releasing hormone binding  
enables corticotropin-releasing hormone binding PubMed 
enables corticotropin-releasing hormone binding PubMed 
enables peptide binding  
enables protein binding PubMed 
Process Evidence Code Pubs
involved_in behavioral response to ethanol PubMed 
involved_in cellular response to cAMP  
involved_in cellular response to calcium ion  
involved_in cellular response to cocaine  
involved_in cellular response to estradiol stimulus PubMed 
involved_in cellular response to estrogen stimulus PubMed 
involved_in cellular response to gonadotropin-releasing hormone  
involved_in cellular response to potassium ion PubMed 
involved_in cellular response to tumor necrosis factor PubMed 
involved_in cellular response to xenobiotic stimulus  
involved_in female pregnancy PubMed 
involved_in female pregnancy PubMed 
involved_in hormone-mediated signaling pathway  
involved_in hormone-mediated signaling pathway PubMed 
involved_in inflammatory response PubMed 
involved_in learning or memory PubMed 
involved_in negative regulation of corticotropin secretion  
involved_in negative regulation of corticotropin secretion PubMed 
involved_in negative regulation of corticotropin-releasing hormone receptor activity PubMed 
involved_in regulated exocytosis PubMed 
involved_in regulation of NMDA receptor activity  
involved_in regulation of cellular response to stress PubMed 
involved_in regulation of corticotropin secretion PubMed 
involved_in signal transduction PubMed 
involved_in synaptic transmission, dopaminergic  
Component Evidence Code Pubs
NOT located_in Golgi apparatus PubMed 
located_in axon terminus  
located_in dendrite  
located_in dense core granule  
NOT located_in endoplasmic reticulum PubMed 
located_in extracellular region  
is_active_in extracellular space  
located_in extracellular space PubMed 
located_in microtubule  
located_in multivesicular body  
located_in nucleus  
located_in perikaryon  
located_in secondary lysosome  
located_in secretory granule PubMed 
located_in varicosity  

General protein information

Preferred Names
corticotropin-releasing factor-binding protein
Names
CRF-binding protein
CRH-BP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001882.4NP_001873.2  corticotropin-releasing factor-binding protein

    See identical proteins and their annotated locations for NP_001873.2

    Status: REVIEWED

    Source sequence(s)
    AW451896, BC018038, CB959505
    Consensus CDS
    CCDS4034.1
    UniProtKB/Swiss-Prot
    P24387, Q53F32, Q6FHT5
    Related
    ENSP00000274368.4, ENST00000274368.9
    Conserved Domains (1) summary
    pfam05428
    Location:10307
    CRF-BP; Corticotropin-releasing factor binding protein (CRF-BP)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    76953045..76981159
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047416736.1XP_047272692.1  corticotropin-releasing factor-binding protein isoform X1

RNA

  1. XR_948235.4 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    77434877..77462968
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_008487082.1 RNA Sequence

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