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Cd68 CD68 antigen [ Mus musculus (house mouse) ]

Gene ID: 12514, updated on 5-Mar-2024

Summary

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Official Symbol
Cd68provided by MGI
Official Full Name
CD68 antigenprovided by MGI
Primary source
MGI:MGI:88342
See related
Ensembl:ENSMUSG00000018774 AllianceGenome:MGI:88342
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lamp4; gp110; Scard1
Summary
Involved in several processes, including cellular response to lipopolysaccharide; cellular response to oxidised low-density lipoprotein particle stimulus; and negative regulation of dendritic cell antigen processing and presentation. Acts upstream of or within aging and cellular response to organic substance. Located in lysosome and plasma membrane. Is expressed in several structures, including central nervous system; embryo mesenchyme; heart blood vessel; liver; and spleen. Orthologous to human CD68 (CD68 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 35.5), thymus adult (RPKM 25.5) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Cd68 in Genome Data Viewer
Location:
11 B3; 11 42.86 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69555039..69556996, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69664213..69666170, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene SRY (sex determining region Y)-box 15 Neighboring gene mannose-P-dolichol utilization defect 1 Neighboring gene STARR-positive B cell enhancer ABC_E3965 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:69476301-69476484 Neighboring gene microRNA 1934 Neighboring gene eukaryotic translation initiation factor 4A1 Neighboring gene predicted gene, 24029 Neighboring gene predicted gene, 25835

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Myeloid-restricted CD68 deficiency attenuates atherosclerosis via inhibition of ROS-MAPK-apoptosis axis. Duan L, et al. Biochim Biophys Acta Mol Basis Dis, 2023 Jun. PMID 36965676
  2. The class D scavenger receptor CD68 contributes to mouse chronic liver injury. Yang L, et al. Immunol Res, 2018 Jun. PMID 29804196
  3. Osteoclast precursors do not express CD68: results from CD68 promoter-driven RANK transgenic mice. Jackson MF, et al. FEBS Lett, 2017 Mar. PMID 28173622, Free PMC Article
  4. Genetic ablation of CD68 results in mice with increased bone and dysfunctional osteoclasts. Ashley JW, et al. PLoS One, 2011. PMID 21991369, Free PMC Article
  5. Tumor progression stage and anatomical site regulate tumor-associated macrophage and bone marrow-derived monocyte polarization. Redente EF, et al. Am J Pathol, 2010 Jun. PMID 20431028, Free PMC Article

See all (104) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Microglial CD68 and L-ferritin upregulation in response to phosphorylated-TDP-43 pathology in the amyotrophic lateral sclerosis brain.
    Title: Microglial CD68 and L-ferritin upregulation in response to phosphorylated-TDP-43 pathology in the amyotrophic lateral sclerosis brain.
  2. Myeloid-restricted CD68 deficiency attenuates atherosclerosis via inhibition of ROS-MAPK-apoptosis axis.
    Title: Myeloid-restricted CD68 deficiency attenuates atherosclerosis via inhibition of ROS-MAPK-apoptosis axis.
  3. Autophagic reprogramming of bone marrow-derived macrophages.
    Title: Autophagic reprogramming of bone marrow-derived macrophages.
  4. Scavenger receptor CD68 antigen plays a role in chronic liver injury, which has implications for the design of anti-fibrotic therapies.
    Title: The class D scavenger receptor CD68 contributes to mouse chronic liver injury.
  5. Findings indicate that human CD68 and its mouse ortholog macrosialin located in the lysosomal membrane and share many structural similarities.
    Title: CD68/macrosialin: not just a histochemical marker.
  6. Myeloid osteoclast precursors do not express CD68.
    Title: Osteoclast precursors do not express CD68: results from CD68 promoter-driven RANK transgenic mice.
  7. CD68, a putative receptor for sporozoite invasion of Kupffer cells that acts as a gateway for malaria infection of the liver.
    Title: CD68 acts as a major gateway for malaria sporozoite liver infection.
  8. Results showed that activated microglia in Alzheimer's disease-like mice showed two-step transition: a CD68-negative activated form at 6-9 months and a CD68-positive form from 12 months of age
    Title: Temporal changes of CD68 and α7 nicotinic acetylcholine receptor expression in microglia in Alzheimer's disease-like mouse models.
  9. Statins promote the beneficial remodeling of plaques in diseased mouse arteries through the stimulation of the CCR7 / CD68 emigration pathway in macrophages
    Title: Statins promote the regression of atherosclerosis via activation of the CCR7-dependent emigration pathway in macrophages.
  10. These findings demonstrate a role for CD68 in the function of osteoclasts.
    Title: Genetic ablation of CD68 results in mice with increased bone and dysfunctional osteoclasts.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (4)  1 citation
  • Endonuclease-mediated (8) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in autocrine signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to nutrient levels IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cellular response to organic substance IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to oxidised low-density lipoprotein particle stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in establishment of protein localization to organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inflammatory response to antigenic stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of dendritic cell antigen processing and presentation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosomal membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
macrosialin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291058.1 → NP_001277987.1  macrosialin precursor

    See identical proteins and their annotated locations for NP_001277987.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
    Source sequence(s)
    AW123877, BY210951, X68273
    Consensus CDS
    CCDS70216.1
    UniProtKB/Swiss-Prot
    O54688, O70321, P31996, Q3S4A9, Q5F2A8, Q9DD15
    UniProtKB/TrEMBL
    A0A0R4J1C8
    Related
    ENSMUSP00000018918.6, ENSMUST00000018918.12
    Conserved Domains (2) summary
    pfam01299
    Location:36 → 326
    Lamp; Lysosome-associated membrane glycoprotein (Lamp)
    pfam05647
    Location:43 → 102
    Epiglycanin_TR; Tandem-repeating region of mucin, epiglycanin-like

RNA

  1. NR_110993.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AW123877, BY207885, BY210951, X68273

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    69555039..69556996 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_009853.1: Suppressed sequence

    Description
    NM_009853.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P31996.1 GenPept UniProtKB/Swiss-Prot:P31996

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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