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Cox5a cytochrome c oxidase subunit 5A [ Mus musculus (house mouse) ]

Gene ID: 12858, updated on 11-Apr-2024

Summary

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Official Symbol
Cox5aprovided by MGI
Official Full Name
cytochrome c oxidase subunit 5Aprovided by MGI
Primary source
MGI:MGI:88474
See related
Ensembl:ENSMUSG00000000088 AllianceGenome:MGI:88474
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CcOX
Summary
Predicted to enable cytochrome-c oxidase activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Located in mitochondrion. Part of mitochondrial respiratory chain complex IV. Is expressed in several structures, including alimentary system; hindlimb musculature; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease. Orthologous to human COX5A (cytochrome c oxidase subunit 5A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in duodenum adult (RPKM 1236.7), stomach adult (RPKM 854.8) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 B; 9 31.05 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (57423012..57439710)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (57517328..57532427)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51707 Neighboring gene STARR-seq mESC enhancer starr_24237 Neighboring gene STARR-seq mESC enhancer starr_24239 Neighboring gene ribonuclease P/MRP 25 subunit Neighboring gene STARR-positive B cell enhancer ABC_E11408 Neighboring gene family with sequence similarity 219, member B Neighboring gene mannose phosphate isomerase Neighboring gene STARR-positive B cell enhancer ABC_E3834 Neighboring gene STARR-positive B cell enhancer ABC_E3835 Neighboring gene secretory carrier membrane protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deficits in hippocampal CA1 LTP induced by TBS but not HFS in the Ts65Dn mouse: a model of Down syndrome. Costa AC, et al. Neurosci Lett, 2005 Jul 15. PMID 15925111
  2. Protein kinase A-mediated phosphorylation modulates cytochrome c oxidase function and augments hypoxia and myocardial ischemia-related injury. Prabu SK, et al. J Biol Chem, 2006 Jan 27. PMID 16303765, Free PMC Article
  3. Mitochondrial type I nitric oxide synthase physically interacts with cytochrome c oxidase. Persichini T, et al. Neurosci Lett, 2005 Aug 26. PMID 15923083
  4. Amino acid replacement is rapid in primates for the mature polypeptides of COX subunits, but not for their targeting presequences. Schmidt TR, et al. Gene, 2002 Mar 6. PMID 11943455
  5. Isolation and sequence of the structural gene for cytochrome c oxidase subunit VI from Saccharomyces cerevisiae. Wright RM, et al. J Biol Chem, 1984 Dec 25. PMID 6210289

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SCN2B could play an important role in the aging-related cognitive deterioration, which is associated with the regulations of COX5A and FGF-2.
    Title: Sodium Channel Voltage-Gated Beta 2 Plays a Vital Role in Brain Aging Associated with Synaptic Plasticity and Expression of COX5A and FGF-2.
  2. gene expression of the Cox subunits, Cox5a, 5b, and 6b1 is not required for embryo developmental events up to the blastocyst stage
    Title: Gene expression of cox5a, 5b, or 6b1 and their roles in preimplantation mouse embryos.
  3. Protein kinase A-mediated phosphorylation modulates cytochrome c oxidase function and augments hypoxia and myocardial ischemia-related injury
    Title: Protein kinase A-mediated phosphorylation modulates cytochrome c oxidase function and augments hypoxia and myocardial ischemia-related injury.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytochrome-c oxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial respiratory chain complex IV IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial respiratory chain complex IV IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mitochondrial respiratory chain complex IV ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in myelin sheath HDA PubMed 

General protein information

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Preferred Names
cytochrome c oxidase subunit 5A, mitochondrial
Names
cytochrome c oxidase polypeptide Va
cytochrome c oxidase subunit Va
NP_031773.2
XP_030099894.1
XP_036010484.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007747.2 → NP_031773.2  cytochrome c oxidase subunit 5A, mitochondrial precursor

    See identical proteins and their annotated locations for NP_031773.2

    Status: VALIDATED

    Source sequence(s)
    AK018723, BY259203, CO044753
    Consensus CDS
    CCDS23223.1
    UniProtKB/Swiss-Prot
    P12787, Q9D2W1
    Related
    ENSMUSP00000000090.7, ENSMUST00000000090.8
    Conserved Domains (1) summary
    cd00923
    Location:41 → 142
    Cyt_c_Oxidase_Va; Cytochrome c oxidase subunit Va. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    57423012..57439710
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244034.2 → XP_030099894.1  cytochrome c oxidase subunit 5A, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    P12787, Q9D2W1
    Conserved Domains (1) summary
    cd00923
    Location:41 → 142
    Cyt_c_Oxidase_Va; Cytochrome c oxidase subunit Va. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

  2. XM_036154591.1 → XP_036010484.1  cytochrome c oxidase subunit 5A, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    P12787, Q9D2W1
    Conserved Domains (1) summary
    cd00923
    Location:41 → 142
    Cyt_c_Oxidase_Va; Cytochrome c oxidase subunit Va. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P12787.2 GenPept UniProtKB/Swiss-Prot:P12787

Gene LinkOut

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