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Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 [ Mus musculus (house mouse) ]

Gene ID: 13666, updated on 4-Jan-2025

Summary

Official Symbol
Eif2ak3provided by MGI
Official Full Name
eukaryotic translation initiation factor 2 alpha kinase 3provided by MGI
Primary source
MGI:MGI:1341830
See related
Ensembl:ENSMUSG00000031668 AllianceGenome:MGI:1341830
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pek; Perk
Summary
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in a similar gene in human are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015]
Expression
Ubiquitous expression in placenta adult (RPKM 10.8), colon adult (RPKM 7.9) and 28 other tissues See more
Orthologs
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Genomic context

See Eif2ak3 in Genome Data Viewer
Location:
6 C1; 6 32.09 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (70821468..70882225)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (70844484..70905241)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16238 Neighboring gene ribose 5-phosphate isomerase A Neighboring gene STARR-positive B cell enhancer ABC_E6436 Neighboring gene STARR-seq mESC enhancer starr_16241 Neighboring gene STARR-positive B cell enhancer mm9_chr6:70761912-70762213 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:70764223-70764410 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:70765584-70765767 Neighboring gene predicted gene, 30331 Neighboring gene STARR-seq mESC enhancer starr_16242 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:70779525-70779708 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:70812737-70812920 Neighboring gene predicted gene, 23346 Neighboring gene STARR-positive B cell enhancer ABC_E6438 Neighboring gene STARR-positive B cell enhancer ABC_E4832 Neighboring gene sperm microtubule inner protein 9 Neighboring gene forkhead box I3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Items 1 - 25 of 43
Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity  
enables AMP-activated protein kinase activity  
enables ATP binding  
enables DNA-dependent protein kinase activity  
enables Hsp90 protein binding  
enables Rho-dependent protein serine/threonine kinase activity  
enables enzyme binding  
enables eukaryotic initiation factor eIF2 binding PubMed 
enables eukaryotic translation initiation factor 2alpha kinase activity  
enables eukaryotic translation initiation factor 2alpha kinase activity PubMed 
enables eukaryotic translation initiation factor 2alpha kinase activity PubMed 
enables eukaryotic translation initiation factor 2alpha kinase activity PubMed 
enables eukaryotic translation initiation factor 2alpha kinase activity  
enables eukaryotic translation initiation factor 2alpha kinase activity  
enables histone H2AS1 kinase activity  
enables histone H2AS121 kinase activity  
enables histone H2AT120 kinase activity  
enables histone H2AXS139 kinase activity  
enables histone H2AXY142 kinase activity  
enables histone H2BS14 kinase activity  
enables histone H2BS36 kinase activity  
enables histone H3S10 kinase activity  
enables histone H3S28 kinase activity  
enables histone H3S57 kinase activity  
enables histone H3T11 kinase activity  
enables histone H3T3 kinase activity  
enables histone H3T45 kinase activity  
enables histone H3T6 kinase activity  
enables histone H3Y41 kinase activity  
enables histone H4S1 kinase activity  
enables identical protein binding PubMed 
enables identical protein binding  
enables misfolded protein binding PubMed 
enables protein binding PubMed 
enables protein kinase activity PubMed 
enables protein kinase activity PubMed 
enables protein phosphatase binding  
enables protein serine kinase activity  
enables protein serine/threonine kinase activity PubMed 
enables protein serine/threonine kinase activity  
enables protein serine/threonine kinase activity  
enables protein tyrosine kinase activity PubMed 
enables ribosomal protein S6 kinase activity  
Items 1 - 25 of 43
Items 1 - 25 of 81
Process Evidence Code Pubs
involved_in ER overload response  
involved_in ER overload response  
involved_in ERAD pathway PubMed 
involved_in PERK-mediated unfolded protein response PubMed 
involved_in PERK-mediated unfolded protein response PubMed 
acts_upstream_of_or_within SREBP signaling pathway PubMed 
involved_in angiogenesis  
acts_upstream_of_or_within bone mineralization PubMed 
acts_upstream_of_or_within calcium-mediated signaling PubMed 
involved_in cellular response to amino acid starvation  
involved_in cellular response to amino acid starvation  
involved_in cellular response to cold  
involved_in cellular response to cold  
involved_in cellular response to glucose starvation PubMed 
involved_in cellular response to glucose starvation  
acts_upstream_of_or_within chondrocyte development PubMed 
involved_in chromatin remodeling  
involved_in eiF2alpha phosphorylation in response to endoplasmic reticulum stress PubMed 
involved_in eiF2alpha phosphorylation in response to endoplasmic reticulum stress  
involved_in eiF2alpha phosphorylation in response to endoplasmic reticulum stress  
involved_in endocrine pancreas development  
involved_in endocrine pancreas development  
acts_upstream_of_or_within endoplasmic reticulum organization PubMed 
acts_upstream_of_or_within endoplasmic reticulum unfolded protein response PubMed 
acts_upstream_of_or_within endoplasmic reticulum unfolded protein response PubMed 
involved_in endoplasmic reticulum unfolded protein response  
involved_in endoplasmic reticulum unfolded protein response  
involved_in endoplasmic reticulum unfolded protein response PubMed 
acts_upstream_of_or_within fat cell differentiation PubMed 
acts_upstream_of_or_within insulin-like growth factor receptor signaling pathway PubMed 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress PubMed 
acts_upstream_of_or_within lactation PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process PubMed 
acts_upstream_of_or_within negative regulation of gene expression PubMed 
acts_upstream_of_or_within negative regulation of myelination PubMed 
involved_in negative regulation of translation  
acts_upstream_of_or_within negative regulation of translation PubMed 
acts_upstream_of_or_within negative regulation of translation PubMed 
acts_upstream_of_or_within negative regulation of translation PubMed 
involved_in negative regulation of translation PubMed 
involved_in negative regulation of translation PubMed 
involved_in negative regulation of translation in response to endoplasmic reticulum stress PubMed 
involved_in negative regulation of translation in response to stress  
involved_in ossification  
involved_in ossification  
acts_upstream_of_or_within pancreas development PubMed 
involved_in peptidyl-serine phosphorylation PubMed 
involved_in positive regulation of ERAD pathway PubMed 
acts_upstream_of_or_within positive regulation of cysteine-type endopeptidase activity PubMed 
acts_upstream_of_or_within positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway PubMed 
involved_in positive regulation of gene expression PubMed 
involved_in positive regulation of gene expression  
involved_in positive regulation of glutathione biosynthetic process PubMed 
acts_upstream_of_or_within positive regulation of protein binding PubMed 
involved_in positive regulation of protein localization to nucleus PubMed 
acts_upstream_of_or_within positive regulation of signal transduction PubMed 
involved_in positive regulation of transcription by RNA polymerase I PubMed 
involved_in positive regulation of transcription by RNA polymerase I  
involved_in positive regulation of vascular endothelial growth factor production PubMed 
involved_in positive regulation of vascular endothelial growth factor production  
acts_upstream_of_or_within protein autophosphorylation PubMed 
involved_in protein autophosphorylation PubMed 
acts_upstream_of_or_within protein autophosphorylation PubMed 
involved_in protein autophosphorylation  
involved_in protein autophosphorylation  
acts_upstream_of_or_within protein phosphorylation PubMed 
involved_in protein phosphorylation PubMed 
acts_upstream_of_or_within protein phosphorylation PubMed 
involved_in protein phosphorylation PubMed 
involved_in regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation PubMed 
involved_in regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  
acts_upstream_of_or_within regulation of fatty acid metabolic process PubMed 
involved_in regulation of translational initiation  
involved_in regulation of translational initiation PubMed 
involved_in regulation of translational initiation by eIF2 alpha phosphorylation PubMed 
involved_in regulation of translational initiation by eIF2 alpha phosphorylation PubMed 
involved_in response to endoplasmic reticulum stress PubMed 
involved_in response to endoplasmic reticulum stress PubMed 
involved_in response to endoplasmic reticulum stress  
acts_upstream_of_or_within skeletal system development PubMed 
acts_upstream_of_or_within translation PubMed 
Items 1 - 25 of 81
Component Evidence Code Pubs
is_active_in cytoplasm  
located_in cytoplasm PubMed 
located_in endoplasmic reticulum PubMed 
located_in endoplasmic reticulum membrane PubMed 
located_in endoplasmic reticulum membrane  
located_in endoplasmic reticulum quality control compartment PubMed 
is_active_in nucleus  
located_in perinuclear region of cytoplasm  

General protein information

Preferred Names
eukaryotic translation initiation factor 2-alpha kinase 3
Names
PRKR-like endoplasmic reticulum kinase
pancreatic eIF2-alpha kinase
protein tyrosine kinase EIF2AK3
NP_001300847.1
NP_034251.2
XP_006505564.1
XP_011239504.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313918.1NP_001300847.1  eukaryotic translation initiation factor 2-alpha kinase 3 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks multiple alternate 3' exons and uses an alternate 3' terminal exon, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AC156398, AK010397
    Consensus CDS
    CCDS85063.1
    UniProtKB/TrEMBL
    A0A0R4J1Y1
    Related
    ENSMUSP00000123759.2, ENSMUST00000162950.2
    Conserved Domains (1) summary
    cl14874
    Location:100127
    Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins
  2. NM_010121.3NP_034251.2  eukaryotic translation initiation factor 2-alpha kinase 3 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC155842, BC054809, BP762515
    Consensus CDS
    CCDS20223.1
    UniProtKB/Swiss-Prot
    Q9CTK8, Q9CWT5, Q9Z2B5
    UniProtKB/TrEMBL
    E9QQ30, Q7TQC8
    Related
    ENSMUSP00000034093.9, ENSMUST00000034093.15
    Conserved Domains (4) summary
    cd09768
    Location:100416
    Luminal_EIF2AK3; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3
    smart00220
    Location:8791071
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14048
    Location:8741073
    STKc_EIF2AK3_PERK; Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3 or PKR-like Endoplasmic Reticulum Kinase
    cl21453
    Location:583671
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    70821468..70882225
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241202.3XP_011239504.1  eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1

    UniProtKB/Swiss-Prot
    Q9CTK8, Q9CWT5, Q9Z2B5
    UniProtKB/TrEMBL
    Q7TQC8
    Conserved Domains (3) summary
    cd09768
    Location:100416
    Luminal_EIF2AK3; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3
    cd14048
    Location:8731072
    STKc_EIF2AK3_PERK; Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3 or PKR-like Endoplasmic Reticulum Kinase
    cl21453
    Location:582670
    PKc_like; Protein Kinases, catalytic domain
  2. XM_006505501.2XP_006505564.1  eukaryotic translation initiation factor 2-alpha kinase 3 isoform X2

    Conserved Domains (3) summary
    cd14048
    Location:637836
    STKc_EIF2AK3_PERK; Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3 or PKR-like Endoplasmic Reticulum Kinase
    cl14874
    Location:28179
    Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins
    cl21453
    Location:346434
    PKc_like; Protein Kinases, catalytic domain
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