Cd44 CD44 antigen [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd44provided by MGI
Official Full Name: CD44 antigenprovided by MGI
Primary source: MGI:MGI:88338
See related: Ensembl:ENSMUSG00000005087 AllianceGenome:MGI:88338
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ly-24; Pgp-1; HERMES
Summary: Enables hyaluronic acid binding activity and type II transforming growth factor beta receptor binding activity. Contributes to cytokine binding activity and cytokine receptor activity. Involved in several processes, including negative regulation of T cell activation; positive regulation of protein phosphorylation; and regulation of intracellular signal transduction. Acts upstream of or within several processes, including Wnt signaling pathway; morphogenesis of a branching epithelium; and wound healing involved in inflammatory response. Located in basolateral plasma membrane; external side of plasma membrane; and microvillus. Part of macrophage migration inhibitory factor receptor complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and limb. Human ortholog(s) of this gene implicated in breast carcinoma (multiple); carcinoma (multiple); and prostate cancer. Orthologous to human CD44 (CD44 molecule (Indian blood group)). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in lung adult (RPKM 13.1), spleen adult (RPKM 8.5) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E2; 2 54.13 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (102641486..102732014, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (102811141..102901669, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Impact of heterogeneous nuclear ribonucleoprotein A/B subtype overexpression on the expression of cancer stem cell markers CD133 and CD44 and cellular proliferation capacity.
Title: Impact of heterogeneous nuclear ribonucleoprotein A/B subtype overexpression on the expression of cancer stem cell markers CD133 and CD44 and cellular proliferation capacity.
Cell aggregation activates small GTPase Rac1 and induces CD44 cleavage by maintaining lipid raft integrity.
Title: Cell aggregation activates small GTPase Rac1 and induces CD44 cleavage by maintaining lipid raft integrity.
Hyaluronan-CD44 Interaction Regulates Mouse Retinal Progenitor Cells Migration, Proliferation and Neuronal Differentiation.
Title: Hyaluronan-CD44 Interaction Regulates Mouse Retinal Progenitor Cells Migration, Proliferation and Neuronal Differentiation.
Overexpressed CD44 is associated with B-cell activation via the HA-CD44-AIM2 pathway in lupus B cells.
Title: Overexpressed CD44 is associated with B-cell activation via the HA-CD44-AIM2 pathway in lupus B cells.
CD44 connects autophagy decline and ageing in the vascular endothelium.
Title: CD44 connects autophagy decline and ageing in the vascular endothelium.
CD44 regulates Epac1-mediated beta-adrenergic-receptor-induced Ca[2+]-handling abnormalities: implication in cardiac arrhythmias.
Title: CD44 regulates Epac1-mediated β-adrenergic-receptor-induced Ca(2+)-handling abnormalities: implication in cardiac arrhythmias.
Astrocytic CD44 Deficiency Reduces the Severity of Kainate-Induced Epilepsy.
Title: Astrocytic CD44 Deficiency Reduces the Severity of Kainate-Induced Epilepsy.
Milk osteopontin promotes intestinal development by up-regulating the expression of integrin alphavbeta3 and CD44.
Title: Milk osteopontin promotes intestinal development by up-regulating the expression of integrin αvβ3 and CD44.
Deletion of Cd44 Inhibits Metastasis Formation of Liver Cancer in Nf2-Mutant Mice.
Title: Deletion of Cd44 Inhibits Metastasis Formation of Liver Cancer in Nf2-Mutant Mice.
Preparation of chitosan nanoparticle containing recombinant CD44v antigen and evaluation of its immunization capacity against breast cancer in BALB/c mice.
Title: Preparation of chitosan nanoparticle containing recombinant CD44v antigen and evaluation of its immunization capacity against breast cancer in BALB/c mice.

Submit: New GeneRIF Correction See all GeneRIFs (292)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (12) 1 citation
Chemically induced (ENU) (1)
Endonuclease-mediated (9)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cd44 (e-PCR), detects polymorphism
- UniSTS:526852

