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Csf2 colony stimulating factor 2 (granulocyte-macrophage) [ Mus musculus (house mouse) ]

Gene ID: 12981, updated on 13-Jan-2025

Summary

Official Symbol
Csf2provided by MGI
Official Full Name
colony stimulating factor 2 (granulocyte-macrophage)provided by MGI
Primary source
MGI:MGI:1339752
See related
Ensembl:ENSMUSG00000018916 AllianceGenome:MGI:1339752
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CSF; Csfgm; GMCSF; Gm-CSf; MGI-IGM
Summary
Enables cytokine activity. Acts upstream of or within several processes, including embryonic placenta development; myeloid leukocyte differentiation; and positive regulation of cell population proliferation. Located in extracellular space. Is expressed in several structures, including genitourinary system; hemolymphoid system; liver; lung; and trophectoderm. Used to study pulmonary alveolar proteinosis. Human ortholog(s) of this gene implicated in acute myeloid leukemia; juvenile myelomonocytic leukemia; neutropenia; pulmonary alveolar proteinosis; and visceral leishmaniasis. Orthologous to human CSF2 (colony stimulating factor 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Csf2 in Genome Data Viewer
Location:
11 B1.3; 11 32.13 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (54138096..54140725, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (54247270..54249899, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12223 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:53976423-53976624 Neighboring gene Sdccag3 pseudogene Neighboring gene RIKEN cDNA 4933405E24 gene Neighboring gene STARR-positive B cell enhancer mm9_chr11:53999404-53999705 Neighboring gene STARR-seq mESC enhancer starr_29505 Neighboring gene acyl-CoA-binding protein ACBP pseudogene Neighboring gene interleukin 3 Neighboring gene predicted gene, 51861

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (11) 
  • Targeted (10)  1 citation

Pathways from PubChem

General gene information

Clone Names

  • MGC151255, MGC151257

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity  
enables cytokine activity PubMed 
enables cytokine activity  
enables cytokine activity  
enables granulocyte macrophage colony-stimulating factor receptor binding  
enables growth factor activity  
Items 1 - 25 of 40
Process Evidence Code Pubs
acts_upstream_of cell population proliferation PubMed 
involved_in cell surface receptor signaling pathway via JAK-STAT  
involved_in cell surface receptor signaling pathway via JAK-STAT  
involved_in cellular response to granulocyte macrophage colony-stimulating factor stimulus  
involved_in cellular response to granulocyte macrophage colony-stimulating factor stimulus  
involved_in dendritic cell differentiation  
acts_upstream_of_or_within embryonic placenta development PubMed 
involved_in epithelial fluid transport  
involved_in granulocyte-macrophage colony-stimulating factor signaling pathway  
involved_in granulocyte-macrophage colony-stimulating factor signaling pathway  
involved_in histamine secretion  
involved_in immune response  
involved_in macrophage differentiation  
involved_in macrophage differentiation  
acts_upstream_of_or_within monocyte differentiation PubMed 
involved_in myeloid cell differentiation  
acts_upstream_of_or_within myeloid dendritic cell differentiation PubMed 
involved_in myeloid dendritic cell differentiation  
involved_in negative regulation of DNA-templated transcription  
involved_in negative regulation of DNA-templated transcription  
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
acts_upstream_of_or_within neutrophil differentiation PubMed 
involved_in positive regulation of cell migration  
acts_upstream_of_or_within positive regulation of cell population proliferation PubMed 
involved_in positive regulation of cell population proliferation  
involved_in positive regulation of gene expression  
involved_in positive regulation of interleukin-23 production  
involved_in positive regulation of interleukin-23 production  
involved_in positive regulation of leukocyte proliferation  
involved_in positive regulation of leukocyte proliferation  
involved_in positive regulation of macrophage derived foam cell differentiation  
involved_in positive regulation of macrophage derived foam cell differentiation  
involved_in positive regulation of podosome assembly  
involved_in positive regulation of podosome assembly  
involved_in positive regulation of tyrosine phosphorylation of STAT protein  
acts_upstream_of_or_within regulation of cell population proliferation PubMed 
involved_in regulation of circadian sleep/wake cycle, sleep  
acts_upstream_of_or_within regulation of gene expression PubMed 
acts_upstream_of_or_within regulation of gene expression PubMed 
Items 1 - 25 of 40
Component Evidence Code Pubs
located_in extracellular region  
is_active_in extracellular space  
located_in extracellular space PubMed 
located_in extracellular space  
part_of granulocyte macrophage colony-stimulating factor receptor complex  
part_of granulocyte macrophage colony-stimulating factor receptor complex  
located_in intracellular membrane-bounded organelle  
located_in intracellular membrane-bounded organelle  

General protein information

Preferred Names
granulocyte-macrophage colony-stimulating factor
Names
colony-stimulating factor
granulocyte-macrophage colony stimulating factor 2
put. GM-CSF

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009969.4NP_034099.2  granulocyte-macrophage colony-stimulating factor precursor

    See identical proteins and their annotated locations for NP_034099.2

    Status: VALIDATED

    Source sequence(s)
    AL596103
    Consensus CDS
    CCDS24692.1
    UniProtKB/Swiss-Prot
    P01587
    UniProtKB/TrEMBL
    Q14AD9, Q5SX78
    Related
    ENSMUSP00000019060.6, ENSMUST00000019060.6
    Conserved Domains (1) summary
    smart00040
    Location:18135
    CSF2; Granulocyte-macrophage colony-simulating factor (GM-CSF)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    54138096..54140725 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532127.4XP_006532190.1  granulocyte-macrophage colony-stimulating factor isoform X1

    Conserved Domains (1) summary
    cl23816
    Location:1990
    CSF2; Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) is a member of the large family of polypeptide growth factors called cytokines. It stimulates a wide variety of hematopoietic and nonhematopoietic cell types via binding to members of the cytokine ...
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