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Eef2 eukaryotic translation elongation factor 2 [ Mus musculus (house mouse) ]

Gene ID: 13629, updated on 23-Mar-2024

Summary

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Official Symbol
Eef2provided by MGI
Official Full Name
eukaryotic translation elongation factor 2provided by MGI
Primary source
MGI:MGI:95288
See related
Ensembl:ENSMUSG00000034994 AllianceGenome:MGI:95288
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ef-2
Summary
Enables GTPase activity. Acts upstream of or within hematopoietic progenitor cell differentiation and translational elongation. Located in cytoplasm. Part of polysome. Is active in synapse. Is expressed in brain. Human ortholog(s) of this gene implicated in glaucoma and spinocerebellar ataxia type 26. Orthologous to human EEF2 (eukaryotic translation elongation factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 1248.0), colon adult (RPKM 810.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Eef2 in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (81012465..81018343)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81176631..81182509)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E463 Neighboring gene STARR-positive B cell enhancer ABC_E8349 Neighboring gene STARR-seq mESC enhancer starr_27318 Neighboring gene zinc finger and BTB domain containing 7a Neighboring gene protein inhibitor of activated STAT 4 Neighboring gene STARR-positive B cell enhancer ABC_E901 Neighboring gene STARR-positive B cell enhancer ABC_E8866 Neighboring gene STARR-positive B cell enhancer ABC_E3901 Neighboring gene STARR-positive B cell enhancer ABC_E5157 Neighboring gene STARR-positive B cell enhancer ABC_E2329 Neighboring gene small nucleolar RNA, C/D box 37 Neighboring gene death-associated protein kinase 3 Neighboring gene ataxia, cerebellar, Cayman type, opposite strand Neighboring gene nicotinamide riboside kinase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. eEF2 in the prefrontal cortex promotes excitatory synaptic transmission and social novelty behavior. Ma X, et al. EMBO Rep, 2022 Oct 6. PMID 35993189, Free PMC Article
  2. The phosphorylation status of eukaryotic elongation factor-2 indicates neural activity in the brain. Yoon SH, et al. Mol Brain, 2021 Sep 15. PMID 34526091, Free PMC Article
  3. Translation elongation factor 2 depletion by siRNA in mouse liver leads to mTOR-independent translational upregulation of ribosomal protein genes. Gerashchenko MV, et al. Sci Rep, 2020 Sep 23. PMID 32968084, Free PMC Article
  4. Methylation of eukaryotic elongation factor 2 induced by basic fibroblast growth factor via mitogen-activated protein kinase. Jung GA, et al. Exp Mol Med, 2011 Oct 31. PMID 21778808, Free PMC Article
  5. Identification of a 100-kDa phosphoprotein in developing murine embryos as elongation factor 2. Brown TL, et al. Arch Biochem Biophys, 1994 Feb 15. PMID 8117099

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interaction of lncRNA Gm2044 and EEF2 promotes estradiol synthesis in ovarian follicular granulosa cells.
    Title: Interaction of lncRNA Gm2044 and EEF2 promotes estradiol synthesis in ovarian follicular granulosa cells.
  2. eEF2 in the prefrontal cortex promotes excitatory synaptic transmission and social novelty behavior.
    Title: eEF2 in the prefrontal cortex promotes excitatory synaptic transmission and social novelty behavior.
  3. Amyloid beta induces Fmr1-dependent translational suppression and hyposynchrony of neural activity via phosphorylation of eIF2alpha and eEF2.
    Title: Amyloid beta induces Fmr1-dependent translational suppression and hyposynchrony of neural activity via phosphorylation of eIF2α and eEF2.
  4. The phosphorylation status of eukaryotic elongation factor-2 indicates neural activity in the brain.
    Title: The phosphorylation status of eukaryotic elongation factor-2 indicates neural activity in the brain.
  5. Fluoxetine regulates eEF2 activity (phosphorylation) via HDAC1 inhibitory mechanism in an LPS-induced mouse model of depression.
    Title: Fluoxetine regulates eEF2 activity (phosphorylation) via HDAC1 inhibitory mechanism in an LPS-induced mouse model of depression.
  6. Repression of eEF2 kinase improves deficits in novel object recognition memory in aged mice.
    Title: Repression of eEF2 kinase improves deficits in novel object recognition memory in aged mice.
  7. PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation.
    Title: PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation.
  8. Translation elongation factor 2 depletion by siRNA in mouse liver leads to mTOR-independent translational upregulation of ribosomal protein genes.
    Title: Translation elongation factor 2 depletion by siRNA in mouse liver leads to mTOR-independent translational upregulation of ribosomal protein genes.
  9. Myostatin inhibits eEF2K-eEF2 by regulating AMPK to suppress protein synthesis.
    Title: Myostatin inhibits eEF2K-eEF2 by regulating AMPK to suppress protein synthesis.
  10. IL-6 induces the activation of the Stat3 signaling and promotes the downmodulation of the p90RSK/eEF2 and mTOR/p70S6K axes, while it does not affect the activation of AKT.
    Title: IL-6 impairs myogenic differentiation by downmodulation of p90RSK/eEF2 and mTOR/p70S6K axes, without affecting AKT activity.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC98463

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 5S rRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables p53 binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribosome binding ISO
Inferred from Sequence Orthology
more info
  
enables translation elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation elongation factor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cytoplasmic translation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of translation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation at postsynapse ISO
Inferred from Sequence Orthology
more info
  
involved_in translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within translational elongation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in translational elongation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in aggresome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
NOT located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ribosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
elongation factor 2
NP_031933.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007907.3 → NP_031933.1  elongation factor 2

    See identical proteins and their annotated locations for NP_031933.1

    Status: VALIDATED

    Source sequence(s)
    AC155932
    Consensus CDS
    CCDS35993.1
    UniProtKB/Swiss-Prot
    P58252, Q544E4
    UniProtKB/TrEMBL
    Q3TJZ1, Q3TK17, Q3TX47, Q3UDC8
    Related
    ENSMUSP00000046101.10, ENSMUST00000047864.11
    Conserved Domains (6) summary
    cd01885
    Location:20 → 233
    EF2; Elongation Factor 2 (EF2) in archaea and eukarya
    cd01681
    Location:574 → 746
    aeEF2_snRNP_like_IV; This family represents domain IV of archaeal and eukaryotic elongation factor 2 (aeEF-2) and of an evolutionarily conserved U5 snRNP-specific protein. U5 snRNP is a GTP-binding factor closely related to the ribosomal translocase EF-2. In complex with GTP, ...
    cd04096
    Location:742 → 821
    eEF2_snRNP_like_C; eEF2_snRNP_like_C: this family represents a C-terminal domain of eukaryotic elongation factor 2 (eEF-2) and a homologous domain of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast counterpart ...
    PTZ00416
    Location:1 → 858
    PTZ00416; elongation factor 2; Provisional
    cd03700
    Location:394 → 488
    EF2_snRNP_like_II; Domain II of elongation factor 2 and C-terminal domain of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein
    cd16261
    Location:503 → 574
    EF2_snRNP_III; Domain III of Elongation Factor 2 (EF2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    81012465..81018343
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P58252.2 GenPept UniProtKB/Swiss-Prot:P58252

Gene LinkOut

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