Cd44 (e-PCR), detects polymorphism
- UniSTS:525573

Cd44 (e-PCR), detects polymorphism
- UniSTS:525574

Cd44 (e-PCR), detects polymorphism
- UniSTS:525575

Cd44 (e-PCR), detects polymorphism
- UniSTS:525576

Cd44 (e-PCR), detects polymorphism
- UniSTS:525577

Cd44 (e-PCR), detects polymorphism
- UniSTS:525578

PMC111028P1 (e-PCR)
- UniSTS:270201

Cd44 (e-PCR), detects polymorphism
- UniSTS:275889

Cd44 (e-PCR), detects polymorphism
- UniSTS:141285

AW146109 (e-PCR)
- UniSTS:178664

AW121933 (e-PCR)
- UniSTS:178665

J05163 (e-PCR)
- UniSTS:178666

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cargo receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables cargo receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cargo receptor activity	ISO Inferred from Sequence Orthology more info	PubMed
enables channel regulator activity	ISO Inferred from Sequence Orthology more info	PubMed
contributes_to cytokine binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to cytokine receptor activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to cytokine receptor activity	ISO Inferred from Sequence Orthology more info
enables epidermal growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables hyaluronic acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables hyaluronic acid binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables hyaluronic acid binding	ISO Inferred from Sequence Orthology more info
enables phosphoprotein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables type II transforming growth factor beta receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within branching involved in prostate gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cellular response to fibroblast growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in hyaluronan catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in hyaluronan catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hyaluronan catabolic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in macrophage fusion	ISO Inferred from Sequence Orthology more info
involved_in monocyte aggregation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of CD4-positive, alpha-beta T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mature B cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of regulatory T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of adaptive immune response	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monocyte aggregation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neutrophil apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in receptor-mediated endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor-mediated endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of lamellipodium morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within wound healing involved in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing, spreading of cells	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell projection	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in lamellipodium membrane	ISO Inferred from Sequence Orthology more info
part_of macrophage migration inhibitory factor receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of macrophage migration inhibitory factor receptor complex	IDA Inferred from Direct Assay more info	PubMed
part_of macrophage migration inhibitory factor receptor complex	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane raft	ISO Inferred from Sequence Orthology more info	PubMed
located_in microvillus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CD44 antigen

Names: ECMR-III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; PGP-I; extracellular matrix receptor III; hermes antigen; hyaluronate receptor; lymphocyte antigen 24; phagocytic glycoprotein 1; phagocytic glycoprotein I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039150.1 → NP_001034239.1 CD44 antigen isoform b precursor

See identical proteins and their annotated locations for NP_001034239.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks several alternate, in-frame, exons, compared to variant 1. The resulting protein (isoform b) is shorter when it is compared to isoform a.

Source sequence(s)

AL844155, CT010324

Consensus CDS

CCDS16470.1

UniProtKB/TrEMBL

E9QKM8, Q80X37

Related

ENSMUSP00000062330.8, ENSMUST00000060516.14

Conserved Domains (1) summary

cd03516
Location:30 → 173

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
NM_001039151.1 → NP_001034240.1 CD44 antigen isoform c precursor

See identical proteins and their annotated locations for NP_001034240.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks several alternate, in-frame, exons, compared to variant 1. The resulting protein (isoform c) is shorter when it is compared to isoform a.

Source sequence(s)

AK045226, AL844155

Consensus CDS

CCDS16471.1

UniProtKB/TrEMBL

Q3U468, Q3U8S1, Q3UNN2

Related

ENSMUSP00000097265.3, ENSMUST00000099673.9

Conserved Domains (1) summary

cd03516
Location:30 → 173

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
NM_001177785.1 → NP_001171256.1 CD44 antigen isoform d precursor

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks several alternate, in-frame, exons, compared to variant 1. The resulting protein (isoform d) is shorter when it is compared to isoform a.

Source sequence(s)

AJ251594, AK045226, AL844155

Consensus CDS

CCDS50650.1

UniProtKB/TrEMBL

A2APM1, E9QKM8

Related

ENSMUSP00000106829.3, ENSMUST00000111198.9

Conserved Domains (1) summary

cd03516
Location:30 → 173

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
NM_001177786.1 → NP_001171257.1 CD44 antigen isoform e precursor

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks several alternate, in-frame, exons, compared to variant 1. The resulting protein (isoform e) is shorter when it is compared to isoform a.

Source sequence(s)

AJ251594, AK045226, AL844155

Consensus CDS

CCDS50649.1

UniProtKB/TrEMBL

A2APM4, A2APM5

Related

ENSMUSP00000106822.3, ENSMUST00000111191.9

Conserved Domains (1) summary

cd03516
Location:30 → 173

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
NM_001177787.1 → NP_001171258.1 CD44 antigen isoform f precursor

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks several alternate, in-frame, exons, compared to variant 1. The resulting protein (isoform f) is shorter when it is compared to isoform a.

Source sequence(s)

AJ251594, AK045226, AL844155

Consensus CDS

CCDS50648.1

UniProtKB/TrEMBL

A2APM3, A2APM5

Related

ENSMUSP00000106821.3, ENSMUST00000111190.9

Conserved Domains (1) summary

cd03516
Location:30 → 173

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
NM_009851.2 → NP_033981.2 CD44 antigen isoform a precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform a).

Source sequence(s)

AJ251594, AK045226, AL844155

Consensus CDS

CCDS16472.1

UniProtKB/Swiss-Prot

P15379, Q05732, Q61395, Q62060, Q62061, Q62062, Q62063, Q62408, Q62409, Q64296, Q99J14, Q9QYX8

UniProtKB/TrEMBL

A2APM2

Related

ENSMUSP00000005218.9, ENSMUST00000005218.15

Conserved Domains (1) summary

cd03516
Location:30 → 173

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

102641486..102732014 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006498649.2 → XP_006498712.1 CD44 antigen isoform X4

UniProtKB/TrEMBL

E9QKM8

Conserved Domains (1) summary

cd03516
Location:30 → 173

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_006498647.2 → XP_006498710.1 CD44 antigen isoform X2

UniProtKB/Swiss-Prot

P15379, Q05732, Q61395, Q62060, Q62061, Q62062, Q62063, Q62408, Q62409, Q64296, Q99J14, Q9QYX8

Conserved Domains (1) summary

cd03516
Location:30 → 173

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_006498646.2 → XP_006498709.1 CD44 antigen isoform X1

UniProtKB/Swiss-Prot

P15379, Q05732, Q61395, Q62060, Q62061, Q62062, Q62063, Q62408, Q62409, Q64296, Q99J14, Q9QYX8

Conserved Domains (1) summary

cd03516
Location:30 → 173

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_006498648.2 → XP_006498711.1 CD44 antigen isoform X3

Conserved Domains (1) summary

cd03516
Location:30 → 173

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...