Cyp2c40 cytochrome P450, family 2, subfamily c, polypeptide 40 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cyp2c40provided by MGI
Official Full Name: cytochrome P450, family 2, subfamily c, polypeptide 40provided by MGI
Primary source: MGI:MGI:1306815
See related: Ensembl:ENSMUSG00000025004 AllianceGenome:MGI:1306815
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables arachidonic acid 14,15-epoxygenase activity. Predicted to be involved in epoxygenase P450 pathway and xenobiotic metabolic process. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in embryo; liver; and metanephros. Human ortholog(s) of this gene implicated in several diseases, including Plasmodium falciparum malaria; eosinophilic esophagitis; glucose metabolism disease (multiple); invasive aspergillosis; and multiple chemical sensitivity. Orthologous to human CYP2C19 (cytochrome P450 family 2 subfamily C member 19) and CYP2C9 (cytochrome P450 family 2 subfamily C member 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 249.7) and liver E18 (RPKM 201.4) See more
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Genomic context

Location:: 19 C3; 19 34.24 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (39755517..39801258, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (39767073..39812814, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI662255 (e-PCR)
- UniSTS:166149

AI265721 (e-PCR)
- UniSTS:160833

Cyp2c40 (e-PCR), detects polymorphism
- UniSTS:462993

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables arachidonic acid 14,15-epoxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables arachidonic acid epoxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in epoxygenase P450 pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome P450 2C40

Names: CYPIIC40; cytochrome P450, 2c40

NP_034134.3

EC 1.14.14.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010004.3 → NP_034134.3 cytochrome P450 2C40 precursor

Status: VALIDATED

Source sequence(s)

AC121935

Consensus CDS

CCDS29798.3

UniProtKB/Swiss-Prot

B2RTP3, P56657

UniProtKB/TrEMBL

Q8VCP4

Related

ENSMUSP00000125217.3, ENSMUST00000160476.9

Conserved Domains (1) summary

pfam00067
Location:30 → 487

p450; Cytochrome P450