Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cyp26a1provided by MGI
Official Full Name: cytochrome P450, family 26, subfamily a, polypeptide 1provided by MGI
Primary source: MGI:MGI:1096359
See related: Ensembl:ENSMUSG00000024987 AllianceGenome:MGI:1096359
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RAH; Cyp26; P450RA; P450RAI
Summary: Enables retinoic acid 4-hydroxylase activity. Involved in retinoic acid catabolic process. Acts upstream of or within several processes, including anterior/posterior pattern specification; cellular response to retinoic acid; and neural crest cell development. Predicted to be located in endoplasmic reticulum and membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; extraembryonic component; and sensory organ. Orthologous to human CYP26A1 (cytochrome P450 family 26 subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 38.3) and ovary adult (RPKM 6.7) See more
Orthologs: human all
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Genomic context

Location:: 19 C2; 19 32.36 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (37686186..37689984)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (37697738..37701536)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cyp26a1 supports postnatal retinoic acid homeostasis and glucoregulatory control.
Title: Cyp26a1 supports postnatal retinoic acid homeostasis and glucoregulatory control.
Cytochrome P450 26A1 Modulates the Polarization of Uterine Macrophages During the Peri-Implantation Period.
Title: Cytochrome P450 26A1 Modulates the Polarization of Uterine Macrophages During the Peri-Implantation Period.
Knockout of Cyp26a1 and Cyp26b1 during postnatal life causes reduced lifespan, dermatitis, splenomegaly, and systemic inflammation in mice.
Title: Knockout of Cyp26a1 and Cyp26b1 during postnatal life causes reduced lifespan, dermatitis, splenomegaly, and systemic inflammation in mice.
findings demonstrate that despite lacking a major impact on endogenous all-trans-retinoic acid (atRA) signaling, Cyp26a1 critically contributes as a barrier for exogenous atRA exposure
Title: The retinoic acid hydroxylase Cyp26a1 has minor effects on postnatal vitamin A homeostasis, but is required for exogenous atRA clearance.
Loss of Strap selectively induced Cyp26A1 expression in mouse EBs, suggesting a potential role of STRAP in RA signaling.
Title: Serine Threonine Kinase Receptor-Associated Protein Deficiency Impairs Mouse Embryonic Stem Cells Lineage Commitment Through CYP26A1-Mediated Retinoic Acid Homeostasis.
We found that developing teeth from K14-CRE/Shhf/f mutant mice exhibit severe downregulation of Cyp26a1 and Cyp26c1 expression levels in the inner dental epithelium
Title: Sonic Hedgehog Signaling Is Required for Cyp26 Expression during Embryonic Development.
These findings provide a new line of evidence correlating the deleterious effects of blocking CYP26A1 in pregnancy with the aberrant regulation of NK cells in the uterus.
Title: Cytochrome P450 26A1 modulates natural killer cells in mouse early pregnancy.
Cyp26a1, which encodes a key enzyme for catabolic inactivation of retinoic acid (RA) required for tight control of local RA concentrations, is significantly downregulated in embryos of diabetic mice. Embryonic tissues expressing Cyp26a1 show reduced efficiency of RA clearance.
Title: Perturbation of Retinoid Homeostasis Increases Malformation Risk in Embryos Exposed to Pregestational Diabetes.
These results suggest that CYP2R1 and CYP26A1 may play a major role in hepatoblast cell differentiation during the development of the liver.
Title: Role of the Drug-Metabolizing Enzyme CYP during Mouse Liver Development.
The results of this study suggest that CYP2R1 and CYP26A1 are important in the differentiation of oval cells into hepatoblast-like cells in the injured liver
Title: Analysis of CYP2R1 and CYP26A1 Expression Patterns in Regeneration in Mice with Liver Injury.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

PMC312609P1 (e-PCR)
- UniSTS:272904

Cyp26a1 (e-PCR), detects polymorphism
- UniSTS:516133

Cyp26a1 (e-PCR), detects polymorphism
- UniSTS:516134

PMC207565P3 (e-PCR)
- UniSTS:271953

UniSTS:462985 (e-PCR)
- UniSTS:462985

Cyp26a1 (e-PCR), detects polymorphism
- UniSTS:462985

Cyp26a1 (e-PCR), detects polymorphism
- UniSTS:525747

Cyp26a1 (e-PCR), detects polymorphism
- UniSTS:275891

Cyp26a1 (e-PCR), detects polymorphism
- UniSTS:508365

Cyp26a1 (e-PCR), detects polymorphism
- UniSTS:506830

Cyp26a1 (e-PCR), detects polymorphism
- UniSTS:519407

Cyp26a1 (e-PCR), detects polymorphism
- UniSTS:516091

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables all-trans retinoic acid 18-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	ISO Inferred from Sequence Orthology more info
enables retinoic acid 4-hydroxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables retinoic acid 4-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables retinoic acid binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anterior/posterior pattern specification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within anterior/posterior pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to retinoic acid	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within central nervous system development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neural crest cell development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in retinoic acid catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within retinoic acid catabolic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in retinoic acid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinoic acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within retinoic acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retinoic acid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of retinoic acid receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within retinoic acid receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sterol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in xenobiotic metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome P450 26A1

Names: cytochrome P450, 26, retinoic acid A1; cytochrome P450RAI; retinoic acid 4-hydroxylase; retinoic acid hydrolase; retinoic acid-metabolizing cytochrome

NP_031837.2

EC 1.14.-.-

EC 1.14.13.-

XP_017173542.1

EC 1.14.-.-

EC 1.14.13.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007811.2 → NP_031837.2 cytochrome P450 26A1

See identical proteins and their annotated locations for NP_031837.2

Status: VALIDATED

Source sequence(s)

AA239785, CB574526, CJ217321, CK626921

Consensus CDS

CCDS29780.1

UniProtKB/Swiss-Prot

O55127, Q9R1F4

UniProtKB/TrEMBL

A0A0R4J061

Related

ENSMUSP00000025946.6, ENSMUST00000025946.7

Conserved Domains (1) summary

cl12078
Location:43 → 491

p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

37686186..37689984

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017318053.2 → XP_017173542.1 cytochrome P450 26A1 isoform X1

UniProtKB/Swiss-Prot

O55127, Q9R1F4

Conserved Domains (1) summary

cl12078
Location:4 → 422

p450; Cytochrome P450