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Epha2 Eph receptor A2 [ Mus musculus (house mouse) ]

Gene ID: 13836, updated on 4-Jan-2025

Summary

Official Symbol
Epha2provided by MGI
Official Full Name
Eph receptor A2provided by MGI
Primary source
MGI:MGI:95278
See related
Ensembl:ENSMUSG00000006445 AllianceGenome:MGI:95278
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Eck; Myk2; Sek2; Sek-2
Summary
Predicted to enable growth factor binding activity; molecular function activator activity; and transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including lens fiber cell morphogenesis; mammary gland epithelium development; and osteoclast differentiation. Acts upstream of or within several processes, including blood vessel morphogenesis; nervous system development; and notochord development. Located in cell surface. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; endometrium; and limb. Used to study cataract 6 multiple types. Human ortholog(s) of this gene implicated in cataract 6 multiple types. Orthologous to human EPHA2 (EPH receptor A2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in lung adult (RPKM 25.3), small intestine adult (RPKM 22.7) and 19 other tissues See more
Orthologs
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Genomic context

See Epha2 in Genome Data Viewer
Location:
4 D3; 4 73.67 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (141028532..141056695)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (141301221..141329384)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 19 Neighboring gene predicted gene, 52686 Neighboring gene STARR-seq mESC enhancer starr_11896 Neighboring gene predicted gene 13056 Neighboring gene STARR-seq mESC enhancer starr_11899 Neighboring gene STARR-seq mESC enhancer starr_11901 Neighboring gene predicted gene 13076 Neighboring gene family with sequence similarity 131, member C

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Items 1 - 25 of 26
Function Evidence Code Pubs
enables ATP binding  
enables GPI-linked ephrin receptor activity  
enables boss receptor activity  
enables brain-derived neurotrophic factor receptor activity  
enables epidermal growth factor receptor activity  
enables fibroblast growth factor receptor activity  
enables growth factor binding  
enables growth factor binding  
enables hepatocyte growth factor receptor activity  
enables histone H2AXY142 kinase activity  
enables histone H3Y41 kinase activity  
enables insulin receptor activity  
enables insulin-like growth factor receptor activity  
enables macrophage colony-stimulating factor receptor activity  
enables molecular function activator activity  
enables placental growth factor receptor activity  
enables platelet-derived growth factor alpha-receptor activity  
enables platelet-derived growth factor beta-receptor activity  
enables protein binding PubMed 
enables protein tyrosine kinase collagen receptor activity  
enables stem cell factor receptor activity  
enables transmembrane receptor protein tyrosine kinase activity  
enables transmembrane receptor protein tyrosine kinase activity  
enables transmembrane receptor protein tyrosine kinase activity  
enables transmembrane-ephrin receptor activity  
enables vascular endothelial growth factor receptor activity  
Items 1 - 25 of 26
Items 1 - 25 of 79
Process Evidence Code Pubs
involved_in Kit signaling pathway  
involved_in activation of GTPase activity  
involved_in activation of GTPase activity  
acts_upstream_of_or_within axial mesoderm formation PubMed 
acts_upstream_of_or_within blood vessel development PubMed 
acts_upstream_of_or_within blood vessel endothelial cell proliferation involved in sprouting angiogenesis PubMed 
acts_upstream_of_or_within blood vessel morphogenesis PubMed 
involved_in bone remodeling PubMed 
involved_in brain-derived neurotrophic factor receptor signaling pathway  
involved_in branching involved in mammary gland duct morphogenesis PubMed 
involved_in cAMP metabolic process  
involved_in cAMP metabolic process  
involved_in cell adhesion  
involved_in cell chemotaxis  
involved_in cell chemotaxis  
involved_in cell migration  
involved_in cell migration  
involved_in cell motility  
involved_in cell motility  
involved_in cell surface receptor protein tyrosine kinase signaling pathway  
involved_in chromatin remodeling  
involved_in collagen-activated tyrosine kinase receptor signaling pathway  
acts_upstream_of_or_within defense response to Gram-positive bacterium PubMed 
acts_upstream_of_or_within ephrin receptor signaling pathway PubMed 
involved_in ephrin receptor signaling pathway PubMed 
involved_in ephrin receptor signaling pathway  
involved_in epidermal growth factor receptor signaling pathway  
involved_in fibroblast growth factor receptor signaling pathway  
involved_in hepatocyte growth factor receptor signaling pathway  
acts_upstream_of_or_within inflammatory response PubMed 
involved_in insulin receptor signaling pathway  
involved_in insulin-like growth factor receptor signaling pathway  
involved_in intrinsic apoptotic signaling pathway in response to DNA damage  
involved_in intrinsic apoptotic signaling pathway in response to DNA damage  
involved_in keratinocyte differentiation  
involved_in keratinocyte differentiation  
involved_in lens fiber cell morphogenesis PubMed 
involved_in macrophage colony-stimulating factor signaling pathway  
involved_in mammary gland epithelial cell proliferation PubMed 
involved_in multicellular organism development  
acts_upstream_of_or_within negative regulation of angiogenesis PubMed 
acts_upstream_of_or_within negative regulation of chemokine production PubMed 
acts_upstream_of_or_within negative regulation of cytokine production PubMed 
acts_upstream_of_or_within negative regulation of lymphangiogenesis PubMed 
acts_upstream_of_or_within neural tube development PubMed 
acts_upstream_of_or_within neuron differentiation PubMed 
acts_upstream_of_or_within neuron differentiation PubMed 
acts_upstream_of_or_within notochord cell development PubMed 
acts_upstream_of_or_within notochord formation PubMed 
acts_upstream_of_or_within notochord formation PubMed 
acts_upstream_of_or_within notochord morphogenesis PubMed 
involved_in osteoblast differentiation PubMed 
involved_in osteoclast differentiation PubMed 
acts_upstream_of_or_within pericyte cell differentiation PubMed 
involved_in platelet-derived growth factor receptor-alpha signaling pathway  
involved_in platelet-derived growth factor receptor-beta signaling pathway  
involved_in positive regulation of bicellular tight junction assembly  
involved_in positive regulation of bicellular tight junction assembly  
involved_in positive regulation of cell migration  
involved_in positive regulation of cell migration  
involved_in positive regulation of protein localization to plasma membrane  
involved_in positive regulation of protein localization to plasma membrane  
acts_upstream_of_or_within post-anal tail morphogenesis PubMed 
involved_in protein localization to plasma membrane  
involved_in protein localization to plasma membrane  
involved_in regulation of ERK1 and ERK2 cascade  
involved_in regulation of ERK1 and ERK2 cascade  
involved_in regulation of angiogenesis PubMed 
involved_in regulation of blood vessel endothelial cell migration PubMed 
involved_in regulation of cell adhesion mediated by integrin  
involved_in regulation of cell adhesion mediated by integrin  
involved_in regulation of lamellipodium assembly  
involved_in regulation of lamellipodium assembly  
involved_in response to growth factor  
involved_in response to growth factor  
acts_upstream_of_or_within skeletal system development PubMed 
involved_in vascular endothelial growth factor receptor-1 signaling pathway  
involved_in vascular endothelial growth factor signaling pathway  
acts_upstream_of_or_within vasculogenesis PubMed 
Items 1 - 25 of 79
Component Evidence Code Pubs
located_in cell surface PubMed 
located_in cell surface  
located_in focal adhesion  
located_in focal adhesion  
located_in lamellipodium  
located_in lamellipodium  
located_in lamellipodium membrane  
located_in leading edge membrane  
located_in leading edge membrane  
is_active_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane  
part_of receptor complex  
located_in ruffle membrane  
located_in tight junction  
located_in tight junction  

