Csf3r colony stimulating factor 3 receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Csf3rprovided by MGI
Official Full Name: colony stimulating factor 3 receptorprovided by MGI
Primary source: MGI:MGI:1339755
See related: Ensembl:ENSMUSG00000028859 AllianceGenome:MGI:1339755
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cd114; Csfgr; G-CSFR; G-CSF-R
Summary: Enables granulocyte colony-stimulating factor binding activity. Acts upstream of or within neutrophil chemotaxis and regulation of myeloid cell differentiation. Predicted to be located in endocytic vesicle membrane and plasma membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including bone marrow; dorsal aorta; early conceptus; gut; and reproductive system. Used to study hereditary neutrophilia. Human ortholog(s) of this gene implicated in hematologic cancer (multiple) and severe congenital neutropenia (multiple). Orthologous to human CSF3R (colony stimulating factor 3 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 12.5), lung adult (RPKM 7.8) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.2; 4 59.77 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (125917241..125938233)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (126023441..126044975)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The RNA m[6]A demethylase ALKBH5 drives emergency granulopoiesis and neutrophil mobilization by upregulating G-CSFR expression.
Title: The RNA m(6)A demethylase ALKBH5 drives emergency granulopoiesis and neutrophil mobilization by upregulating G-CSFR expression.
G-CSF Receptor Deletion Amplifies Cortical Bone Dysfunction in Mice With STAT3 Hyperactivation in Osteocytes.
Title: G-CSF Receptor Deletion Amplifies Cortical Bone Dysfunction in Mice With STAT3 Hyperactivation in Osteocytes.
Alternatively spliced CSF3R isoforms in SRSF2 P95H mutated myeloid neoplasms.
Title: Alternatively spliced CSF3R isoforms in SRSF2 P95H mutated myeloid neoplasms.
Effect of the unfolded protein response and oxidative stress on mutagenesis in CSF3R: a model for evolution of severe congenital neutropenia to myelodysplastic syndrome/acute myeloid leukemia.
Title: Effect of the unfolded protein response and oxidative stress on mutagenesis in CSF3R: a model for evolution of severe congenital neutropenia to myelodysplastic syndrome/acute myeloid leukemia.
G-CSF and G-CSFR Modulate CD4 and CD8 T Cell Responses to Promote Colon Tumor Growth and Are Potential Therapeutic Targets.
Title: G-CSF and G-CSFR Modulate CD4 and CD8 T Cell Responses to Promote Colon Tumor Growth and Are Potential Therapeutic Targets.
beta-Catenin-TCF/LEF signaling promotes steady-state and emergency granulopoiesis via G-CSF receptor upregulation.
Title: β-Catenin-TCF/LEF signaling promotes steady-state and emergency granulopoiesis via G-CSF receptor upregulation.
Chimeric G-CSF Receptor-Mediated STAT3 Activation Contributes to Efficient Induction of Cardiomyocytes from Mouse Induced Pluripotent Stem Cells.
Title: Chimeric G-CSF Receptor-Mediated STAT3 Activation Contributes to Efficient Induction of Cardiomyocytes from Mouse Induced Pluripotent Stem Cells.
T618I CSF3R mutations in chronic neutrophilic leukemia induce oncogenic signals through aberrant trafficking and constitutive phosphorylation of the O-glycosylated receptor form.
Title: T618I CSF3R mutations in chronic neutrophilic leukemia induce oncogenic signals through aberrant trafficking and constitutive phosphorylation of the O-glycosylated receptor form.
G-CSF signaling in CerS6 null bone marrow cells was not affected. In conclusion, very long chain ceramides are important for G-CSF signaling and translocation of G-CSF-R into detergent-resistant membranes.
Title: Role of ceramide synthase 2 in G-CSF signaling and G-CSF-R translocation into detergent-resistant membranes.
The results illustrate that Clostridium perfringens alpha-toxin disturbs G-CSF-mediated granulopoiesis by reducing the expression of G-CSFR on neutrophils while augmenting septic shock.
Title: Clostridium perfringens α-toxin impairs granulocyte colony-stimulating factor receptor-mediated granulocyte production while triggering septic shock.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (8) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Csf3r (e-PCR), detects polymorphism
- UniSTS:265218

M58288 (e-PCR)
- UniSTS:159283

PMC123164P1 (e-PCR)
- UniSTS:270441

Csf3r (e-PCR), detects polymorphism
- UniSTS:256390

Csf3r (e-PCR), detects polymorphism
- UniSTS:516502

Csf3r (e-PCR), detects polymorphism
- UniSTS:516846

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables granulocyte colony-stimulating factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in immunoglobulin mediated immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neutrophil chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of myeloid cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in endocytic vesicle membrane	TAS Traceable Author Statement more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: granulocyte colony-stimulating factor receptor

Names: G-CSF receptor; colony stimulating factor 3 receptor (granulocyte)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252651.2 → NP_001239580.1 granulocyte colony-stimulating factor receptor isoform 2 precursor

See identical proteins and their annotated locations for NP_001239580.1

Status: VALIDATED

Source sequence(s)

AL627101

UniProtKB/TrEMBL

Q14BI3

Conserved Domains (4) summary

smart00060
Location:422 → 503

FN3; Fibronectin type 3 domain

cd00063
Location:246 → 318

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06328
Location:24 → 111

Lep_receptor_Ig; Ig-like C2-type domain

cl21522
Location:123 → 221

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
NM_001420891.1 → NP_001407820.1 granulocyte colony-stimulating factor receptor isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AL627101

