Egr2 early growth response 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Egr2provided by MGI
Official Full Name: early growth response 2provided by MGI
Primary source: MGI:MGI:95296
See related: Ensembl:ENSMUSG00000037868 AllianceGenome:MGI:95296
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Egr-2; Zfp-6; Krox20; NGF1-B; Zfp-25; Krox-20
Summary: Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and SUMO ligase activity. Involved in several processes, including nervous system development; positive regulation of myelination; and protein sumoylation. Acts upstream of or within several processes, including nervous system development; regulation of ossification; and skeletal muscle cell differentiation. Located in cytoplasm and nucleus. Is expressed in several structures, including genitourinary system; head mesenchyme derived from neural crest; nervous system; neural ectoderm; and vibrissa. Used to study Charcot-Marie-Tooth disease type 4E. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 1D; Charcot-Marie-Tooth disease type 3; Charcot-Marie-Tooth disease type 4E; and motor peripheral neuropathy. Orthologous to human EGR2 (early growth response 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in genital fat pad adult (RPKM 22.3), thymus adult (RPKM 4.2) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B5.1; 10 34.96 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (67370334..67383354)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (67534469..67542188)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Egr2 Deletion in Autoimmune-Prone C57BL6/lpr Mice Suppresses the Expression of Methylation-Sensitive Dlk1-Dio3 Cluster MicroRNAs.
Title: Egr2 Deletion in Autoimmune-Prone C57BL6/lpr Mice Suppresses the Expression of Methylation-Sensitive Dlk1-Dio3 Cluster MicroRNAs.
EGR2 drives TH17 cell pathogenicity in autoimmune neuroinflammation.
Title: EGR2 drives T(H)17 cell pathogenicity in autoimmune neuroinflammation.
Transcription factor EGR2 controls homing and pathogenicity of TH17 cells in the central nervous system.
Title: Transcription factor EGR2 controls homing and pathogenicity of T(H)17 cells in the central nervous system.
Egr2 and 3 maintain anti-tumour responses of exhausted tumour infiltrating CD8 + T cells.
Title: Egr2 and 3 maintain anti-tumour responses of exhausted tumour infiltrating CD8 + T cells.
Early growth response 2 in the mPFC regulates mouse social and cooperative behaviors.
Title: Early growth response 2 in the mPFC regulates mouse social and cooperative behaviors.
Egr2 contributes to age-dependent vulnerability to sevoflurane-induced cognitive deficits in mice.
Title: Egr2 contributes to age-dependent vulnerability to sevoflurane-induced cognitive deficits in mice.
BMSC-Derived Exosomal Egr2 Ameliorates Ischemic Stroke by Directly Upregulating SIRT6 to Suppress Notch Signaling.
Title: BMSC-Derived Exosomal Egr2 Ameliorates Ischemic Stroke by Directly Upregulating SIRT6 to Suppress Notch Signaling.
EGR2 is a hub-gene in myocardial infarction and aggravates inflammation and apoptosis in hypoxia-induced cardiomyocytes.
Title: EGR2 is a hub-gene in myocardial infarction and aggravates inflammation and apoptosis in hypoxia-induced cardiomyocytes.
Susceptibility to kidney fibrosis in mice is associated with early growth response-2 protein and tissue inhibitor of metalloproteinase-1 expression.
Title: Susceptibility to kidney fibrosis in mice is associated with early growth response-2 protein and tissue inhibitor of metalloproteinase-1 expression.
EGR2 Deletion Suppresses Anti-DsDNA Autoantibody and IL-17 Production in Autoimmune-Prone B6/lpr Mice: A Differential Immune Regulatory Role of EGR2 in B6/lpr Versus Normal B6 Mice.
Title: EGR2 Deletion Suppresses Anti-DsDNA Autoantibody and IL-17 Production in Autoimmune-Prone B6/lpr Mice: A Differential Immune Regulatory Role of EGR2 in B6/lpr Versus Normal B6 Mice.

