Cfl1 cofilin 1, non-muscle [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cfl1provided by MGI
Official Full Name: cofilin 1, non-muscleprovided by MGI
Primary source: MGI:MGI:101757
See related: Ensembl:ENSMUSG00000056201 AllianceGenome:MGI:101757
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cof
Summary: Enables actin filament binding activity and signaling receptor binding activity. Involved in cytoskeleton organization; positive regulation of actin filament depolymerization; and positive regulation of embryonic development. Acts upstream of or within several processes, including neural crest cell migration; neural fold formation; and response to amino acid. Located in cell-cell junction; cortical actin cytoskeleton; and lamellipodium. Is expressed in several structures, including central nervous system; early conceptus; embryo mesenchyme; genitourinary system; and immune system. Orthologous to human CFL1 (cofilin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E18 (RPKM 655.5), CNS E11.5 (RPKM 635.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 4.34 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (5540483..5544059)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (5490455..5494031)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cofilin 1 Is Dynamically Modulated During Postnatal Development and by Visual Input in the Mouse Visual Cortex.
Title: Cofilin 1 Is Dynamically Modulated During Postnatal Development and by Visual Input in the Mouse Visual Cortex.
Huntingtin coordinates dendritic spine morphology and function through cofilin-mediated control of the actin cytoskeleton.
Title: Huntingtin coordinates dendritic spine morphology and function through cofilin-mediated control of the actin cytoskeleton.
The early molecular events leading to COFILIN phosphorylation during mouse sperm capacitation are essential for acrosomal exocytosis.
Title: The early molecular events leading to COFILIN phosphorylation during mouse sperm capacitation are essential for acrosomal exocytosis.
The effect of cofilin 1 expression and phosphorylation dynamics on cell fate determination and neuron maturation in neural stem cells.
Title: The effect of cofilin 1 expression and phosphorylation dynamics on cell fate determination and neuron maturation in neural stem cells.
The non-muscle ADF/cofilin-1 controls sarcomeric actin filament integrity and force production in striated muscle laminopathies.
Title: The non-muscle ADF/cofilin-1 controls sarcomeric actin filament integrity and force production in striated muscle laminopathies.
ABL1 and Cofilin1 promote T-cell acute lymphoblastic leukemia cell migration.
Title: ABL1 and Cofilin1 promote T-cell acute lymphoblastic leukemia cell migration.
Cofilin1 oxidation links oxidative distress to mitochondrial demise and neuronal cell death.
Title: Cofilin1 oxidation links oxidative distress to mitochondrial demise and neuronal cell death.
Actin at stereocilia tips is regulated by mechanotransduction and ADF/cofilin.
Title: Actin at stereocilia tips is regulated by mechanotransduction and ADF/cofilin.
hnRNP Q and hnRNP A1 Regulate the Translation of Cofilin in Response to Transient Oxygen-Glucose Deprivation in Hippocampal Neurons.
Title: hnRNP Q and hnRNP A1 Regulate the Translation of Cofilin in Response to Transient Oxygen-Glucose Deprivation in Hippocampal Neurons.
Infantile spasms-linked Nedd4-2 mediates hippocampal plasticity and learning via cofilin signaling.
Title: Infantile spasms-linked Nedd4-2 mediates hippocampal plasticity and learning via cofilin signaling.

Submit: New GeneRIF Correction See all GeneRIFs (73)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (6) 1 citation
Chemically induced (ENU) (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cfl1 (e-PCR), detects polymorphism
- UniSTS:141326

Cfl1 (e-PCR), detects polymorphism
- UniSTS:527286

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament depolymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in actin filament depolymerization	ISO Inferred from Sequence Orthology more info
involved_in actin filament fragmentation	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament fragmentation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament severing	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell motility	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell projection organization	ISO Inferred from Sequence Orthology more info	PubMed
involved_in cellular response to epidermal growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin-like growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interleukin-1	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interleukin-6	ISO Inferred from Sequence Orthology more info
involved_in cellular response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in cytoskeleton organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of spindle localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modification of postsynaptic actin cytoskeleton	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of actin filament depolymerization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell motility	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell size	ISO Inferred from Sequence Orthology more info	PubMed
involved_in negative regulation of dendritic spine maintenance	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of postsynaptic density organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of unidimensional cell growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural crest cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural fold formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation by host of viral process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of actin filament depolymerization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of actin filament depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of barbed-end actin filament capping	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell motility	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic spine development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of establishment of cell polarity regulating cell shape	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to cell leading edge	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteolysis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in protein import into nucleus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to amino acid	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cofilin-actin rod	ISO Inferred from Sequence Orthology more info
located_in cortical actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	TAS Traceable Author Statement more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in filopodium	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
is_active_in lamellipodium	IBA Inferred from Biological aspect of Ancestor more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density, intracellular component	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cofilin-1

Names: n-cofilin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.