Crhr2 corticotropin releasing hormone receptor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Crhr2provided by MGI
Official Full Name: corticotropin releasing hormone receptor 2provided by MGI
Primary source: MGI:MGI:894312
See related: Ensembl:ENSMUSG00000003476 AllianceGenome:MGI:894312
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Crfr2; CRF-R2; CRFR2beta; CRFR2alpha
Summary: Enables corticotrophin-releasing factor receptor activity and hormone activity. Acts upstream of or within G protein-coupled receptor signaling pathway; negative regulation of angiogenesis; and regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway. Located in Golgi apparatus; cell surface; and endoplasmic reticulum. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and integumental system. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CRHR2 (corticotropin releasing hormone receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in heart adult (RPKM 14.2), mammary gland adult (RPKM 3.1) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 B3; 6 27.33 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (55067033..55110001, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (55090048..55133016, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Basolateral amygdala corticotropin releasing factor receptor 2 interacts with nonmuscle myosin II to destabilize memory in males.
Title: Basolateral amygdala corticotropin releasing factor receptor 2 interacts with nonmuscle myosin II to destabilize memory in males.
CRH-R2 signalling modulates feeding and circadian gene expression in hypothalamic mHypoA-2/30 neurons.
Title: CRH-R2 signalling modulates feeding and circadian gene expression in hypothalamic mHypoA-2/30 neurons.
Chronic UCN2 treatment desensitizes CRHR2 and improves insulin sensitivity.
Title: Chronic UCN2 treatment desensitizes CRHR2 and improves insulin sensitivity.
Corticotropin-releasing factor receptor type 2 in the midbrain critically contributes to the hedonic feeding behavior of mice under heat stress.
Title: Corticotropin-releasing factor receptor type 2 in the midbrain critically contributes to the hedonic feeding behavior of mice under heat stress.
Expression Patterns of the Neuropeptide Urocortin 3 and Its Receptor CRFR2 in the Mouse Central Auditory System.
Title: Expression Patterns of the Neuropeptide Urocortin 3 and Its Receptor CRFR2 in the Mouse Central Auditory System.
Spexin as an anxiety regulator in mouse hippocampus: Mechanisms for transcriptional regulation of spexin gene expression by corticotropin releasing factor.
Title: Spexin as an anxiety regulator in mouse hippocampus: Mechanisms for transcriptional regulation of spexin gene expression by corticotropin releasing factor.
this study shows that mast cell corticotropin-releasing factor subtype 2 suppresses mast cell degranulation and limits the severity of anaphylaxis and stress-induced intestinal permeability
Title: Mast cell corticotropin-releasing factor subtype 2 suppresses mast cell degranulation and limits the severity of anaphylaxis and stress-induced intestinal permeability.
plasma extracellular vesicles from immune cells carry CRFRs as cargos and influence cell-cell communication in health and disease.
Title: Plasma Corticotropin-Releasing Factor Receptors and B7-2⁺ Extracellular Vesicles in Blood Correlate with Irritable Bowel Syndrome Disease Severity.
results show that in response to MS, CRHR1 mediates gut injury by promoting intestinal inflammation, increasing gut permeability, altering intestinal morphology, and modulating the intestinal microbiota. In contrast, CRHR2 activates intestinal stem cells and is important for gut repair.
Title: Inhibition of corticotropin-releasing hormone receptor 1 and activation of receptor 2 protect against colonic injury and promote epithelium repair.
In this study, mild blast-induced traumatic brain injury (mbTBI) did not alter CRFR1 gene expression in males or females. However, mbTBI disrupted CRFR2 gene expression in different limbic structures in males and females.
Title: Sex-Dependent Effects of Mild Blast-induced Traumatic Brain Injury on Corticotropin-releasing Factor Receptor Gene Expression: Potential Link to Anxiety-like Behaviors.

