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Elk4 ELK4, member of ETS oncogene family [ Mus musculus (house mouse) ]

Gene ID: 13714, updated on 11-Apr-2024

Summary

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Official Symbol
Elk4provided by MGI
Official Full Name
ELK4, member of ETS oncogene familyprovided by MGI
Primary source
MGI:MGI:102853
See related
Ensembl:ENSMUSG00000026436 AllianceGenome:MGI:102853
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sap1; SAP-1; 2310011G17Rik; A130026I01Rik
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Predicted to be involved in cell differentiation; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within histone H3 deacetylation. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; and retina. Orthologous to human ELK4 (ETS transcription factor ELK4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 13.6), spleen adult (RPKM 6.7) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 E4; 1 57.24 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (131935129..131954186)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (132007577..132026448)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02229 Neighboring gene nuclear casein kinase and cyclin-dependent kinase substrate 1 Neighboring gene solute carrier family 45, member 3 Neighboring gene STARR-positive B cell enhancer mm9_chr1:133879500-133879800 Neighboring gene STARR-positive B cell enhancer ABC_E5800 Neighboring gene STARR-positive B cell enhancer ABC_E5801 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:133904735-133904947 Neighboring gene STARR-positive B cell enhancer ABC_E10036 Neighboring gene STARR-positive B cell enhancer ABC_E11086 Neighboring gene STARR-positive B cell enhancer ABC_E5802 Neighboring gene major facilitator superfamily domain containing 4A Neighboring gene RIKEN cDNA 4833413N01 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:133998691-133998892 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:133998935-133999044 Neighboring gene predicted gene, 37120

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Raf signaling but not the ERK effector SAP-1 is required for regulatory T cell development. Willoughby JE, et al. J Immunol, 2007 Nov 15. PMID 17982074, Free PMC Article
  2. Ternary complex factor SAP-1 is required for Erk-mediated thymocyte positive selection. Costello PS, et al. Nat Immunol, 2004 Mar. PMID 14770179
  3. CircELK4 Contributes to Lupus Nephritis by Acting as a miR-27b-3p Sponge to Regulate STING/IRF3/IFN-I Signaling. Xu ZQ, et al. Inflammation, 2021 Oct. PMID 34091806
  4. ERK Signaling Controls Innate-like CD8(+) T Cell Differentiation via the ELK4 (SAP-1) and ELK1 Transcription Factors. Maurice D, et al. J Immunol, 2018 Sep 15. PMID 30068599, Free PMC Article
  5. Elk3 deficiency causes transient impairment in post-natal retinal vascular development and formation of tortuous arteries in adult murine retinae. Weinl C, et al. PLoS One, 2014. PMID 25203538, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CircELK4 Contributes to Lupus Nephritis by Acting as a miR-27b-3p Sponge to Regulate STING/IRF3/IFN-I Signaling.
    Title: CircELK4 Contributes to Lupus Nephritis by Acting as a miR-27b-3p Sponge to Regulate STING/IRF3/IFN-I Signaling.
  2. These data establish that low-level ERK signaling through ELK4 (and ELK1) promotes innate-like alphabeta CD8(+) T cell differentiation, tuning conventional versus innate-like development.
    Title: ERK Signaling Controls Innate-like CD8(+) T Cell Differentiation via the ELK4 (SAP-1) and ELK1 Transcription Factors.
  3. Dok-4 can target Elk-4 activity through multiple mechanisms, including binding of the transactivation domain, nuclear exclusion and protein destabilization.
    Title: Binding and inhibition of the ternary complex factor Elk-4/Sap1 by the adapter protein Dok-4.
  4. MKL1/2 and ELK4 co-regulate distinct serum response factor (SRF) transcription programs in macrophages.
    Title: MKL1/2 and ELK4 co-regulate distinct serum response factor (SRF) transcription programs in macrophages.
  5. Data show that Elk-1 and Net do not contribute significantly to thymocyte development in the presence of SAP-1.
    Title: Ternary complex factors SAP-1 and Elk-1, but not net, are functionally equivalent in thymocyte development.
  6. T cell positive selection, and ERK signaling to SAP-1 is not required for the suppressive activity of T(reg) cells.
    Title: Raf signaling but not the ERK effector SAP-1 is required for regulatory T cell development.
  7. SAP-1 is required for Erk-mediated transcriptional events in thymocyte development.
    Title: Ternary complex factor SAP-1 is required for Erk-mediated thymocyte positive selection.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ETS domain-containing protein Elk-4
Names
SRF accessory protein 1
serum response factor accessory protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001376954.1 → NP_001363883.1  ETS domain-containing protein Elk-4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC107837
    UniProtKB/Swiss-Prot
    A6H693, P41158
    Conserved Domains (2) summary
    smart00413
    Location:17 → 88
    ETS; erythroblast transformation specific domain
    PHA03247
    Location:170 → 349
    PHA03247; large tegument protein UL36; Provisional

