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IL17RE interleukin 17 receptor E [ Homo sapiens (human) ]

Gene ID: 132014, updated on 3-Apr-2024

Summary

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Official Symbol
IL17REprovided by HGNC
Official Full Name
interleukin 17 receptor Eprovided by HGNC
Primary source
HGNC:HGNC:18439
See related
Ensembl:ENSG00000163701 MIM:614995; AllianceGenome:HGNC:18439
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a transmembrane protein that functions as the receptor for interleukin-17C. The encoded protein signals to downstream components of the mitogen activated protein kinase (MAPK) pathway. Activity of this protein is important in the immune response to bacterial pathogens. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2013]
Expression
Broad expression in duodenum (RPKM 10.6), skin (RPKM 9.9) and 17 other tissues See more
Orthologs
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Genomic context

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See IL17RE in Genome Data Viewer
Location:
3p25.3
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (9902093..9916402)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (9894115..9908425)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (9944296..9958086)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene cell death inducing DFFA like effector c Neighboring gene Sharpr-MPRA regulatory region 14744 Neighboring gene jagunal homolog 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:9944736-9945405 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14047 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14048 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14049 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:9958035-9958574 Neighboring gene RNA, U6 small nuclear 882, pseudogene Neighboring gene interleukin 17 receptor C Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:9970047-9970546 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14050 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14051 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19413 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:9980935-9981732 Neighboring gene cysteine rich with EGF like domains 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Interleukin 17 receptor E identifies heterogeneous T helper 17 cells in peritoneal fluid of moderate and severe endometriosis patients. Jiang Y, et al. Clin Exp Immunol, 2022 May 12. PMID 35553626, Free PMC Article
  2. Clinical significance of Interleukin 17 receptor E in diabetic nephropathy. Wang J, et al. Int Immunopharmacol, 2023 Jul. PMID 37235960
  3. Evaluation of Interleukin 25 and Interleukin 25 Receptor Expression in Peripheral Blood Mononuclear Cells of Breast Cancer Patients and Normal Subjects. Barati M, et al. J Interferon Cytokine Res, 2020 Mar. PMID 31905037
  4. Allergen-Induced Increases in Interleukin-25 and Interleukin-25 Receptor Expression in Mature Eosinophils from Atopic Asthmatics. Tang W, et al. Int Arch Allergy Immunol, 2016. PMID 27685606
  5. Expression profiles of Th17 pathway related genes in human systemic lupus erythematosus. Pan HF, et al. Mol Biol Rep, 2013 Jan. PMID 23054011

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical significance of Interleukin 17 receptor E in diabetic nephropathy.
    Title: Clinical significance of Interleukin 17 receptor E in diabetic nephropathy.
  2. Interleukin 17 receptor E identifies heterogeneous T helper 17 cells in peritoneal fluid of moderate and severe endometriosis patients.
    Title: Interleukin 17 receptor E identifies heterogeneous T helper 17 cells in peritoneal fluid of moderate and severe endometriosis patients.
  3. Evaluation of Interleukin 25 and Interleukin 25 Receptor Expression in Peripheral Blood Mononuclear Cells of Breast Cancer Patients and Normal Subjects.
    Title: Evaluation of Interleukin 25 and Interleukin 25 Receptor Expression in Peripheral Blood Mononuclear Cells of Breast Cancer Patients and Normal Subjects.
  4. IL-17C/IL-17RE: Emergence of a Unique Axis in TH17 Biology.
    Title: IL-17C/IL-17RE: Emergence of a Unique Axis in T(H)17 Biology.
  5. Our findings suggest that the IL-25/IL-25R axis may play an important role in promoting the recruitment and proinflammatory function of eosinophils in allergic asthma.
    Title: Allergen-Induced Increases in Interleukin-25 and Interleukin-25 Receptor Expression in Mature Eosinophils from Atopic Asthmatics.
  6. IL-17RE as a receptor of IL-17C that regulates early innate immunity to intestinal pathogens.
    Title: IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens.
  7. Observational study of gene-disease association. (HuGE Navigator)
    Title: Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ23658, MGC71884

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables interleukin-17 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
interleukin-17 receptor E
Names
IL-17 receptor E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193380.2 → NP_001180309.1  interleukin-17 receptor E isoform 6 precursor

    See identical proteins and their annotated locations for NP_001180309.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 6, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC018809, AF458069, AK074238, AK096801, AK297697
    Consensus CDS
    CCDS54552.1
    UniProtKB/TrEMBL
    B4DMZ3
    Related
    ENSP00000388086.2, ENST00000454190.6
    Conserved Domains (1) summary
    pfam15037
    Location:75 → 433
    IL17_R_N; Interleukin-17 receptor extracellular region

  2. NM_153480.2 → NP_705613.1  interleukin-17 receptor E isoform 1 precursor

    See identical proteins and their annotated locations for NP_705613.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AF458069, AK074238, BC137077
    Consensus CDS
    CCDS2589.1
    UniProtKB/Swiss-Prot
    B2RB34, B2RNR1, B9EH65, Q6P532, Q8N8H7, Q8N8H8, Q8NFR9, Q8TEC2
    UniProtKB/TrEMBL
    J3KQN7
    Related
    ENSP00000373325.3, ENST00000383814.8
    Conserved Domains (2) summary
    pfam15037
    Location:75 → 448
    IL17_R_N; Interleukin-17 receptor extracellular region
    cl23749
    Location:488 → 611
    TIR_2; TIR domain

  3. NM_153481.2 → NP_705614.1  interleukin-17 receptor E isoform 2

    See identical proteins and their annotated locations for NP_705614.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a portion of the 5' coding region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK074238, AK096801, BC137077
    UniProtKB/Swiss-Prot
    Q8NFR9
    Conserved Domains (2) summary
    pfam15037
    Location:1 → 332
    IL17_R_N; Interleukin-17 receptor extracellular region
    cl23749
    Location:372 → 495
    TIR_2; TIR domain

  4. NM_153483.2 → NP_705616.2  interleukin-17 receptor E isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (5) is longer and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK074238, BC137077, DA592287
    UniProtKB/TrEMBL
    J3KQN7
    Related
    ENSP00000404916.1, ENST00000421412.5
    Conserved Domains (2) summary
    pfam15037
    Location:115 → 488
    IL17_R_N; Interleukin-17 receptor extracellular region
    cl23749
    Location:528 → 651
    TIR_2; TIR domain

RNA

  1. NR_104198.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an exon in the 5' region and uses an alternate splice site in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF458069, AK096793
    Related
    ENST00000383815.7

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    9902093..9916402
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533361.4 → XP_011531663.2  interleukin-17 receptor E isoform X2

  2. XM_047447458.1 → XP_047303414.1  interleukin-17 receptor E isoform X1

    UniProtKB/Swiss-Prot
    B2RB34, B2RNR1, B9EH65, Q6P532, Q8N8H7, Q8N8H8, Q8NFR9, Q8TEC2

  3. XM_047447460.1 → XP_047303416.1  interleukin-17 receptor E isoform X4

  4. XM_011533362.3 → XP_011531664.1  interleukin-17 receptor E isoform X7

    UniProtKB/TrEMBL
    B4DMZ3
    Conserved Domains (1) summary
    pfam15037
    Location:75 → 366
    IL17_R_N; Interleukin-17 receptor extracellular region

  5. XM_024453350.2 → XP_024309118.1  interleukin-17 receptor E isoform X5

    UniProtKB/TrEMBL
    B4DMZ3
    Conserved Domains (1) summary
    pfam15037
    Location:79 → 432
    IL17_R_N; Interleukin-17 receptor extracellular region

  6. XM_047447462.1 → XP_047303418.1  interleukin-17 receptor E isoform X8

  7. XM_011533364.3 → XP_011531666.1  interleukin-17 receptor E isoform X10

    Conserved Domains (1) summary
    pfam15037
    Location:75 → 366
    IL17_R_N; Interleukin-17 receptor extracellular region

  8. XM_011533363.3 → XP_011531665.1  interleukin-17 receptor E isoform X9

    Conserved Domains (1) summary
    pfam15037
    Location:75 → 409
    IL17_R_N; Interleukin-17 receptor extracellular region

  9. XM_047447459.1 → XP_047303415.1  interleukin-17 receptor E isoform X3

  10. XM_006712976.2 → XP_006713039.1  interleukin-17 receptor E isoform X6

    See identical proteins and their annotated locations for XP_006713039.1

    UniProtKB/Swiss-Prot
    Q8NFR9
    Conserved Domains (2) summary
    pfam15037
    Location:1 → 332
    IL17_R_N; Interleukin-17 receptor extracellular region
    cl23749
    Location:372 → 495
    TIR_2; TIR domain

  11. XM_047447464.1 → XP_047303420.1  interleukin-17 receptor E isoform X12

  12. XM_047447463.1 → XP_047303419.1  interleukin-17 receptor E isoform X11

RNA

  1. XR_940382.4 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    9894115..9908425
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054345267.1 → XP_054201242.1  interleukin-17 receptor E isoform X2

  2. XM_054345266.1 → XP_054201241.1  interleukin-17 receptor E isoform X1

    UniProtKB/Swiss-Prot
    B2RB34, B2RNR1, B9EH65, Q6P532, Q8N8H7, Q8N8H8, Q8NFR9, Q8TEC2

  3. XM_054345269.1 → XP_054201244.1  interleukin-17 receptor E isoform X4

  4. XM_054345270.1 → XP_054201245.1  interleukin-17 receptor E isoform X5

  5. XM_054345272.1 → XP_054201247.1  interleukin-17 receptor E isoform X7

  6. XM_054345273.1 → XP_054201248.1  interleukin-17 receptor E isoform X8

  7. XM_054345275.1 → XP_054201250.1  interleukin-17 receptor E isoform X10

  8. XM_054345274.1 → XP_054201249.1  interleukin-17 receptor E isoform X9

  9. XM_054345268.1 → XP_054201243.1  interleukin-17 receptor E isoform X3

  10. XM_054345271.1 → XP_054201246.1  interleukin-17 receptor E isoform X6

  11. XM_054345277.1 → XP_054201252.1  interleukin-17 receptor E isoform X12

  12. XM_054345276.1 → XP_054201251.1  interleukin-17 receptor E isoform X11

RNA

  1. XR_008486659.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_144640.2: Suppressed sequence

    Description
    NM_144640.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NFR9.1 GenPept UniProtKB/Swiss-Prot:Q8NFR9

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