Atf6b activating transcription factor 6 beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Atf6bprovided by MGI
Official Full Name: activating transcription factor 6 betaprovided by MGI
Primary source: MGI:MGI:105121
See related: Ensembl:ENSMUSG00000015461 AllianceGenome:MGI:105121
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Crebl1; Creb-rp; ATF6beta
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to contribute to DNA-binding transcription activator activity, RNA polymerase II-specific. Predicted to be involved in endoplasmic reticulum unfolded protein response; negative regulation of ATF6-mediated unfolded protein response; and positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress. Predicted to act upstream of or within response to unfolded protein. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of RNA polymerase II transcription regulator complex and protein-DNA complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human ATF6B (activating transcription factor 6 beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 51.3), adrenal adult (RPKM 50.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 18.22 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (34866120..34874048)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (34647146..34655074)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Partial limitation of cellular functions and compensatory modulation of unfolded protein response pathways caused by double-knockout of ATF6alpha and ATF6beta.
Title: Partial limitation of cellular functions and compensatory modulation of unfolded protein response pathways caused by double-knockout of ATF6α and ATF6β.
ATF6beta Deficiency Elicits Anxiety-like Behavior and Hyperactivity Under Stress Conditions.
Title: ATF6β Deficiency Elicits Anxiety-like Behavior and Hyperactivity Under Stress Conditions.
The ATF6beta-calreticulin axis promotes neuronal survival under endoplasmic reticulum stress and excitotoxicity.
Title: The ATF6β-calreticulin axis promotes neuronal survival under endoplasmic reticulum stress and excitotoxicity.
Overlapping and differential functions of ATF6alpha versus ATF6beta in the mouse heart.
Title: Overlapping and differential functions of ATF6α versus ATF6β in the mouse heart.
Metaphyseal chondrodysplasia Schmid type disease severity in mice is increased by ATF6alpha ablation and decreased by ATF6beta ablation triggered by mutations in collagen X.
Title: Paradoxical roles of ATF6α and ATF6β in modulating disease severity caused by mutations in collagen X.
Toxoplasma virulence factor ROP18 inactivates host innate and adaptive immune responses by targeting ATF6beta.
Title: Inhibition of ATF6β-dependent host adaptive immune response by a Toxoplasma virulence factor ROP18.
interference with ATF6beta-dependent immune responses is a novel pathogenic mechanism induced by ROP18
Title: ATF6beta is a host cellular target of the Toxoplasma gondii virulence factor ROP18.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:237630 (e-PCR)
- UniSTS:237630

D17884 (e-PCR)
- UniSTS:124736

RH124526 (e-PCR)
- UniSTS:161348

Atf6b (e-PCR), detects polymorphism
- UniSTS:547187

BB365118 (e-PCR)
- UniSTS:209297

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
contributes_to DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in endoplasmic reticulum unfolded protein response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of ATF6-mediated unfolded protein response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to unfolded protein	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	NAS Non-traceable Author Statement more info	PubMed
located_in intracellular anatomical structure	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed
part_of protein-DNA complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cyclic AMP-dependent transcription factor ATF-6 beta

Names: ATF6-beta; cAMP response element binding protein-related protein; cAMP-dependent transcription factor ATF-6 beta; cAMP-responsive element-binding protein-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017406.4 → NP_059102.2 cyclic AMP-dependent transcription factor ATF-6 beta

Status: VALIDATED

Source sequence(s)

AK146671, BP766726, CT009767

Consensus CDS

CCDS28655.2

UniProtKB/TrEMBL

A0A0A0MQ69, G3UX19

Related

ENSMUSP00000015605.10, ENSMUST00000015605.15

Conserved Domains (1) summary

cd14700
Location:332 → 383

bZIP_ATF6; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-6 (ATF-6) and similar proteins: a DNA-binding and dimerization domain