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Cd80 CD80 antigen [ Mus musculus (house mouse) ]

Gene ID: 12519, updated on 23-Mar-2024

Summary

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Official Symbol
Cd80provided by MGI
Official Full Name
CD80 antigenprovided by MGI
Primary source
MGI:MGI:101775
See related
Ensembl:ENSMUSG00000075122 AllianceGenome:MGI:101775
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B71; Ly53; TSA1; Cd28l; Ly-53; MIC17
Summary
Predicted to enable coreceptor activity. Acts upstream of or within T cell costimulation; cellular response to lipopolysaccharide; and positive regulation of alpha-beta T cell proliferation. Located in external side of plasma membrane. Is expressed in heart ventricle and skin. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human CD80 (CD80 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Cd80 in Genome Data Viewer
Location:
16 B4; 16 26.86 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (38277793..38316682)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (38457430..38495958)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40819 Neighboring gene STARR-seq mESC enhancer starr_40820 Neighboring gene predicted gene, 36333 Neighboring gene STARR-seq mESC enhancer starr_40821 Neighboring gene STARR-positive B cell enhancer ABC_E9931 Neighboring gene ADP-ribosylarginine hydrolase Neighboring gene STARR-seq mESC enhancer starr_40823 Neighboring gene STARR-positive B cell enhancer ABC_E9164 Neighboring gene STARR-seq mESC enhancer starr_40825 Neighboring gene STARR-positive B cell enhancer ABC_E7448 Neighboring gene SET domain-containing protein 8 pseudogene Neighboring gene predicted gene, 41453 Neighboring gene creatine kinase pseudogene 3 Neighboring gene translocase of inner mitochondrial membrane domain containing 1 Neighboring gene ubiquitin-like, containing PHD and RING finger domains, 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40830 Neighboring gene predicted gene, 53953 Neighboring gene protein O-glucosyltransferase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CTLA-4-Ig internalizes CD80 in fibroblast-like synoviocytes from chronic inflammatory arthritis mouse model. Miura Y, et al. Sci Rep, 2022 Sep 30. PMID 36180526, Free PMC Article
  2. B7-1 mediates podocyte injury and glomerulosclerosis through communication with Hsp90ab1-LRP5-β-catenin pathway. Li J, et al. Cell Death Differ, 2022 Dec. PMID 35710882, Free PMC Article
  3. Expression of Murine CD80 by Herpes Simplex Virus 1 in Place of Latency-Associated Transcript (LAT) Can Compensate for Latency Reactivation and Anti-apoptotic Functions of LAT. Jaggi U, et al. J Virol, 2020 Feb 28. PMID 31852788, Free PMC Article
  4. CD80 Plays a Critical Role in Increased Inflammatory Responses in Herpes Simplex Virus 1-Infected Mouse Corneas. Tormanen K, et al. J Virol, 2020 Jan 6. PMID 31619558, Free PMC Article
  5. CD80 Expressed by CD8(+) T Cells Contributes to PD-L1-Induced Apoptosis of Activated CD8(+) T Cells. Rollins MR, et al. J Immunol Res, 2017. PMID 29181416, Free PMC Article

