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Cish cytokine inducible SH2-containing protein [ Mus musculus (house mouse) ]

Gene ID: 12700, updated on 5-Mar-2024

Summary

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Official Symbol
Cishprovided by MGI
Official Full Name
cytokine inducible SH2-containing proteinprovided by MGI
Primary source
MGI:MGI:103159
See related
Ensembl:ENSMUSG00000032578 AllianceGenome:MGI:103159
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cis; F17; F23; CIS1; SOCS; CIS-1
Summary
Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity. Acts upstream of or within protein kinase C-activating G protein-coupled receptor signaling pathway. Located in plasma membrane. Is expressed in liver; retina; and thymus primordium. Human ortholog(s) of this gene implicated in malaria and tuberculosis. Orthologous to human CISH (cytokine inducible SH2 containing protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart adult (RPKM 25.8), lung adult (RPKM 20.1) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 F1; 9 57.99 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (107173858..107179983)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (107296659..107302784)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase-activated protein kinase 3 Neighboring gene STARR-seq mESC enhancer starr_25168 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:107192213-107192396 Neighboring gene STARR-positive B cell enhancer mm9_chr9:107198795-107199096 Neighboring gene predicted gene 17040 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:107215338-107215525 Neighboring gene STARR-seq mESC enhancer starr_25171 Neighboring gene HemK methyltransferase family member 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:107240678-107240861 Neighboring gene RIKEN cDNA 6430571L13 gene Neighboring gene STARR-positive B cell enhancer ABC_E6801 Neighboring gene RIKEN cDNA 4930429P21 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Targeting CISH enhances natural cytotoxicity receptor signaling and reduces NK cell exhaustion to improve solid tumor immunity. Bernard PL, et al. J Immunother Cancer, 2022 May. PMID 35589278, Free PMC Article
  2. Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance. Palmer DC, et al. J Exp Med, 2015 Nov 16. PMID 26527801, Free PMC Article
  3. CISH is induced during DC development and regulates DC-mediated CTL activation. Miah MA, et al. Eur J Immunol, 2012 Jan. PMID 22002016
  4. Suppression of STAT5 functions in liver, mammary glands, and T cells in cytokine-inducible SH2-containing protein 1 transgenic mice. Matsumoto A, et al. Mol Cell Biol, 1999 Sep. PMID 10454585, Free PMC Article
  5. CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation. Matsumoto A, et al. Blood, 1997 May 1. PMID 9129017

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Role of Cytokine-Inducible SH2 Domain-Containing (CISH) Protein in the Regulation of Erythropoiesis.
    Title: Role of Cytokine-Inducible SH2 Domain-Containing (CISH) Protein in the Regulation of Erythropoiesis.
  2. The Role of Cytokine-Inducible SH2 Domain-Containing Protein (CISH) in the Regulation of Basal and Cytokine-Mediated Myelopoiesis.
    Title: The Role of Cytokine-Inducible SH2 Domain-Containing Protein (CISH) in the Regulation of Basal and Cytokine-Mediated Myelopoiesis.
  3. Hepatic cytokine-inducible SH2-containing protein (CISH) regulates gluconeogenesis via cAMP-responsive element binding protein (CREB).
    Title: Hepatic cytokine-inducible SH2-containing protein (CISH) regulates gluconeogenesis via cAMP-responsive element binding protein (CREB).
  4. Targeting CISH enhances natural cytotoxicity receptor signaling and reduces NK cell exhaustion to improve solid tumor immunity.
    Title: Targeting CISH enhances natural cytotoxicity receptor signaling and reduces NK cell exhaustion to improve solid tumor immunity.
  5. Cytokine-inducible SH2 domain containing protein contributes to regulation of adiposity, food intake, and glucose metabolism.
    Title: Cytokine-inducible SH2 domain containing protein contributes to regulation of adiposity, food intake, and glucose metabolism.
  6. CISH constrains the tuft-ILC2 circuit to set epithelial and immune tone.
    Title: CISH constrains the tuft-ILC2 circuit to set epithelial and immune tone.
  7. NK Cell Priming From Endogenous Homeostatic Signals Is Modulated by CIS.
    Title: NK Cell Priming From Endogenous Homeostatic Signals Is Modulated by CIS.
  8. NK cell-derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS.
    Title: NK cell-derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS.
  9. Socs3 and Cish inversely regulated (increased and decreased, respectively) by bromodomain and extraterminal protein inhibition
    Title: Bromodomain and Extraterminal Inhibition by JQ1 Produces Divergent Transcriptional Regulation of Suppressors of Cytokine Signaling Genes in Adipocytes.
  10. We conclude that the Cish-SH2 domain is essential for PLC-gamma1 regulation in TCR-stimulated CD8(+) T cells.
    Title: The Cish SH2 domain is essential for PLC-γ1 regulation in TCR stimulated CD8(+) T cells.
Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (8)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein kinase C-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of phosphatidylinositol 3-kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cytokine-inducible SH2-containing protein
Names
cytokine-inducible SH2 protein
suppressor of cytokine signaling

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317354.1 → NP_001304283.1  cytokine-inducible SH2-containing protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region, resulting in a distinct 5' UTR, and translation initiation from a down stream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK077338, AK086040, AL672070
    UniProtKB/TrEMBL
    Q8C3F4
    Conserved Domains (2) summary
    cl02533
    Location:119 → 159
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    cl15255
    Location:1 → 66
    SH2; Src homology 2 (SH2) domain

  2. NM_009895.4 → NP_034025.1  cytokine-inducible SH2-containing protein isoform 1

    See identical proteins and their annotated locations for NP_034025.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK077338, AK086040, AL672070
    Consensus CDS
    CCDS40761.1
    UniProtKB/Swiss-Prot
    Q3TC70, Q62225
    Related
    ENSMUSP00000082183.6, ENSMUST00000085102.6
    Conserved Domains (2) summary
    cd10718
    Location:77 → 164
    SH2_CIS; Src homology 2 (SH2) domain found in cytokine-inducible SH2-containing protein (CIS)
    cd03734
    Location:217 → 257
    SOCS_CIS1; SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like proteins. Together with the SOCS proteins, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    107173858..107179983
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511635.3 → XP_006511698.1  cytokine-inducible SH2-containing protein isoform X1

    Conserved Domains (2) summary
    cd10718
    Location:145 → 232
    SH2_CIS; Src homology 2 (SH2) domain found in cytokine-inducible SH2-containing protein (CIS)
    cd03734
    Location:285 → 325
    SOCS_CIS1; SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like proteins. Together with the SOCS proteins, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62225.1 GenPept UniProtKB/Swiss-Prot:Q62225

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