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Eif3a eukaryotic translation initiation factor 3, subunit A [ Mus musculus (house mouse) ]

Gene ID: 13669, updated on 5-Mar-2024

Summary

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Official Symbol
Eif3aprovided by MGI
Official Full Name
eukaryotic translation initiation factor 3, subunit Aprovided by MGI
Primary source
MGI:MGI:95301
See related
Ensembl:ENSMUSG00000024991 AllianceGenome:MGI:95301
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Csma; Eif3; Eif3s10; mKIAA0139; A830012B05Rik
Summary
Contributes to translation initiation factor activity. Involved in formation of cytoplasmic translation initiation complex. Part of eukaryotic translation initiation factor 3 complex, eIF3m. Is active in postsynaptic density. Is expressed in central nervous system; retina; and testis. Orthologous to human EIF3A (eukaryotic translation initiation factor 3 subunit A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 81.9), liver E14 (RPKM 47.8) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 D3; 19 56.52 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (60749554..60779131, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (60761116..60790693, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34459 Neighboring gene predicted gene, 34406 Neighboring gene STARR-seq mESC enhancer starr_46601 Neighboring gene STARR-positive B cell enhancer ABC_E11044 Neighboring gene nanos C2HC-type zinc finger 1 Neighboring gene microRNA 3084-2 Neighboring gene small nucleolar RNA, H/ACA box 19 Neighboring gene STARR-positive B cell enhancer ABC_E7677 Neighboring gene STARR-positive B cell enhancer mm9_chr19:60887142-60887443 Neighboring gene 60S ribosomal protein L26-like Neighboring gene DENN domain containing 10 Neighboring gene sideroflexin 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Malignant transformation by the eukaryotic translation initiation factor 3 subunit p48 (eIF3e). Mayeur GL, et al. FEBS Lett, 2002 Mar 6. PMID 11904180
  2. The centrosomal protein centrosomin A and the nuclear protein centrosomin B derive from one gene by post-transcriptional processes involving RNA editing. Petzelt C, et al. J Cell Sci, 1997 Oct. PMID 9372446
  3. Murine cDNAs coding for the centrosomal antigen centrosomin A. Joswig G, et al. J Cell Sci, 1991 Jan. PMID 1829085
  4. Role of eIF3a in regulating cell cycle progression. Dong Z, et al. Exp Cell Res, 2009 Jul 1. PMID 19327350
  5. Role of eIF3a (eIF3 p170) in intestinal cell differentiation and its association with early development. Liu Z, et al. Differentiation, 2007 Sep. PMID 17381544

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. [IL-33 up-regulates eIF3a expression by activating NF-kappaB signaling pathway to mediate the proliferation and differentiation of mouse pulmonary myofibroblasts and aggravate pulmonary fibrosis].
    Title: [IL-33 up-regulates eIF3a expression by activating NF-κB signaling pathway to mediate the proliferation and differentiation of mouse pulmonary myofibroblasts and aggravate pulmonary fibrosis].
  2. The pleiotropic mouse phenotype extra-toes spotting is caused by translation initiation factor Eif3c mutations.
    Title: The pleiotropic mouse phenotype extra-toes spotting is caused by translation initiation factor Eif3c mutations and is associated with disrupted sonic hedgehog signaling.
  3. May play some roles in development and differentiation; decreased eIF3a expression may be a pre-requisite of intestinal epithelial cell differentiation.
    Title: Role of eIF3a (eIF3 p170) in intestinal cell differentiation and its association with early development.
  4. eIF3a expression oscillated with cell cycle and peaked in S phase. Reducing eIF3a expression also reduced cell proliferation rate by elongating cell cycle but did not change the cell cycle distribution.
    Title: Role of eIF3a in regulating cell cycle progression.
  5. Stable expression of a truncated eIF3e in NIH 3T3 cells causes malignant transformation
    Title: Malignant transformation by the eukaryotic translation initiation factor 3 subunit p48 (eIF3e).
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to translation initiation factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to translation initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in IRES-dependent viral translational initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in formation of cytoplasmic translation initiation complex IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in formation of cytoplasmic translation initiation complex IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in formation of cytoplasmic translation initiation complex ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation reinitiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within translational initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in viral translational termination-reinitiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of eukaryotic translation initiation factor 3 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of eukaryotic translation initiation factor 3 complex ISO
Inferred from Sequence Orthology
more info
  
part_of eukaryotic translation initiation factor 3 complex, eIF3e IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 3 complex, eIF3m IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 3 complex, eIF3m IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
  
part_of multi-eIF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density EXP
Inferred from Experiment
more info
 PubMed 
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
eukaryotic translation initiation factor 3 subunit A
Names
EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 10 (EIF-3 THETA) (EIF3 P167) (EIF3 P180) (EIF3 P185) (P162 PROTEIN) (CENTROSOMIN)
centrosomin
eIF-3-theta
eIF3 p167
eIF3 p180
eIF3 p185
eukaryotic translation initiation factor 3, subunit 10 (theta)
p162

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010123.3 → NP_034253.3  eukaryotic translation initiation factor 3 subunit A

    See identical proteins and their annotated locations for NP_034253.3

    Status: VALIDATED

    Source sequence(s)
    AC163019, AK013070, AK145132, AK162784, U14172
    Consensus CDS
    CCDS38035.1
    UniProtKB/Swiss-Prot
    E9QQ50, P23116, Q60697, Q62162
    Related
    ENSMUSP00000025955.7, ENSMUST00000025955.8
    Conserved Domains (5) summary
    smart00753
    Location:426 → 498
    PAM; PCI/PINT associated module
    pfam05750
    Location:882 → 1111
    Rubella_Capsid; Rubella capsid protein
    cd16269
    Location:650 → 661
    GBP_C; coiled coil [structural motif]
    cl19219
    Location:643 → 737
    DUF342; Protein of unknown function (DUF342)
    cl20817
    Location:566 → 685
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    60749554..60779131 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23116.5 GenPept UniProtKB/Swiss-Prot:P23116

Gene LinkOut

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