Ephb2 Eph receptor B2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ephb2provided by MGI
Official Full Name: Eph receptor B2provided by MGI
Primary source: MGI:MGI:99611
See related: Ensembl:ENSMUSG00000028664 AllianceGenome:MGI:99611
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Drt; Erk; Nuk; Cek5; Hek5; Qek5; Sek3; ETECK; Prkm5; Tyro5
Summary: This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors consist of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. The encoded receptor preferentially binds membrane-bound ephrin-B ligands and is involved in nervous system and vascular development. This gene is used as a marker of intestinal stem cells. Homozygous knockout mice for this gene exhibit impaired axon guidance and vestibular function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Expression: Broad expression in whole brain E14.5 (RPKM 18.7), CNS E14 (RPKM 13.6) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D3; 4 69.0 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (136374850..136563637, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (136647536..136836326, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Peripheral T-cell responses of EphB2- and EphB3-deficient mice in a model of collagen-induced arthritis.
Title: Peripheral T-cell responses of EphB2- and EphB3-deficient mice in a model of collagen-induced arthritis.
EphB2 promotes enteric nitrergic hyperinnervation and neurogenic inflammation in DSS-induced chronic colitis in mice.
Title: EphB2 promotes enteric nitrergic hyperinnervation and neurogenic inflammation in DSS-induced chronic colitis in mice.
EphB2-dependent prefrontal cortex activation promotes long-range social approach and partner responsiveness.
Title: EphB2-dependent prefrontal cortex activation promotes long-range social approach and partner responsiveness.
Divergent Roles of Ephrin-B2/EphB4 Guidance System in Pulmonary Hypertension.
Title: Divergent Roles of Ephrin-B2/EphB4 Guidance System in Pulmonary Hypertension.
RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.
Title: RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.
Key role for EphB2 receptor in kidney fibrosis.
Title: Key role for EphB2 receptor in kidney fibrosis.
Thymus aging in mice deficient in either EphB2 or EphB3, two master regulators of thymic epithelium development.
Title: Thymus aging in mice deficient in either EphB2 or EphB3, two master regulators of thymic epithelium development.
The Ephb2 Receptor Uses Homotypic, Head-to-Tail Interactions within Its Ectodomain as an Autoinhibitory Control Mechanism.
Title: The Ephb2 Receptor Uses Homotypic, Head-to-Tail Interactions within Its Ectodomain as an Autoinhibitory Control Mechanism.
Sex-dependent role for EPHB2 in brain development and autism-associated behavior.
Title: Sex-dependent role for EPHB2 in brain development and autism-associated behavior.
Ligand-Dependent and Ligand-Independent Effects of Ephrin-B2-EphB4 Signaling in Melanoma Metastatic Spine Disease.
Title: Ligand-Dependent and Ligand-Independent Effects of Ephrin-B2-EphB4 Signaling in Melanoma Metastatic Spine Disease.

Submit: New GeneRIF Correction See all GeneRIFs (96)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation
Endonuclease-mediated (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ephb2 (e-PCR), detects polymorphism
- UniSTS:495888

MARC_17495-17496:1030378704:1 (e-PCR)
- UniSTS:268320

BB230762 (e-PCR)
- UniSTS:207695

L25890 (e-PCR)
- UniSTS:159311

RH131438 (e-PCR)
- UniSTS:214721

Ephb2 (e-PCR), detects polymorphism
- UniSTS:527339

Ephb2 (e-PCR), detects polymorphism
- UniSTS:266992

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables amyloid-beta binding	IPI Inferred from Physical Interaction more info	PubMed
enables axon guidance receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables ephrin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane-ephrin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane-ephrin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane-ephrin receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell activation	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within animal organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axon guidance	IDA Inferred from Direct Assay more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonal fasciculation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of axonogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within camera-type eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within central nervous system projection neuron axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in commissural neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in corpus callosum development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendritic spine development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dendritic spine morphogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in dendritic spine morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ephrin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ephrin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in ephrin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in hindbrain tangential cell migration	ISO Inferred from Sequence Orthology more info
involved_in inner ear morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in learning or memory	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of NMDA glutamate receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Ras protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of axonogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytokine production involved in inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neuron projection retraction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within optic nerve morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NMDA glutamate receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of immunoglobulin production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of long-term neuronal synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of long-term synaptic potentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to cell surface	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic plasticity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic membrane assembly	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of T-helper 17 type immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect regulation of autophagosome assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of axonogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of behavioral fear response	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood coagulation	ISO Inferred from Sequence Orthology more info
involved_in regulation of body fluid levels	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of filopodium assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of neuronal synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in regulation of synapse assembly	EXP Inferred from Experiment more info	PubMed
involved_in regulation of synapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retinal ganglion cell axon guidance	IDA Inferred from Direct Assay more info	PubMed
involved_in roof of mouth development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tight junction assembly	ISO Inferred from Sequence Orthology more info
involved_in trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in urogenital system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated intercellular transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in hippocampal mossy fiber to CA3 synapse	IC Inferred by Curator more info	PubMed
is_active_in hippocampal mossy fiber to CA3 synapse	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed
located_in postsynapse	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic membrane	IEP Inferred from Expression Pattern more info	PubMed
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IEP Inferred from Expression Pattern more info	PubMed
located_in synapse	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: ephrin type-B receptor 2