General protein information

Preferred Names
ephrin type-A receptor 2
Names
epithelial cell kinase
tyrosine-protein kinase receptor ECK
tyrosine-protein kinase receptor MPK-5
tyrosine-protein kinase receptor SEK-2
NP_034269.2
XP_006538591.1
XP_036019541.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010139.3NP_034269.2  ephrin type-A receptor 2 precursor

    See identical proteins and their annotated locations for NP_034269.2

    Status: VALIDATED

    Source sequence(s)
    AK144202, AW457468, CJ088701
    Consensus CDS
    CCDS18869.1
    UniProtKB/Swiss-Prot
    Q03145, Q3UNI2, Q60633, Q62212
    Related
    ENSMUSP00000006614.3, ENSMUST00000006614.3
    Conserved Domains (8) summary
    cd09543
    Location:903972
    SAM_EPH-A2; SAM domain of EPH-A2 family of tyrosine kinase receptors
    smart00454
    Location:903969
    SAM; Sterile alpha motif
    cd10480
    Location:27200
    EphR_LBD_A2; Ligand Binding Domain of Ephrin type-A Receptor 2
    cd00063
    Location:440527
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:331425
    fn3; Fibronectin type III domain
    pfam07714
    Location:618872
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:579609
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl21453
    Location:608876
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    141028532..141056695
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163648.1XP_036019541.1  ephrin type-A receptor 2 isoform X1

    Conserved Domains (4) summary
    cd09543
    Location:655724
    SAM_EPH-A2; SAM domain of EPH-A2 family of tyrosine kinase receptors
    pfam00041
    Location:191272
    fn3; Fibronectin type III domain
    pfam14575
    Location:322363
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl21453
    Location:360628
    PKc_like; Protein Kinases, catalytic domain
  2. XM_006538528.5XP_006538591.1  ephrin type-A receptor 2 isoform X2

    Conserved Domains (4) summary
    cd09543
    Location:629698
    SAM_EPH-A2; SAM domain of EPH-A2 family of tyrosine kinase receptors
    pfam00041
    Location:165243
    fn3; Fibronectin type III domain
    pfam14575
    Location:298335
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl21453
    Location:334602
    PKc_like; Protein Kinases, catalytic domain
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