Submit: New GeneRIF Correction See all GeneRIFs (84)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Crhr2 (e-PCR), detects polymorphism
- UniSTS:141397

Crhr2 (e-PCR), detects polymorphism
- UniSTS:141398

CRHR2 (e-PCR)
- UniSTS:510380

Crhr2 (e-PCR), detects polymorphism
- UniSTS:507861

Crhr2 (e-PCR), detects polymorphism
- UniSTS:507862

Crhr2 (e-PCR), detects polymorphism
- UniSTS:507863

Crhr2 (e-PCR), detects polymorphism
- UniSTS:507864

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables corticotrophin-releasing factor receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables corticotrophin-releasing factor receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables corticotropin-releasing hormone receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables corticotropin-releasing hormone receptor activity	ISO Inferred from Sequence Orthology more info
enables hormone activity	IDA Inferred from Direct Assay more info	PubMed
enables peptide hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in actin filament organization	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in catecholamine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in gastric motility	ISO Inferred from Sequence Orthology more info
involved_in long-term synaptic potentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of calcium ion import	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of defecation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epinephrine secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of feeding behavior	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of follicle-stimulating hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of luteinizing hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of norepinephrine secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cAMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of serotonin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress-activated MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in protein kinase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in skeletal muscle tissue growth	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
is_active_in axon terminus	IBA Inferred from Biological aspect of Ancestor more info
located_in axon terminus	ISO Inferred from Sequence Orthology more info
located_in cell body fiber	ISO Inferred from Sequence Orthology more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in varicosity	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: corticotropin-releasing factor receptor 2

Names: CRF 2 receptor; CRF-R-2; CRF-RB; CRFR-2; CRH-R-2; CRH-R2; corticotropin releasing factor receptor type 2 beta; corticotropin-releasing factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001288618.1 → NP_001275547.1 corticotropin-releasing factor receptor 2 isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK085854, AK142261, CJ065172

Consensus CDS

CCDS85053.1

UniProtKB/TrEMBL

A0A1D5RLK7, E9PXI8

Related

ENSMUSP00000148408.2, ENSMUST00000212633.2

Conserved Domains (2) summary

smart00008
Location:56 → 127

HormR; Domain present in hormone receptors

pfam00002
Location:133 → 375

7tm_2; 7 transmembrane receptor (Secretin family)
NM_001288619.1 → NP_001275548.1 corticotropin-releasing factor receptor 2 isoform 3 precursor

See identical proteins and their annotated locations for NP_001275548.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AK142261, AY445512

Consensus CDS

CCDS85052.1

UniProtKB/Swiss-Prot

B9EHB5, Q5GL24, Q60748, Q60783, Q60808

Related

ENSMUSP00000148297.2, ENSMUST00000213026.2

Conserved Domains (2) summary

smart00008
Location:36 → 107

HormR; Domain present in hormone receptors

pfam00002
Location:113 → 355

7tm_2; 7 transmembrane receptor (Secretin family)
NM_001288620.1 → NP_001275549.1 corticotropin-releasing factor receptor 2 isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and lacks an alternate coding exon compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AK142261, AY753668

UniProtKB/TrEMBL

Q3UQP0, Q5ERJ2

Conserved Domains (1) summary

pfam00002
Location:37 → 250

7tm_2; 7 transmembrane receptor (Secretin family)
NM_009953.4 → NP_034083.2 corticotropin-releasing factor receptor 2 isoform 2 precursor

See identical proteins and their annotated locations for NP_034083.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but lacks an alternate internal aa compared to isoform 1.

Source sequence(s)

AK085854, AK142261

Consensus CDS

CCDS20162.1

UniProtKB/TrEMBL

E9PXI8, Q3UQP0

Related

ENSMUSP00000003568.9, ENSMUST00000003568.15

Conserved Domains (2) summary

smart00008
Location:56 → 127

HormR; Domain present in hormone receptors

pfam00002
Location:132 → 374

7tm_2; 7 transmembrane receptor (Secretin family)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

55067033..55110001 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006505482.4 → XP_006505545.1 corticotropin-releasing factor receptor 2 isoform X1

UniProtKB/TrEMBL

E9QNK5

Related

ENSMUSP00000110015.3, ENSMUST00000114374.9

Conserved Domains (3) summary

smart00008
Location:36 → 107

HormR; Domain present in hormone receptors

cd14964
Location:114 → 139

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:112 → 375

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily