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Entpd5 ectonucleoside triphosphate diphosphohydrolase 5 [ Mus musculus (house mouse) ]

Gene ID: 12499, updated on 5-Mar-2024

Summary

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Official Symbol
Entpd5provided by MGI
Official Full Name
ectonucleoside triphosphate diphosphohydrolase 5provided by MGI
Primary source
MGI:MGI:1321385
See related
Ensembl:ENSMUSG00000021236 AllianceGenome:MGI:1321385
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pcph; Cd39l4; mNTPase; NTPDase5; ER-UDPase; NTPDase-5
Summary
Enables guanosine-diphosphatase activity and uridine-diphosphatase activity. Involved in several processes, including positive regulation of glycolytic process; protein N-linked glycosylation; and regulation of phosphatidylinositol 3-kinase signaling. Located in endoplasmic reticulum. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system gland; liver; and nose. Orthologous to human ENTPD5 (ectonucleoside triphosphate diphosphohydrolase 5 (inactive)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney adult (RPKM 30.8), bladder adult (RPKM 19.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 D1; 12 39.18 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (84420649..84455803, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (84373875..84409029, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 410 Neighboring gene LSM6 homolog, U6 small nuclear RNA associated pseudogene Neighboring gene family with sequence similarity 161, member B Neighboring gene STARR-positive B cell enhancer ABC_E1445 Neighboring gene coenzyme Q6 monooxygenase Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:85729760-85729947 Neighboring gene STARR-positive B cell enhancer ABC_E8493 Neighboring gene basal body orientation factor 1 Neighboring gene ring finger protein 113A2 Neighboring gene aldehyde dehydrogenase family 6, subfamily A1 Neighboring gene STARR-positive B cell enhancer ABC_E80

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ectonucleoside triphosphate diphosphohydrolase type 5 (Entpd5)-deficient mice develop progressive hepatopathy, hepatocellular tumors, and spermatogenic arrest. Read R, et al. Vet Pathol, 2009 May. PMID 19176496
  2. The UDPase ENTPD5 regulates ER stress-associated renal injury by mediating protein N-glycosylation. Xu L, et al. Cell Death Dis, 2023 Feb 27. PMID 36849424, Free PMC Article
  3. Sequencing, functional expression and characterization of rat NTPDase6, a nucleoside diphosphatase and novel member of the ecto-nucleoside triphosphate diphosphohydrolase family. Braun N, et al. Biochem J, 2000 Nov 1. PMID 11042118, Free PMC Article
  4. Glycoprotein reglucosylation and nucleotide sugar utilization in the secretory pathway: identification of a nucleoside diphosphatase in the endoplasmic reticulum. Trombetta ES, et al. EMBO J, 1999 Jun 15. PMID 10369669, Free PMC Article
  5. The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway. Fang M, et al. Cell, 2010 Nov 24. PMID 21074248

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The UDPase ENTPD5 regulates ER stress-associated renal injury by mediating protein N-glycosylation.
    Title: The UDPase ENTPD5 regulates ER stress-associated renal injury by mediating protein N-glycosylation.
  2. Six proteins were regulated at both basal and inducible levels exhibiting the largest dynamic range of Nrf2 regulation: cytochrome CYP2A5, GSTM3, GSTM1, ENTPD5,UDPGDH, and EPHX1.
    Title: Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: biochemical, pharmacological and toxicological implications.
  3. During a study using the embryonic fibroblasts from the PTEN null mice ENTPD5, is found to be upregulated by AKT activation; this enzyme seems to mediate many of the observed cancer-related phenotypes associated with AKT activation.
    Title: The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway.
  4. The effect of Entpd5 deletion on the development of hepatocellualr neoplasia in mice is reported.
    Title: Ectonucleoside triphosphate diphosphohydrolase type 5 (Entpd5)-deficient mice develop progressive hepatopathy, hepatocellular tumors, and spermatogenic arrest.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ADP phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables CDP phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables GDP phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GDP phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GDP phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables IDP phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables UDP phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UDP phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleoside diphosphate phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables ribonucleoside triphosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_positive_effect 'de novo' post-translational protein folding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in UDP catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_positive_effect UDP-glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleoside diphosphate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_positive_effect protein N-linked glycosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
NOT located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum lumen ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ectonucleoside triphosphate diphosphohydrolase 5
Names
CD39 antigen-like 4
GDPase ENTPD5
NTPDase 5
UDPase ENTPD5
guanosine-diphosphatase ENTPD5
nucleoside diphosphatase
uridine-diphosphatase ENTPD5
NP_001021385.1
NP_001272978.1
NP_001272987.1
NP_031673.2
XP_030102393.1
XP_036013066.1
XP_036013067.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001026214.2 → NP_001021385.1  ectonucleoside triphosphate diphosphohydrolase 5 isoform b precursor

    See identical proteins and their annotated locations for NP_001021385.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes the predominant protein (isoform b). Variants 2, 3 and 4 encode the same isoform b.
    Source sequence(s)
    AK081435, AK160950, BY049870, CD775710
    Consensus CDS
    CCDS26045.1
    UniProtKB/Swiss-Prot
    O70214, Q544J4, Q8BR23, Q8CD29, Q9WUZ9
    Related
    ENSMUSP00000105901.3, ENSMUST00000110272.9
    Conserved Domains (1) summary
    cl17037
    Location:38 → 423
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  2. NM_001286049.1 → NP_001272978.1  ectonucleoside triphosphate diphosphohydrolase 5 isoform b precursor

    See identical proteins and their annotated locations for NP_001272978.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 2. It encodes the predominant protein (isoform b). Variants 2, 3 and 4 encode the same isoform b.
    Source sequence(s)
    AC120402, AK002618, AK160950, CD775710
    Consensus CDS
    CCDS26045.1
    UniProtKB/Swiss-Prot
    O70214, Q544J4, Q8BR23, Q8CD29, Q9WUZ9
    Related
    ENSMUSP00000113106.2, ENSMUST00000122194.8
    Conserved Domains (1) summary
    cl17037
    Location:38 → 423
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  3. NM_001286058.1 → NP_001272987.1  ectonucleoside triphosphate diphosphohydrolase 5 isoform b precursor

    See identical proteins and their annotated locations for NP_001272987.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 2. It encodes the predominant protein (isoform b). Variants 2, 3 and 4 encode the same isoform b.
    Source sequence(s)
    AC120402, AK079267, AK160950, CD775710
    Consensus CDS
    CCDS26045.1
    UniProtKB/Swiss-Prot
    O70214, Q544J4, Q8BR23, Q8CD29, Q9WUZ9
    Related
    ENSMUSP00000114011.2, ENSMUST00000117286.2
    Conserved Domains (1) summary
    cl17037
    Location:38 → 423
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  4. NM_007647.3 → NP_031673.2  ectonucleoside triphosphate diphosphohydrolase 5 isoform a

    See identical proteins and their annotated locations for NP_031673.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an internal exon in the 5' region, which results in an upstream AUG start codon, compared to variant 2. The resulting isoform (a) has a longer N-terminus, compared to isoform b.
    Source sequence(s)
    AK160950, AK163688, BY049870, CD775710
    Consensus CDS
    CCDS36491.1
    UniProtKB/TrEMBL
    Q3TQC7
    Related
    ENSMUSP00000071939.6, ENSMUST00000072061.12
    Conserved Domains (1) summary
    cl17037
    Location:63 → 448
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    84420649..84455803 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157174.1 → XP_036013067.1  ectonucleoside triphosphate diphosphohydrolase 5 isoform X2

    UniProtKB/Swiss-Prot
    O70214, Q544J4, Q8BR23, Q8CD29, Q9WUZ9
    Conserved Domains (1) summary
    cl17037
    Location:38 → 423
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  2. XM_036157173.1 → XP_036013066.1  ectonucleoside triphosphate diphosphohydrolase 5 isoform X1

    UniProtKB/TrEMBL
    Q3TQC7
    Conserved Domains (1) summary
    cl17037
    Location:63 → 448
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  3. XM_030246533.1 → XP_030102393.1  ectonucleoside triphosphate diphosphohydrolase 5 isoform X2

    UniProtKB/Swiss-Prot
    O70214, Q544J4, Q8BR23, Q8CD29, Q9WUZ9
    Conserved Domains (1) summary
    cl17037
    Location:38 → 423
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WUZ9.1 GenPept UniProtKB/Swiss-Prot:Q9WUZ9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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