Submit: New GeneRIF Correction See all GeneRIFs (110)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (13) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Egr2 (e-PCR), detects polymorphism
- UniSTS:547589

PMC85614P2 (e-PCR)
- UniSTS:273477

Egr2 (e-PCR), detects polymorphism
- UniSTS:238159

Egr2 (e-PCR), detects polymorphism
- UniSTS:496733

X06746 (e-PCR)
- UniSTS:125792

Egr2 (e-PCR), detects polymorphism
- UniSTS:142974

Egr2 (e-PCR), detects polymorphism
- UniSTS:470667

X06746 (e-PCR)
- UniSTS:159986

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables HMG box domain binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables SUMO ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Schwann cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Schwann cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in aorta development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within brain segmentation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to organic substance	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within facial nerve structural organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in facial nerve structural organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_negative_effect gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within motor neuron axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within myelination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of Schwann cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of myelination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein export from nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in protein sumoylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of ossification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to insulin	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within rhombomere 3 development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within rhombomere 3 formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rhombomere 3 structural organization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within rhombomere 5 formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rhombomere 5 structural organization	IDA Inferred from Direct Assay more info	PubMed
involved_in rhombomere 5 structural organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within rhythmic behavior	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within rhythmic behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in skeletal muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: E3 SUMO-protein ligase EGR2

Names: E3 SUMO-protein transferase ERG2; early growth response protein 2; zinc finger protein Krox-20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347458.1 → NP_001334387.1 E3 SUMO-protein ligase EGR2 isoform 2

Status: VALIDATED

Source sequence(s)

AK155585, BP753840, BY209001

Consensus CDS

CCDS83706.1

UniProtKB/TrEMBL

D3Z3K7

Conserved Domains (4) summary

COG5048
Location:315 → 371

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:289 → 311

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:287 → 311

zf-C2H2; Zinc finger, C2H2 type

pfam11928
Location:44 → 116

DUF3446; Domain of unknown function (DUF3446)
NM_001373983.1 → NP_001360912.1 E3 SUMO-protein ligase EGR2 isoform 3

Status: VALIDATED

Source sequence(s)

AC153379

UniProtKB/TrEMBL

D3Z3K7

Conserved Domains (4) summary

COG5048
Location:378 → 434

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:352 → 374

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:350 → 374

zf-C2H2; Zinc finger, C2H2 type

pfam11928
Location:107 → 179

DUF3446; Domain of unknown function (DUF3446)
NM_001373985.1 → NP_001360914.1 E3 SUMO-protein ligase EGR2 isoform 2

Status: VALIDATED

Source sequence(s)

AC153379

Consensus CDS

CCDS83706.1

UniProtKB/TrEMBL

D3Z3K7

Conserved Domains (4) summary

COG5048
Location:315 → 371

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:289 → 311

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:287 → 311

zf-C2H2; Zinc finger, C2H2 type

pfam11928
Location:44 → 116

DUF3446; Domain of unknown function (DUF3446)
NM_001373986.1 → NP_001360915.1 E3 SUMO-protein ligase EGR2 isoform 2

Status: VALIDATED

Source sequence(s)

AC153379

Consensus CDS

CCDS83706.1

UniProtKB/TrEMBL

D3Z3K7

Conserved Domains (4) summary

COG5048
Location:315 → 371

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:289 → 311

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:287 → 311

zf-C2H2; Zinc finger, C2H2 type

pfam11928
Location:44 → 116

DUF3446; Domain of unknown function (DUF3446)
NM_001373987.1 → NP_001360916.1 E3 SUMO-protein ligase EGR2 isoform 2

Status: VALIDATED

Source sequence(s)

AC153379

Consensus CDS

CCDS83706.1

UniProtKB/TrEMBL

D3Z3K7

Related

ENSMUSP00000101078.3, ENSMUST00000105438.9

Conserved Domains (4) summary

COG5048
Location:315 → 371

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:289 → 311

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:287 → 311

zf-C2H2; Zinc finger, C2H2 type

pfam11928
Location:44 → 116

DUF3446; Domain of unknown function (DUF3446)
NM_010118.3 → NP_034248.2 E3 SUMO-protein ligase EGR2 isoform 1

See identical proteins and their annotated locations for NP_034248.2

Status: VALIDATED

Source sequence(s)

AK155585, BY742929, X06746

Consensus CDS

CCDS35927.2

UniProtKB/Swiss-Prot

P08152

UniProtKB/TrEMBL

D3Z3K7, Q3U207

Related

ENSMUSP00000041053.8, ENSMUST00000048289.14

Conserved Domains (5) summary

COG5048
Location:365 → 421

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:339 → 361

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:337 → 361

zf-C2H2; Zinc finger, C2H2 type

pfam11928
Location:94 → 166

DUF3446; Domain of unknown function (DUF3446)

pfam13465
Location:381 → 406

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

67370334..67383354

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030244870.2 → XP_030100730.1 E3 SUMO-protein ligase EGR2 isoform X1

UniProtKB/TrEMBL

D3Z3K7

Conserved Domains (4) summary

COG5048
Location:378 → 434

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:352 → 374

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:350 → 374

zf-C2H2; Zinc finger, C2H2 type

pfam11928
Location:107 → 179

DUF3446; Domain of unknown function (DUF3446)