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Dmc1 DNA meiotic recombinase 1 [ Mus musculus (house mouse) ]

Gene ID: 13404, updated on 5-Mar-2024

Summary

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Official Symbol
Dmc1provided by MGI
Official Full Name
DNA meiotic recombinase 1provided by MGI
Primary source
MGI:MGI:105393
See related
Ensembl:ENSMUSG00000022429 AllianceGenome:MGI:105393
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
sgdp; Dmc1h; Lim15; Mei11
Summary
This gene encodes a member of the superfamily of recombinases (also called DNA strand-exchange proteins). Recombinases are important for repairing double-strand DNA breaks during mitosis and meiosis. This protein, which is evolutionarily conserved, is reported to be essential for meiotic homologous recombination and may thus play an important role in generating diversity of genetic information. In mouse, deficiency of this gene causes infertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Expression
Biased expression in limb E14.5 (RPKM 2.8), testis adult (RPKM 2.6) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Dmc1 in Genome Data Viewer
Location:
15 E1; 15 37.79 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (79445698..79489362, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79561497..79605159, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 4 Neighboring gene STARR-seq mESC enhancer starr_39188 Neighboring gene KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 Neighboring gene STARR-seq mESC enhancer starr_39189 Neighboring gene DEAD box helicase 17 Neighboring gene family with sequence similarity 227, member A Neighboring gene STARR-seq mESC enhancer starr_39191 Neighboring gene STARR-seq mESC enhancer starr_39193 Neighboring gene predicted gene, 30877 Neighboring gene chibby family member 1, beta catenin antagonist

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Gene expression profiling of mouse bladder inflammatory responses to LPS, substance P, and antigen-stimulation. Saban MR, et al. Am J Pathol, 2002 Jun. PMID 12057914, Free PMC Article
  2. The mouse RecA-like gene Dmc1 is required for homologous chromosome synapsis during meiosis. Yoshida K, et al. Mol Cell, 1998 Apr. PMID 9660954
  3. Meiotic prophase arrest with failure of chromosome synapsis in mice deficient for Dmc1, a germline-specific RecA homolog. Pittman DL, et al. Mol Cell, 1998 Apr. PMID 9660953
  4. Characterization of a mouse recA-like gene specifically expressed in testis. Sato S, et al. DNA Res, 1995 Jun 30. PMID 8581742
  5. A putative human infertility allele of the meiotic recombinase DMC1 does not affect fertility in mice. Tran TN, et al. Hum Mol Genet, 2018 Nov 15. PMID 30085085, Free PMC Article

See all (151) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in pre-meiotic DNA replication and meiotic recombination.
    Title: FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in pre-meiotic DNA replication and meiotic recombination.
  2. The FLIP-FIGNL1 complex regulates the dissociation of RAD51/DMC1 in homologous recombination and replication fork restart.
    Title: The FLIP-FIGNL1 complex regulates the dissociation of RAD51/DMC1 in homologous recombination and replication fork restart.
  3. The Configuration of RPA, RAD51, and DMC1 Binding in Meiosis Reveals the Nature of Critical Recombination Intermediates.
    Title: The Configuration of RPA, RAD51, and DMC1 Binding in Meiosis Reveals the Nature of Critical Recombination Intermediates.
  4. Super-resolution imaging of RAD51 and DMC1 in DNA repair foci reveals dynamic distribution patterns in meiotic prophase.
    Title: Super-resolution imaging of RAD51 and DMC1 in DNA repair foci reveals dynamic distribution patterns in meiotic prophase.
  5. In this study, we created a mouse model of a putative infertility allele, DMC1M200V. DMC1 encodes a RecA homolog essential for meiotic recombination and fertility in mice..we found that Dmc1M200V/M200V male and female mice are fully fertile and do not exhibit any gonadal abnormalities
    Title: A putative human infertility allele of the meiotic recombinase DMC1 does not affect fertility in mice.
  6. we observed the occurrence of synaptonemal complex bridges between bivalents, most likely representing chromosome translocation events that may involve DMC1, RAD51 or 53BP1.
    Title: Transition from a meiotic to a somatic-like DNA damage response during the pachytene stage in mouse meiosis.
  7. The DMC1 was highly variable from cell to cell, whereas foci of the crossover marker MLH1 showed little variability.
    Title: Homeostatic control of recombination is implemented progressively in mouse meiosis.
  8. RAD51AP1 foci colocalize with a subset of DMC1 foci in spermatocytes.
    Title: Molecular basis for enhancement of the meiotic DMC1 recombinase by RAD51 associated protein 1 (RAD51AP1).
  9. Dmc1(Mei11) exposes a sex difference in recombination in that a significant portion of female oocytes can compensate for DMC1 deficiency to undergo crossing-over and complete gametogenesis.
    Title: A dominant, recombination-defective allele of Dmc1 causing male-specific sterility.
  10. Mei1 can be positioned upstream of Dmc1 in the genetic pathway that operates during mammalian meiosis
    Title: Mei1 is epistatic to Dmc1 during mouse meiosis.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC151144

