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Ddx5 DEAD box helicase 5 [ Mus musculus (house mouse) ]

Gene ID: 13207, updated on 11-Apr-2024

Summary

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Official Symbol
Ddx5provided by MGI
Official Full Name
DEAD box helicase 5provided by MGI
Primary source
MGI:MGI:105037
See related
Ensembl:ENSMUSG00000020719 AllianceGenome:MGI:105037
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p68; Hlr1; G17P1; HUMP68; 2600009A06Rik
Summary
Enables RNA binding activity; promoter-specific chromatin binding activity; and transcription coregulator activity. Involved in several processes, including RNA metabolic process; regulation of alternative mRNA splicing, via spliceosome; and regulation of osteoblast differentiation. Acts upstream of or within circadian rhythm; positive regulation of transcription, DNA-templated; and protein import into nucleus. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of catalytic step 2 spliceosome. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human DDX5 (DEAD-box helicase 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 253.6), CNS E14 (RPKM 165.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 E1; 11 70.01 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (106671181..106680011, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (106780355..106789185, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_30946 Neighboring gene predicted gene, 51950 Neighboring gene STARR-positive B cell enhancer ABC_E10724 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:106611859-106612059 Neighboring gene STARR-positive B cell enhancer ABC_E5289 Neighboring gene STARR-positive B cell enhancer ABC_E4006 Neighboring gene mast cell immunoglobulin like receptor 1 Neighboring gene STARR-seq mESC enhancer starr_30947 Neighboring gene STARR-seq mESC enhancer starr_30948 Neighboring gene polymerase (DNA directed), gamma 2, accessory subunit Neighboring gene microRNA 3064 Neighboring gene centrosomal protein 95 Neighboring gene SMAD specific E3 ubiquitin protein ligase 2 Neighboring gene STARR-positive B cell enhancer ABC_E11496 Neighboring gene STARR-positive B cell enhancer ABC_E8465 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:106822918-106823220 Neighboring gene Smad nuclear interacting protein 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Regulation of CD8 T Cell Differentiation by the RNA-Binding Protein DDX5. Louis TL, et al. J Immunol, 2023 Jul 15. PMID 37265401,
  2. RNA binding protein DDX5 restricts RORγt(+) T(reg) suppressor function to promote intestine inflammation. Ma S, et al. Sci Adv, 2023 Feb 3. PMID 36724232, Free PMC Article
  3. The indispensable role of the RNA helicase DDX5 in tumorigenesis induced by the myeloproliferative neoplasm-associated JAK2V617F mutant. Takeda K, et al. Cell Signal, 2023 Feb. PMID 36442590
  4. RNA binding protein DDX5 directs tuft cell specification and function to regulate microbial repertoire and disease susceptibility in the intestine. Long T, et al. Gut, 2022 Sep. PMID 34853057, Free PMC Article
  5. Dual role of the RNA helicase DDX5 in post-transcriptional regulation of myelin basic protein in oligodendrocytes. Hoch-Kraft P, et al. J Cell Sci, 2018 May 1. PMID 29622601

See all (110) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DDX5 inhibits inflammation by modulating m6A levels of TLR2/4 transcripts during bacterial infection.
    Title: DDX5 inhibits inflammation by modulating m6A levels of TLR2/4 transcripts during bacterial infection.
  2. Regulation of CD8 T Cell Differentiation by the RNA-Binding Protein DDX5.
    Title: Regulation of CD8 T Cell Differentiation by the RNA-Binding Protein DDX5.
  3. Identification of DDX5 as an indispensable activator of the glucocorticoid receptor in adipocyte differentiation.
    Title: Identification of DDX5 as an indispensable activator of the glucocorticoid receptor in adipocyte differentiation.
  4. RNA binding protein DDX5 restricts RORgammat[+] Treg suppressor function to promote intestine inflammation.
    Title: RNA binding protein DDX5 restricts RORγt(+) T(reg) suppressor function to promote intestine inflammation.
  5. The indispensable role of the RNA helicase DDX5 in tumorigenesis induced by the myeloproliferative neoplasm-associated JAK2V617F mutant.
    Title: The indispensable role of the RNA helicase DDX5 in tumorigenesis induced by the myeloproliferative neoplasm-associated JAK2V617F mutant.
  6. RNA binding protein DDX5 directs tuft cell specification and function to regulate microbial repertoire and disease susceptibility in the intestine.
    Title: RNA binding protein DDX5 directs tuft cell specification and function to regulate microbial repertoire and disease susceptibility in the intestine.
  7. RNA helicase DDX5 acts as a critical regulator for survival of neonatal mouse gonocytes.
    Title: RNA helicase DDX5 acts as a critical regulator for survival of neonatal mouse gonocytes.
  8. RNA helicase p68 inhibits the transcription and post-transcription of Pkd1 in ADPKD.
    Title: RNA helicase p68 inhibits the transcription and post-transcription of Pkd1 in ADPKD.
  9. RNA helicase DDX5 suppresses IFN-I antiviral innate immune response by interacting with PP2A-Cbeta to deactivate IRF3.
    Title: RNA helicase DDX5 suppresses IFN-I antiviral innate immune response by interacting with PP2A-Cβ to deactivate IRF3.
  10. Induction of DEAD Box helicase 5 in early adipogenesis is regulated by Ten-eleven translocation 2.
    Title: Induction of DEAD Box helicase 5 in early adipogenesis is regulated by Ten-eleven translocation 2.
Submit: New GeneRIF Correction See all GeneRIFs (31)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC118083

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MH2 domain binding ISO
Inferred from Sequence Orthology
more info
  
enables R-SMAD binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
enables SMAD binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear androgen receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables pre-mRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables primary miRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables promoter-specific chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribonucleoprotein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribonucleoprotein complex binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription coregulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in alternative mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in androgen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within circadian rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular estrogen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in intrinsic apoptotic signaling pathway by p53 class mediator ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in miRNA transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in myoblast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear-transcribed mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in primary miRNA processing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein import into nucleus IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of androgen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of skeletal muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IC
Inferred by Curator
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
probable ATP-dependent RNA helicase DDX5
Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5
DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 5
DEAD box RNA helicase DEAD1
DEAD box protein 5
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5
RNA helicase p68
mDEAD1
NP_001342605.1
NP_001342606.1
NP_031866.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355676.1 → NP_001342605.1  probable ATP-dependent RNA helicase DDX5

    Status: VALIDATED

    Source sequence(s)
    AK166698, BC062916, CJ173936
    Consensus CDS
    CCDS25562.1
    UniProtKB/TrEMBL
    A1L333, Q6P5F8, Q8BTS0
    Conserved Domains (2) summary
    pfam08061
    Location:551 → 583
    P68HR; P68HR (NUC004) repeat
    cl26939
    Location:6 → 507
    DEXDc; DEAD-like helicases superfamily

  2. NM_001355677.1 → NP_001342606.1  probable ATP-dependent RNA helicase DDX5

    Status: VALIDATED

    Source sequence(s)
    AL603664, BC062916
    Consensus CDS
    CCDS25562.1
    UniProtKB/TrEMBL
    A1L333, Q6P5F8, Q8BTS0
    Conserved Domains (2) summary
    pfam08061
    Location:551 → 583
    P68HR; P68HR (NUC004) repeat
    cl26939
    Location:6 → 507
    DEXDc; DEAD-like helicases superfamily

  3. NM_007840.3 → NP_031866.2  probable ATP-dependent RNA helicase DDX5

    See identical proteins and their annotated locations for NP_031866.2

    Status: VALIDATED

    Source sequence(s)
    AK166045
    Consensus CDS
    CCDS25562.1
    UniProtKB/TrEMBL
    A1L333, Q6P5F8, Q8BTS0
    Related
    ENSMUSP00000021062.6, ENSMUST00000021062.12
    Conserved Domains (2) summary
    pfam08061
    Location:551 → 583
    P68HR; P68HR (NUC004) repeat
    cl26939
    Location:6 → 507
    DEXDc; DEAD-like helicases superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    106671181..106680011 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61656.2 GenPept UniProtKB/Swiss-Prot:Q61656

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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