  2. NM_001376955.1 → NP_001363884.1  ETS domain-containing protein Elk-4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC107837
    UniProtKB/Swiss-Prot
    A6H693, P41158
    Conserved Domains (2) summary
    smart00413
    Location:17 → 88
    ETS; erythroblast transformation specific domain
    PHA03247
    Location:170 → 349
    PHA03247; large tegument protein UL36; Provisional

  3. NM_001376956.1 → NP_001363885.1  ETS domain-containing protein Elk-4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC107837
    UniProtKB/Swiss-Prot
    A6H693, P41158
    Conserved Domains (2) summary
    smart00413
    Location:17 → 88
    ETS; erythroblast transformation specific domain
    PHA03247
    Location:170 → 349
    PHA03247; large tegument protein UL36; Provisional

  4. NM_001376957.1 → NP_001363886.1  ETS domain-containing protein Elk-4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC107837
    UniProtKB/Swiss-Prot
    A6H693, P41158
    Related
    ENSMUSP00000027696.4, ENSMUST00000027696.10
    Conserved Domains (2) summary
    smart00413
    Location:17 → 88
    ETS; erythroblast transformation specific domain
    PHA03247
    Location:170 → 349
    PHA03247; large tegument protein UL36; Provisional

  5. NM_001376958.1 → NP_001363887.1  ETS domain-containing protein Elk-4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC107837
    UniProtKB/Swiss-Prot
    A6H693, P41158
    Conserved Domains (2) summary
    smart00413
    Location:17 → 88
    ETS; erythroblast transformation specific domain
    PHA03247
    Location:170 → 349
    PHA03247; large tegument protein UL36; Provisional

  6. NM_001376959.1 → NP_001363888.1  ETS domain-containing protein Elk-4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC107837
    Conserved Domains (1) summary
    smart00413
    Location:17 → 69
    ETS; erythroblast transformation specific domain

  7. NM_007923.3 → NP_031949.2  ETS domain-containing protein Elk-4 isoform 1

    See identical proteins and their annotated locations for NP_031949.2

    Status: VALIDATED

    Source sequence(s)
    AC107837
    Consensus CDS
    CCDS35704.1
    UniProtKB/Swiss-Prot
    A6H693, P41158
    Related
    ENSMUSP00000083743.6, ENSMUST00000086556.12
    Conserved Domains (2) summary
    smart00413
    Location:17 → 88
    ETS; erythroblast transformation specific domain
    PHA03247
    Location:170 → 349
    PHA03247; large tegument protein UL36; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    131935129..131954186
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158973.1 → XP_036014866.1  ETS domain-containing protein Elk-4 isoform X1

    UniProtKB/Swiss-Prot
    A6H693, P41158
    Conserved Domains (2) summary
    smart00413
    Location:17 → 88
    ETS; erythroblast transformation specific domain
    PHA03247
    Location:170 → 349
    PHA03247; large tegument protein UL36; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P41158.2 GenPept UniProtKB/Swiss-Prot:P41158

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