Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cyp17a1provided by MGI
Official Full Name: cytochrome P450, family 17, subfamily a, polypeptide 1provided by MGI
Primary source: MGI:MGI:88586
See related: Ensembl:ENSMUSG00000003555 AllianceGenome:MGI:88586
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cyp17; p450c17
Summary: Enables steroid 17-alpha-monooxygenase activity. Acts upstream of or within glucocorticoid biosynthetic process. Located in axon and neuronal cell body. Is expressed in several structures, including adrenal gland; gut; nervous system; reproductive system; and retina layer. Human ortholog(s) of this gene implicated in several diseases, including cholelithiasis; congenital adrenal hyperplasia; gallbladder cancer; osteoporosis; and prostate cancer. Orthologous to human CYP17A1 (cytochrome P450 family 17 subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in ovary adult (RPKM 93.6), testis adult (RPKM 75.6) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C3; 19 38.97 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (46655604..46661439, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (46667165..46673000, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mutated CYP17A1 promotes atherosclerosis and early-onset coronary artery disease.
Title: Mutated CYP17A1 promotes atherosclerosis and early-onset coronary artery disease.
Hydroxylation and lyase reactions of steroids catalyzed by mouse cytochrome P450 17A1 (Cyp17a1).
Title: Hydroxylation and lyase reactions of steroids catalyzed by mouse cytochrome P450 17A1 (Cyp17a1).
Effect of Differences in the Microbiome of Cyp17a1-Deficient Mice on Atherosclerotic Background.
Title: Effect of Differences in the Microbiome of Cyp17a1-Deficient Mice on Atherosclerotic Background.
Effect of the spatial-temporal specific theca cell Cyp17 overexpression on the reproductive phenotype of the novel TC17 mouse.
Title: Effect of the spatial-temporal specific theca cell Cyp17 overexpression on the reproductive phenotype of the novel TC17 mouse.
CYP17A1 deficient XY mice display susceptibility to atherosclerosis, altered lipidomic profile and atypical sex development.
Title: CYP17A1 deficient XY mice display susceptibility to atherosclerosis, altered lipidomic profile and atypical sex development.
spinal P450c17 activates astrocytes via p38 phosphorylation.
Title: Inhibition of cytochrome P450c17 reduces spinal astrocyte activation in a mouse model of neuropathic pain via regulation of p38 MAPK phosphorylation.
through mouse-to-human search and validation, we found that CYP17A1 is overexpressed in hepatocellular carcinomas and it has great potentiality as a noninvasive marker for hepatocellular carcinoma detection
Title: Transcriptome Analysis of WHV/c-myc Transgenic Mice Implicates Cytochrome P450 Enzyme 17A1 as a Promising Biomarker for Hepatocellular Carcinoma.
Demonstration of the physiologic importance of cytochrome b5 activating the 17,20-lyase reaction and the production of 19-carbon sex steroids from 21-carbon precursors in mice.
Title: Impaired 17,20-Lyase Activity in Male Mice Lacking Cytochrome b5 in Leydig Cells.
TRalpha/T3 directly acts on the P450c17 promoter, which contains putative thyroid response elements, and indirectly acts on the promoter of steroidogenic enzyme genes by modulating Nur77 transactivation on these promoters.
Title: Differential regulation of steroidogenic enzyme genes by TRα signaling in testicular Leydig cells.
ata indicate that androgen receptor (AR) regulation on Klk27, Rhox5, Eppin, and Cyp17 genes in adult mouse testis using chromatin immunoprecipitation (ChIP) assays.
Title: Androgen receptor binding sites identified in mouse testis.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M64863 (e-PCR)
- UniSTS:181250

UniSTS:464662 (e-PCR)
- UniSTS:464662

Cyp17a1 (e-PCR), detects polymorphism
- UniSTS:464662

Cyp17a1 (e-PCR), detects polymorphism
- UniSTS:531493

UniSTS:257093 (e-PCR)
- UniSTS:257093

Cyp17a1 (e-PCR), detects polymorphism
- UniSTS:257093

Cyp17a1 (e-PCR), detects polymorphism
- UniSTS:256605

Cyp17a1 (e-PCR), detects polymorphism
- UniSTS:256885

Cyp17a1 (e-PCR), detects polymorphism
- UniSTS:462978

NoName (e-PCR)
- UniSTS:225230

Cyp17 (e-PCR), detects polymorphism
- UniSTS:226047

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 17-alpha-hydroxyprogesterone aldolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 17-alpha-hydroxyprogesterone aldolase activity	ISO Inferred from Sequence Orthology more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables steroid 17-alpha-monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables steroid 17-alpha-monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables steroid 17-alpha-monooxygenase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables steroid 17-alpha-monooxygenase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within glucocorticoid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in hormone biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in hormone biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of steroid hormone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in progesterone metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in progesterone metabolic process	ISO Inferred from Sequence Orthology more info
involved_in steroid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in steroid metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: steroid 17-alpha-hydroxylase/17,20 lyase

Names: 17-alpha-hydroxyprogesterone aldolase; CYPXVII; cytochrome P450 17A1; cytochrome P450, 17; cytochrome P450, 17a1; cytochrome P450-C17; cytochrome P450c17; steroid 17-alpha hydroxylase; steroid 17-alpha-monooxygenase

NP_031835.3

EC 1.14.14.19

EC 1.14.14.32

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.