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Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 13685, updated on 4-Jan-2025

Summary

Official Symbol
Eif4ebp1provided by MGI
Official Full Name
eukaryotic translation initiation factor 4E binding protein 1provided by MGI
Primary source
MGI:MGI:103267
See related
Ensembl:ENSMUSG00000031490 AllianceGenome:MGI:103267
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4e-bp1; PHAS-I
Summary
Enables eukaryotic initiation factor 4E binding activity. Involved in IRES-dependent translational initiation of linear mRNA. Acts upstream of or within cellular response to dexamethasone stimulus; insulin receptor signaling pathway; and negative regulation of translational initiation. Predicted to be located in cytosol. Predicted to be part of protein-containing complex. Predicted to be active in glutamatergic synapse and postsynaptic cytosol. Is expressed in several structures, including central nervous system; oocyte; pancreas tip epithelium; skeletal musculature; and thymus. Orthologous to human EIF4EBP1 (eukaryotic translation initiation factor 4E binding protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 161.1), mammary gland adult (RPKM 135.9) and 22 other tissues See more
Orthologs
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Genomic context

See Eif4ebp1 in Genome Data Viewer
Location:
8 A2; 8 15.95 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (27750355..27765684)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (27260327..27275656)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene adrenergic receptor, beta 3 Neighboring gene STARR-seq mESC enhancer starr_21024 Neighboring gene predicted gene 45470 Neighboring gene STARR-seq mESC enhancer starr_21025 Neighboring gene testis expressed gene 24 pseudogene Neighboring gene cyclin Q, pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables eukaryotic initiation factor 4E binding  
enables eukaryotic initiation factor 4E binding PubMed 
enables eukaryotic initiation factor 4E binding  
enables protein binding PubMed 
enables protein phosphatase 2A binding  
enables translation initiation factor binding  
enables translation repressor activity  
enables translation repressor activity  
enables translation repressor activity PubMed 
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle  
involved_in IRES-dependent translational initiation of linear mRNA PubMed 
involved_in TOR signaling  
involved_in TOR signaling  
acts_upstream_of_or_within cellular response to dexamethasone stimulus PubMed 
involved_in cellular response to hypoxia  
acts_upstream_of_or_within insulin receptor signaling pathway PubMed 
involved_in negative regulation of protein-containing complex assembly  
involved_in negative regulation of translation  
involved_in negative regulation of translational initiation  
acts_upstream_of_or_within negative regulation of translational initiation PubMed 
involved_in negative regulation of translational initiation  
involved_in positive regulation of mitotic cell cycle  
acts_upstream_of_or_within regulation of translational initiation PubMed 
involved_in response to amino acid starvation  
Component Evidence Code Pubs
is_active_in cytoplasm  
located_in cytoplasm PubMed 
located_in cytosol  
located_in cytosol  
is_active_in glutamatergic synapse  
located_in nucleus  
is_active_in postsynaptic cytosol  
part_of protein-containing complex  

General protein information

Preferred Names
eukaryotic translation initiation factor 4E-binding protein 1
Names
eIF4E-binding protein 1
phosphorylated heat- and acid-stable protein regulated by insulin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007918.3NP_031944.3  eukaryotic translation initiation factor 4E-binding protein 1

    See identical proteins and their annotated locations for NP_031944.3

    Status: VALIDATED

    Source sequence(s)
    AK013033, BE651550, BY318447
    Consensus CDS
    CCDS22214.1
    UniProtKB/Swiss-Prot
    Q3TDS8, Q60876, Q9CZ40
    UniProtKB/TrEMBL
    Q3TII9
    Related
    ENSMUSP00000033880.6, ENSMUST00000033880.7
    Conserved Domains (1) summary
    pfam05456
    Location:11117
    eIF_4EBP; Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    27750355..27765684
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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