Crabp2 cellular retinoic acid binding protein II [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Crabp2provided by MGI
Official Full Name: cellular retinoic acid binding protein IIprovided by MGI
Primary source: MGI:MGI:88491
See related: Ensembl:ENSMUSG00000004885 AllianceGenome:MGI:88491
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Crabp-2; CrabpII
Summary: Enables retinoic acid binding activity. Acts upstream of or within embryonic forelimb morphogenesis; positive regulation of collateral sprouting; and retinoic acid metabolic process. Located in endoplasmic reticulum and nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; heart and pericardium; and sensory organ. Orthologous to human CRABP2 (cellular retinoic acid binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E11.5 (RPKM 125.3), limb E14.5 (RPKM 55.3) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 38.78 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (87856000..87860679)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (87948693..87953372)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Crabp2 Promotes Metastasis of Lung Cancer Cells via HuR and Integrin beta1/FAK/ERK Signaling.
Title: Crabp2 Promotes Metastasis of Lung Cancer Cells via HuR and Integrin β1/FAK/ERK Signaling.
In a study of mice and human skin, data strongly supports the hypothesis that a reduction of CRABP-II expression accelerates and promotes skin aging, and suggests CRABP-II as a novel target to improve the efficacy of retinoid-mediated antiaging therapies.
Title: Cellular retinoic acid binding protein-II expression and its potential role in skin aging.
The anticarcinogenic activities of CRABP2 are mediated by both HuR and RAR.
Title: Cellular retinoic acid-binding protein 2 inhibits tumor growth by two distinct mechanisms.
Results show that acetylation status of CRABPII directly influences embryonic stem cell differentiation in response to retinoic acid.
Title: SIRT1-mediated deacetylation of CRABPII regulates cellular retinoic acid signaling and modulates embryonic stem cell differentiation.
CRABP2 controls mRNA stabilization by HuR.
Title: Transcript stabilization by the RNA-binding protein HuR is regulated by cellular retinoic acid-binding protein 2.
all three proteins (RDH10, RALDH2, and CRABP2) appeared to be required for ATRA production induced by activation of PPARgamma
Title: RDH10, RALDH2, and CRABP2 are required components of PPARγ-directed ATRA synthesis and signaling in human dendritic cells.
CRABP2 promotes myoblast differentiation and is modulated by the transcription factors MyoD and Sp1 in C2C12 cells.
Title: CRABP2 promotes myoblast differentiation and is modulated by the transcription factors MyoD and Sp1 in C2C12 cells.
observations emphasize the important role of CRABP-II in regulating the transcriptional activity of RA through RAR, and they demonstrate that repression of this gene is critical for allowing adipogenesis to proceed
Title: Repression of cellular retinoic acid-binding protein II during adipocyte differentiation.
TIS7 inhibits CRABP II expression during axonal regeneration, thereby modulating retinoic acid signalling. Hence, neurite initiation and branching are regulated by a negative feedback mechanism involving TIS7 and CRABP II.
Title: The transcriptional corepressor TPA-inducible sequence 7 regulates adult axon growth through cellular retinoic acid binding protein II expression.
Increases in CRABPI and II transcripts in the absence of leukemia inhibitory factor may regulate aspects of embryonic stem cell differentiation in response to retinol.
Title: LIF removal increases CRABPI and CRABPII transcripts in embryonic stem cells cultured in retinol or 4-oxoretinol.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (3)

General gene information

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Markers

Crabp2 (e-PCR), detects polymorphism
- UniSTS:547434

AI893628 (e-PCR)
- UniSTS:165260

Crabp2 (e-PCR), detects polymorphism
- UniSTS:186508

Crabp2 (e-PCR), detects polymorphism
- UniSTS:525480

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cyclin binding	ISO Inferred from Sequence Orthology more info
enables fatty acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables retinal binding	IEA Inferred from Electronic Annotation more info
enables retinoic acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables retinoic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables retinoic acid binding	ISO Inferred from Sequence Orthology more info
enables retinol binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within embryonic forelimb morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of collateral sprouting	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within retinoic acid metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cellular retinoic acid-binding protein 2

Names: CRABP-II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007759.2 → NP_031785.1 cellular retinoic acid-binding protein 2

See identical proteins and their annotated locations for NP_031785.1

Status: PROVISIONAL

Source sequence(s)

AC158233

Consensus CDS

CCDS17460.1

UniProtKB/Swiss-Prot

P22935

Related

ENSMUSP00000005019.6, ENSMUST00000005019.6

Conserved Domains (1) summary

cl10502
Location:3 → 138

lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family