See all (374) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Absence of CD80 reduces HSV-1 replication in the eye and delays reactivation but not latency levels.
    Title: Absence of CD80 reduces HSV-1 replication in the eye and delays reactivation but not latency levels.
  2. cis-B7:CD28 interactions at invaginated synaptic membranes provide CD28 co-stimulation and promote CD8[+] T cell function and anti-tumor immunity.
    Title: cis-B7:CD28 interactions at invaginated synaptic membranes provide CD28 co-stimulation and promote CD8(+) T cell function and anti-tumor immunity.
  3. CTLA-4-Ig internalizes CD80 in fibroblast-like synoviocytes from chronic inflammatory arthritis mouse model.
    Title: CTLA-4-Ig internalizes CD80 in fibroblast-like synoviocytes from chronic inflammatory arthritis mouse model.
  4. Lack of Functional P110delta Affects Expression of Activation Marker CD80 but Does Not Influence Functions of Neutrophils.
    Title: Lack of Functional P110δ Affects Expression of Activation Marker CD80 but Does Not Influence Functions of Neutrophils.
  5. Suppression of CD80 Expression by ICP22 Affects Herpes Simplex Virus Type 1 Replication and CD8(+)IFN-gamma(+) Infiltrates in the Eyes of Infected Mice but Not Latency Reactivation.
    Title: Suppression of CD80 Expression by ICP22 Affects Herpes Simplex Virus Type 1 Replication and CD8(+)IFN-γ(+) Infiltrates in the Eyes of Infected Mice but Not Latency Reactivation.
  6. B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms.
    Title: B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms.
  7. Expression of Murine CD80 by Herpes Simplex Virus 1 in Place of Latency-Associated Transcript (LAT) Can Compensate for Latency Reactivation and Anti-apoptotic Functions of LAT.
    Title: Expression of Murine CD80 by Herpes Simplex Virus 1 in Place of Latency-Associated Transcript (LAT) Can Compensate for Latency Reactivation and Anti-apoptotic Functions of LAT.
  8. these results suggest that increased CD80 levels promote increased CD8(+) T cells, leading to exacerbated eye disease in HSV-1-infected mice.
    Title: CD80 Plays a Critical Role in Increased Inflammatory Responses in Herpes Simplex Virus 1-Infected Mouse Corneas.
  9. This study provide evidence for a major role of CD80 in orchestrating immune surveillance of colon preneoplastic lesions and might help to develop novel approaches that exploit anti-tumor immunity to prevent and control colon cancer.
    Title: Epithelial CD80 promotes immune surveillance of colonic preneoplastic lesions and its expression is increased by oxidative stress through STAT3 in colon cancer cells.
  10. CD28 may play a role in LPS nephropathy. Immunofluorescence colocalization analysis revealed a tight association of gammadeltaT cells with B7-1 in the kidney. High B7-1 expression was detected in podocytes treated with LPS.
    Title: γδT Cells Exacerbate Podocyte Injury via the CD28/B7-1-Phosphor-SRC Kinase Pathway.
Submit: New GeneRIF Correction See all GeneRIFs (143)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables coreceptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables receptor ligand activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in T cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in T cell costimulation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within T cell costimulation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of T cell mediated immunity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of T cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of alpha-beta T cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of protein complex involved in cell adhesion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
T-lymphocyte activation antigen CD80
Names
B7 protein
activation B7-1 antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359898.1 → NP_001346827.1  T-lymphocyte activation antigen CD80 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC209577
    Consensus CDS
    CCDS28168.1
    UniProtKB/Swiss-Prot
    Q00609, Q61332
    UniProtKB/TrEMBL
    Q3U4B5, Q549R2, Q9R1Z9
    Conserved Domains (2) summary
    cd16083
    Location:145 → 235
    IgC_CD80; Immunoglobulin constant (IgC)-like domain of antigen receptor CD80
    cd16086
    Location:39 → 142
    IgV_CD80; Immunoglobulin variable domain (IgV) in CD80

  2. NM_009855.2 → NP_033985.3  T-lymphocyte activation antigen CD80 precursor

    See identical proteins and their annotated locations for NP_033985.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC154425, X60958
    Consensus CDS
    CCDS28168.1
    UniProtKB/Swiss-Prot
    Q00609, Q61332
    UniProtKB/TrEMBL
    Q3U4B5, Q549R2, Q9R1Z9
    Related
    ENSMUSP00000097404.3, ENSMUST00000099816.3
    Conserved Domains (2) summary
    cd16083
    Location:145 → 235
    IgC_CD80; Immunoglobulin constant (IgC)-like domain of antigen receptor CD80
    cd16086
    Location:39 → 142
    IgV_CD80; Immunoglobulin variable domain (IgV) in CD80

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    38277793..38316682
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159758.1 → XP_036015651.1  T-lymphocyte activation antigen CD80 isoform X1

    UniProtKB/TrEMBL
    Q3U4B5
    Related
    ENSMUSP00000156031.2, ENSMUST00000231716.2
    Conserved Domains (2) summary
    cd16086
    Location:47 → 150
    IgV_CD80; Immunoglobulin variable domain (IgV) in Cluster of Differentiation (CD) 80
    cd16083
    Location:153 → 243
    IgC1_CD80; Immunoglobulin constant (IgC)-like domain of antigen receptor Cluster of Differentiation (CD) 80; member of the C1-set of Ig superfamily (IgSF) domains

  2. XM_030248945.2 → XP_030104805.1  T-lymphocyte activation antigen CD80 isoform X2

    Related
    ENSMUSP00000156252.2, ENSMUST00000232409.2
    Conserved Domains (1) summary
    cl11960
    Location:47 → 150
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q00609.1 GenPept UniProtKB/Swiss-Prot:Q00609

Gene LinkOut

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