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent DNA damage sensor activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent activity, acting on DNA IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP-dependent activity, acting on DNA ISO
Inferred from Sequence Orthology
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA strand exchange activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA strand exchange activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA recombinase assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA strand invasion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome organization involved in meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair involved in meiotic recombination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within gamete generation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within homologous chromosome pairing at meiosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within male meiosis I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within oocyte maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within oogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within oogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within ovarian follicle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in reciprocal meiotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in reciprocal meiotic recombination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in reciprocal meiotic recombination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatid development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome, telomeric region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in condensed nuclear chromosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lateral element IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in site of double-strand break IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
meiotic recombination protein DMC1/LIM15 homolog
Names
DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination
disrupted meiotic cDNA 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278226.1 → NP_001265155.1  meiotic recombination protein DMC1/LIM15 homolog isoform 2

    See identical proteins and their annotated locations for NP_001265155.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two alternate exons in the coding region compared to variant 1. The resulting protein (isoform 2) lacks an internal portion and is shorter, compared to isoform 1.
    Source sequence(s)
    AK076777, AK169570, AV451479
    Consensus CDS
    CCDS88806.1
    UniProtKB/TrEMBL
    Q8C610
    Related
    ENSMUSP00000155228.2, ENSMUST00000229408.2
    Conserved Domains (3) summary
    TIGR02238
    Location:24 → 283
    recomb_DMC1; meiotic recombinase Dmc1
    cd01123
    Location:101 → 281
    Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
    pfam14520
    Location:25 → 79
    HHH_5; Helix-hairpin-helix domain

  2. NM_010059.3 → NP_034189.1  meiotic recombination protein DMC1/LIM15 homolog isoform 1

    See identical proteins and their annotated locations for NP_034189.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK169570, AV451479, BC116767
    Consensus CDS
    CCDS27644.1
    UniProtKB/Swiss-Prot
    Q61880
    UniProtKB/TrEMBL
    Q14AN8
    Related
    ENSMUSP00000023065.7, ENSMUST00000023065.8
    Conserved Domains (3) summary
    TIGR02238
    Location:24 → 338
    recomb_DMC1; meiotic recombinase Dmc1
    cd01123
    Location:101 → 336
    Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
    pfam14520
    Location:25 → 79
    HHH_5; Helix-hairpin-helix domain

RNA

  1. NR_103477.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks five alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK169570, AV451479
    Related
    ENSMUST00000230011.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    79445698..79489362 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520407.4 → XP_006520470.1  meiotic recombination protein DMC1/LIM15 homolog isoform X1

    Conserved Domains (1) summary
    TIGR02238
    Location:24 → 296
    recomb_DMC1; meiotic recombinase Dmc1

  2. XM_006520408.4 → XP_006520471.1  meiotic recombination protein DMC1/LIM15 homolog isoform X2

    Conserved Domains (1) summary
    TIGR02238
    Location:24 → 282
    recomb_DMC1; meiotic recombinase Dmc1

RNA

  1. XR_004938790.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61880.1 GenPept UniProtKB/Swiss-Prot:Q61880

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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