UniProtKB/Swiss-Prot

A2A8Y3, P40223
NM_001420892.1 → NP_001407821.1 granulocyte colony-stimulating factor receptor isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AL627101

UniProtKB/Swiss-Prot

A2A8Y3, P40223
NM_001420893.1 → NP_001407822.1 granulocyte colony-stimulating factor receptor isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AL627101

UniProtKB/Swiss-Prot

A2A8Y3, P40223
NM_001420894.1 → NP_001407823.1 granulocyte colony-stimulating factor receptor isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AL627101

UniProtKB/Swiss-Prot

A2A8Y3, P40223
NM_001420895.1 → NP_001407824.1 granulocyte colony-stimulating factor receptor isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AL627101

UniProtKB/Swiss-Prot

A2A8Y3, P40223
NM_001420896.1 → NP_001407825.1 granulocyte colony-stimulating factor receptor isoform 3

Status: VALIDATED

Source sequence(s)

AL627101
NM_007782.4 → NP_031808.2 granulocyte colony-stimulating factor receptor isoform 1 precursor

See identical proteins and their annotated locations for NP_031808.2

Status: VALIDATED

Source sequence(s)

AL627101

Consensus CDS

CCDS18640.1

UniProtKB/Swiss-Prot

A2A8Y3, P40223

UniProtKB/TrEMBL

Q14AY3

Related

ENSMUSP00000101768.2, ENSMUST00000106162.8

Conserved Domains (4) summary

smart00060
Location:530 → 611

FN3; Fibronectin type 3 domain

cd00063
Location:354 → 426

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06328
Location:24 → 111

Lep_receptor_Ig; Ig-like C2-type domain

cl21522
Location:123 → 221

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RNA

NR_045561.2 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL627101
NR_185211.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL627101
NR_185212.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL627101
NR_185213.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL627101
NR_185214.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL627101

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

125917241..125938233

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006502709.3 → XP_006502772.1 granulocyte colony-stimulating factor receptor isoform X1

See identical proteins and their annotated locations for XP_006502772.1

UniProtKB/Swiss-Prot

A2A8Y3, P40223

UniProtKB/TrEMBL

Q14AY3

Conserved Domains (4) summary

smart00060
Location:530 → 611

FN3; Fibronectin type 3 domain

cd00063
Location:354 → 426

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06328
Location:24 → 111

Lep_receptor_Ig; Ig-like C2-type domain

cl21522
Location:123 → 221

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_017319945.3 → XP_017175434.1 granulocyte colony-stimulating factor receptor isoform X5

Conserved Domains (3) summary

smart00060
Location:223 → 304

FN3; Fibronectin type 3 domain

cd00063
Location:47 → 119

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21522
Location:126 → 211

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_006502710.5 → XP_006502773.1 granulocyte colony-stimulating factor receptor isoform X1

See identical proteins and their annotated locations for XP_006502773.1

UniProtKB/Swiss-Prot

A2A8Y3, P40223

UniProtKB/TrEMBL

Q14AY3

Conserved Domains (4) summary

smart00060
Location:530 → 611

FN3; Fibronectin type 3 domain

cd00063
Location:354 → 426

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06328
Location:24 → 111

Lep_receptor_Ig; Ig-like C2-type domain

cl21522
Location:123 → 221

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_036163628.1 → XP_036019521.1 granulocyte colony-stimulating factor receptor isoform X3

UniProtKB/TrEMBL

Q14AY3

Conserved Domains (2) summary

smart00060
Location:397 → 478

FN3; Fibronectin type 3 domain

cd00063
Location:221 → 293

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_006502711.5 → XP_006502774.1 granulocyte colony-stimulating factor receptor isoform X1

See identical proteins and their annotated locations for XP_006502774.1

UniProtKB/Swiss-Prot

A2A8Y3, P40223

UniProtKB/TrEMBL

Q14AY3

Conserved Domains (4) summary

smart00060
Location:530 → 611

FN3; Fibronectin type 3 domain

cd00063
Location:354 → 426

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06328
Location:24 → 111

Lep_receptor_Ig; Ig-like C2-type domain

cl21522
Location:123 → 221

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_011240423.4 → XP_011238725.1 granulocyte colony-stimulating factor receptor isoform X2

See identical proteins and their annotated locations for XP_011238725.1

UniProtKB/TrEMBL

Q14BI3

Conserved Domains (4) summary

smart00060
Location:422 → 503

FN3; Fibronectin type 3 domain

cd00063
Location:246 → 318

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06328
Location:24 → 111

Lep_receptor_Ig; Ig-like C2-type domain

cl21522
Location:123 → 221

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_006502717.3 → XP_006502780.1 granulocyte colony-stimulating factor receptor isoform X3

See identical proteins and their annotated locations for XP_006502780.1

UniProtKB/TrEMBL

Q14AY3

Conserved Domains (2) summary

smart00060
Location:397 → 478

FN3; Fibronectin type 3 domain

cd00063
Location:221 → 293

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_006502719.3 → XP_006502782.1 granulocyte colony-stimulating factor receptor isoform X6

Conserved Domains (2) summary

smart00060
Location:172 → 253

FN3; Fibronectin type 3 domain

cl21522
Location:75 → 160

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...