Names: neural kinase; nuk receptor tyrosine kinase; tyrosine-protein kinase receptor EPH-3; tyrosine-protein kinase receptor SEK-3

NP_001277682.1

EC 2.7.10.1

NP_034272.1

EC 2.7.10.1

XP_006538594.1

EC 2.7.10.1

XP_006538596.1

EC 2.7.10.1

XP_006538597.1

EC 2.7.10.1

XP_030109050.1

EC 2.7.10.1

XP_030109051.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290753.2 → NP_001277682.1 ephrin type-B receptor 2 isoform 1 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AL671173, BC062924, CJ180821

Consensus CDS

CCDS71498.1

UniProtKB/Swiss-Prot

P54763

Related

ENSMUSP00000058135.8, ENSMUST00000059287.14

Conserved Domains (5) summary

cd05065
Location:617 → 885

PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors

cd09552
Location:911 → 981

SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors

cd10477
Location:19 → 196

EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2

pfam00041
Location:437 → 520

fn3; Fibronectin type III domain

pfam14575
Location:549 → 617

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
NM_010142.4 → NP_034272.1 ephrin type-B receptor 2 isoform 2 precursor

See identical proteins and their annotated locations for NP_034272.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter by an amino acid, compared to isoform 1.

Source sequence(s)

AL671173, BC043088, CJ180821

Consensus CDS

CCDS18809.1

UniProtKB/Swiss-Prot

A3KG00, A3KG01, A3KG02, A3KG89, A3KG90, P54763, Q62213, Q6GTQ7, Q6P5F1, Q9QVY4

Related

ENSMUSP00000101471.3, ENSMUST00000105845.9

Conserved Domains (5) summary

cd05065
Location:616 → 884

PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors

cd09552
Location:910 → 980

SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors

cd10477
Location:19 → 196

EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2

pfam00041
Location:437 → 519

fn3; Fibronectin type III domain

pfam14575
Location:548 → 616

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

136374850..136563637 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006538534.4 → XP_006538597.1 ephrin type-B receptor 2 isoform X1

Conserved Domains (5) summary

cd05065
Location:618 → 886

PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors

cd09552
Location:912 → 982

SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors

cd10477
Location:19 → 196

EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2

pfam00041
Location:437 → 520

fn3; Fibronectin type III domain

pfam14575
Location:549 → 618

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
XM_030253190.2 → XP_030109050.1 ephrin type-B receptor 2 isoform X3

Conserved Domains (5) summary

cd05065
Location:595 → 863

PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors

cd09552
Location:889 → 959

SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors

cd10477
Location:1 → 173

EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2

pfam00041
Location:414 → 497

fn3; Fibronectin type III domain

pfam14575
Location:526 → 595

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
XM_030253191.2 → XP_030109051.1 ephrin type-B receptor 2 isoform X5

Conserved Domains (5) summary

cd05065
Location:585 → 853

PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors

cd09552
Location:879 → 949

SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors

cd10477
Location:19 → 196

EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2

pfam00041
Location:326 → 419

fn3; Fibronectin type III domain

pfam14575
Location:517 → 585

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
XM_006538533.5 → XP_006538596.1 ephrin type-B receptor 2 isoform X4

Conserved Domains (5) summary

cd05065
Location:586 → 854

PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors

cd09552
Location:880 → 950

SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors

cd10477
Location:19 → 196

EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2

pfam00041
Location:326 → 419

fn3; Fibronectin type III domain

pfam14575
Location:517 → 586

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
XM_006538531.5 → XP_006538594.1 ephrin type-B receptor 2 isoform X2

UniProtKB/Swiss-Prot

P54763

Related

ENSMUSP00000101472.3, ENSMUST00000105846.9

Conserved Domains (5) summary

cd05065
Location:617 → 885

PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors

cd09552
Location:911 → 981

SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors

cd10477
Location:19 → 196

EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2

pfam00041
Location:437 → 519

fn3; Fibronectin type III domain

pfam14575
Location:548 → 617

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain