Dazl deleted in azoospermia-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dazlprovided by MGI
Official Full Name: deleted in azoospermia-likeprovided by MGI
Primary source: MGI:MGI:1342328
See related: Ensembl:ENSMUSG00000010592 AllianceGenome:MGI:1342328
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dazh; Tpx2; Dazl1; Dazla; Tpx-2; Daz-like
Summary: This gene encodes a member of the depleted in azoospermia-like (DAZL) protein family. Members of this family contain an RNA recognition motif, interact with poly A binding proteins, and may be involved in the initiation of translation. The encoded protein is expressed in the cytoplasm of pluripotent stem cells, and in both male and female germ cells, where it is essential for gametogenesis. Disruption of this gene is associated with infertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]
Expression: Biased expression in testis adult (RPKM 15.0) and ovary adult (RPKM 0.8) See more
Orthologs: human all
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Genomic context

Location:: 17 C; 17 25.86 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (50586422..50600627, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (50279393..50293620, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Somatic cell-derived BMPs induce premature meiosis in male germ cells during the embryonic stage by upregulating Dazl expression.
Title: Somatic cell-derived BMPs induce premature meiosis in male germ cells during the embryonic stage by upregulating Dazl expression.
The RNA-binding protein DAZL functions as repressor and activator of mRNA translation during oocyte maturation. Mutagenesis of putative DAZL-binding sites in these mRNAs mimics the effect of DAZL depletion. These findings demonstrate that DAZL regulates translation of maternal mRNAs, functioning both as the translational repressor and activator during oocyte maturation.
Title: The RNA-binding protein DAZL functions as repressor and activator of mRNA translation during oocyte maturation.
These DAZL functions as a master regulator of a post-transcriptional mRNA program essential for germ cell survival.
Title: DAZL Regulates Germ Cell Survival through a Network of PolyA-Proximal mRNA Interactions.
The 3'-UTR-dependent suppression of DAZL in mouse follicular oocytes is required for the progression of normal pre-implantation development.
Title: Requirement of the 3'-UTR-dependent suppression of DAZL in oocytes for pre-implantation mouse development.
Down-regulated expression of Sox9 and Dazl may play important roles in MBP-induced testis injury.
Title: Mono-butyl phthalate-induced mouse testis injury is associated with oxidative stress and down-regulated expression of Sox9 and Dazl.
DAZL and CPEB1 regulate mRNA translation during oocyte maturation.
Title: DAZL and CPEB1 regulate mRNA translation synergistically during oocyte maturation.
findings demonstrate that DAZL associates with mRNA of Tet1, a catalyst of 5-hydroxylation of methyl-cytosine, and enhances Tet1 mRNA translation; DAZL enhances TET1-mediated cytosine hydroxymethylation in embryonic stem cells that are actively reprogramming to a pluripotent ground state
Title: DAZL regulates Tet1 translation in murine embryonic stem cells.
Both yeast and mouse contain an RNA-binding protein, Rim4 and DAZL, respectively, that functions in translation and forms SDS-resistant aggregates during gametogenesis.
Title: Regulated Formation of an Amyloid-like Translational Repressor Governs Gametogenesis.
Our findings strengthen the importance of RA and Dazl in the meiotic transition, provide important details about the Stra8 pathway, and open avenues to investigate early meiosis through analysis of Rec8 induction and function
Title: Retinoic acid activates two pathways required for meiosis in mice.
Data indicate that the germ cell-specific RNA binding protein DAZL limits both pluripotency and somatic differentiation in nascent primordial germ cells (PGCs).
Title: DAZL limits pluripotency, differentiation, and apoptosis in developing primordial germ cells.

Submit: New GeneRIF Correction See all GeneRIFs (32)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dazl (e-PCR), detects polymorphism
- UniSTS:234033

G65760 (e-PCR)
- UniSTS:225895

Dazl (e-PCR), detects polymorphism
- UniSTS:498795

Dazl (e-PCR), detects polymorphism
- UniSTS:479093

Dazl (e-PCR), detects polymorphism
- UniSTS:497291

Dazl (e-PCR), detects polymorphism
- UniSTS:275892

Dazl (e-PCR), detects polymorphism
- UniSTS:548036

Dazl (e-PCR), detects polymorphism
- UniSTS:142831

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables translation activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation activator activity	IDA Inferred from Direct Assay more info	PubMed
enables translation activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 3'-UTR-mediated mRNA stabilization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within female meiosis II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within oocyte maturation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within oogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of translational initiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of translation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in ribosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: deleted in azoospermia-like

Names: DAZ-like autosomal; deleted in azoospermia-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001277863.2 → NP_001264792.1 deleted in azoospermia-like isoform 2

See identical proteins and their annotated locations for NP_001264792.1

Status: VALIDATED

Source sequence(s)

AL592112

UniProtKB/TrEMBL

Q499F1

Conserved Domains (2) summary

COG0724
Location:33 → 113

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12672
Location:35 → 116

RRM_DAZL; RNA recognition motif in vertebrate deleted in azoospermia-like (DAZL) proteins
NM_010021.6 → NP_034151.3 deleted in azoospermia-like isoform 1

See identical proteins and their annotated locations for NP_034151.3

Status: VALIDATED

Source sequence(s)

AL592112

Consensus CDS

CCDS37649.1

UniProtKB/Swiss-Prot

Q64368

UniProtKB/TrEMBL

Q499F1

Related

ENSMUSP00000010736.8, ENSMUST00000010736.9

Conserved Domains (2) summary

TIGR01628
Location:40 → 208

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12672
Location:35 → 116

RRM_DAZL; RNA recognition motif in vertebrate deleted in azoospermia-like (DAZL) proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

50586422..50600627 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006523583.4 → XP_006523646.1 deleted in azoospermia-like isoform X1

Conserved Domains (2) summary

TIGR01628
Location:150 → 318

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12672
Location:145 → 226

RRM_DAZL; RNA recognition motif in vertebrate deleted in azoospermia-like (DAZL) proteins