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Cdkn1c cyclin dependent kinase inhibitor 1C [ Mus musculus (house mouse) ]

Gene ID: 12577, updated on 22-Apr-2024

Summary

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Official Symbol
Cdkn1cprovided by MGI
Official Full Name
cyclin dependent kinase inhibitor 1Cprovided by MGI
Primary source
MGI:MGI:104564
See related
Ensembl:ENSMUSG00000037664 AllianceGenome:MGI:104564
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CDKI; Kip2; p57Kip2; p57(kip2)
Summary
Predicted to enable protein kinase inhibitor activity. Involved in negative regulation of phosphorylation. Acts upstream of or within several processes, including animal organ development; genetic imprinting; and regulation of exit from mitosis. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; extraembryonic component; genitourinary system; and sensory organ. Used to study Beckwith-Wiedemann syndrome and pre-eclampsia. Human ortholog(s) of this gene implicated in Beckwith-Wiedemann syndrome; IMAGe syndrome; and hyperinsulinism. Orthologous to human CDKN1C (cyclin dependent kinase inhibitor 1C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in limb E14.5 (RPKM 280.3), adrenal adult (RPKM 244.3) and 10 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 F5; 7 88.22 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (143012076..143014735, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (143458339..143461059, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel, subfamily Q, member 1 Neighboring gene KCNQ1 overlapping transcript 1 Neighboring gene STARR-positive B cell enhancer ABC_E10485 Neighboring gene RIKEN cDNA 4933417O13 gene Neighboring gene STARR-seq mESC enhancer starr_20528 Neighboring gene STARR-seq mESC enhancer starr_20529 Neighboring gene STARR-seq mESC enhancer starr_20530 Neighboring gene predicted gene, 33663 Neighboring gene solute carrier family 22 (organic cation transporter), member 18

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Methylation of Cdkn1c may be involved in the regulation of tooth development through cell cycle inhibition. Li Q, et al. J Mol Histol, 2018 Oct. PMID 30014245, Free PMC Article
  2. Dopaminergic and behavioural changes in a loss-of-imprinting model of Cdkn1c. McNamara GI, et al. Genes Brain Behav, 2018 Feb. PMID 28857482, Free PMC Article
  3. Global increase in replication fork speed during a p57(KIP2)-regulated erythroid cell fate switch. Hwang Y, et al. Sci Adv, 2017 May. PMID 28560351, Free PMC Article
  4. A p57 conditional mutant allele that allows tracking of p57-expressing cells. Mademtzoglou D, et al. Genesis, 2017 Apr. PMID 28196404
  5. Visualizing Changes in Cdkn1c Expression Links Early-Life Adversity to Imprint Mis-regulation in Adults. Van de Pette M, et al. Cell Rep, 2017 Jan 31. PMID 28147266, Free PMC Article

See all (412) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Protein restriction during pregnancy alters Cdkn1c silencing, dopamine circuitry and offspring behaviour without changing expression of key neuronal marker genes.
    Title: Protein restriction during pregnancy alters Cdkn1c silencing, dopamine circuitry and offspring behaviour without changing expression of key neuronal marker genes.
  2. Epigenetic control of the imprinted growth regulator Cdkn1c in cadmium-induced placental dysfunction.
    Title: Epigenetic control of the imprinted growth regulator Cdkn1c in cadmium-induced placental dysfunction.
  3. p57[Kip2] acts as a transcriptional corepressor to regulate intestinal stem cell fate and proliferation.
    Title: p57(Kip2) acts as a transcriptional corepressor to regulate intestinal stem cell fate and proliferation.
  4. p57Kip2 is an essential regulator of vitamin D receptor-dependent mechanisms.
    Title: p57Kip2 is an essential regulator of vitamin D receptor-dependent mechanisms.
  5. IGF2 interacts with the imprinted gene Cdkn1c to promote terminal differentiation of neural stem cells.
    Title: IGF2 interacts with the imprinted gene Cdkn1c to promote terminal differentiation of neural stem cells.
  6. p57(Kip2) imposes the reserve stem cell state of gastric chief cells.
    Title: p57(Kip2) imposes the reserve stem cell state of gastric chief cells.
  7. Role of the imprinted allele of the Cdkn1c gene in mouse neocortical development.
    Title: Role of the imprinted allele of the Cdkn1c gene in mouse neocortical development.
  8. Cdkn1c locus regulates cortical development through distinct cell-autonomous and non-cell-autonomous mechanisms.
    Title: Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development.
  9. The results reveal a novel Shh-Foxd1-Cdkn1c regulatory circuit that drives the mitogenic action of Shh signaling. Shh pathway activation of Foxd1 is followed by downregulation of Cdkn1c, which encodes a cyclin-dependent kinase inhibitor.
    Title: Coordinated d-cyclin/Foxd1 activation drives mitogenic activity of the Sonic Hedgehog signaling pathway.
  10. Here we show that loss of Ezh2 resulted in altered expression of several key cyclin-dependent kinase inhibitors including Cdkn2a (p16 and Arf) and Cdkn1c (p57) in naive CD8+ T cells after activation, which explained the cell cycle impairment of Ezh2-deficient naive CD8+ T cells in response to antigenic stimulation.
    Title: Ezh2 Regulates Activation-Induced CD8(+) T Cell Cycle Progression via Repressing Cdkn2a and Cdkn1c Expression.
Submit: New GeneRIF Correction See all GeneRIFs (66)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular function inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within adrenal gland development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within camera-type eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within digestive system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryonic placenta morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within genomic imprinting IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within myeloid cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cyclin-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within neuron maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within placenta development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within placenta development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of exit from mitosis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of lens fiber cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within skeletal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within uterus development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cyclin-dependent kinase inhibitor 1C
Names
cyclin dependent kinase inhibitor 1C (P57)
cyclin-dependent kinase inhibitor p57

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161624.2 → NP_001155096.1  cyclin-dependent kinase inhibitor 1C isoform 1

    See identical proteins and their annotated locations for NP_001155096.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC023248
    Consensus CDS
    CCDS52463.1
    UniProtKB/Swiss-Prot
    G3UW61, P49919
    UniProtKB/TrEMBL
    Q8BP34
    Related
    ENSMUSP00000128828.2, ENSMUST00000167912.9
    Conserved Domains (2) summary
    PTZ00341
    Location:197 → 281
    PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
    pfam02234
    Location:34 → 81
    CDI; Cyclin-dependent kinase inhibitor

  2. NM_001354981.2 → NP_001341910.1  cyclin-dependent kinase inhibitor 1C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC023248
    Consensus CDS
    CCDS22040.1
    UniProtKB/TrEMBL
    Q791X1, Q8BP34, Q91V06
    Conserved Domains (2) summary
    PTZ00341
    Location:184 → 268
    PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
    pfam02234
    Location:21 → 68
    CDI; Cyclin-dependent kinase inhibitor

  3. NM_001412230.1 → NP_001399159.1  cyclin-dependent kinase inhibitor 1C isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC023248

  4. NM_001412231.1 → NP_001399160.1  cyclin-dependent kinase inhibitor 1C isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC023248

  5. NM_001412232.1 → NP_001399161.1  cyclin-dependent kinase inhibitor 1C isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC023248
    UniProtKB/Swiss-Prot
    G3UW61, P49919

  6. NM_001412233.1 → NP_001399162.1  cyclin-dependent kinase inhibitor 1C isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC023248

  7. NM_001412234.1 → NP_001399163.1  cyclin-dependent kinase inhibitor 1C isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC023248

  8. NM_001412235.1 → NP_001399164.1  cyclin-dependent kinase inhibitor 1C isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC023248

  9. NM_001412236.1 → NP_001399165.1  cyclin-dependent kinase inhibitor 1C isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC023248

  10. NM_001412237.1 → NP_001399166.1  cyclin-dependent kinase inhibitor 1C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC023248
    UniProtKB/TrEMBL
    Q791X1, Q91V06

  11. NM_001412238.1 → NP_001399167.1  cyclin-dependent kinase inhibitor 1C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC023248
    UniProtKB/TrEMBL
    Q791X1, Q91V06

  12. NM_001412239.1 → NP_001399168.1  cyclin-dependent kinase inhibitor 1C isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC023248

  13. NM_001412240.1 → NP_001399169.1  cyclin-dependent kinase inhibitor 1C isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC023248

  14. NM_001412241.1 → NP_001399170.1  cyclin-dependent kinase inhibitor 1C isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC023248

  15. NM_001412242.1 → NP_001399171.1  cyclin-dependent kinase inhibitor 1C isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC023248

  16. NM_001412243.1 → NP_001399172.1  cyclin-dependent kinase inhibitor 1C isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC023248

  17. NM_001412244.1 → NP_001399173.1  cyclin-dependent kinase inhibitor 1C isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC023248

  18. NM_001412245.1 → NP_001399174.1  cyclin-dependent kinase inhibitor 1C isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC023248

  19. NM_001412246.1 → NP_001399175.1  cyclin-dependent kinase inhibitor 1C isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC023248

  20. NM_009876.5 → NP_034006.3  cyclin-dependent kinase inhibitor 1C isoform 2

    See identical proteins and their annotated locations for NP_034006.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame splice site in the 5' coding region and uses a downstream start codon, compared to variant 1. The encoded protein (isoform 2) has a shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AC023248
    Consensus CDS
    CCDS22040.1
    UniProtKB/TrEMBL
    Q791X1, Q8BP34, Q91V06
    Related
    ENSMUSP00000037302.7, ENSMUST00000037287.8
    Conserved Domains (2) summary
    PTZ00341
    Location:184 → 268
    PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
    pfam02234
    Location:21 → 68
    CDI; Cyclin-dependent kinase inhibitor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    143012076..143014735 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49919.2 GenPept UniProtKB/Swiss-Prot:P49919

Gene LinkOut

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