Cd28 CD28 antigen [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd28provided by MGI
Official Full Name: CD28 antigenprovided by MGI
Primary source: MGI:MGI:88327
See related: Ensembl:ENSMUSG00000026012 AllianceGenome:MGI:88327
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables protein kinase binding activity. Acts upstream of or within several processes, including positive regulation of immune response; positive regulation of intracellular signal transduction; and regulation of lymphocyte activation. Located in external side of plasma membrane and immunological synapse. Human ortholog(s) of this gene implicated in multiple sclerosis and type 1 diabetes mellitus. Orthologous to human CD28 (CD28 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in thymus adult (RPKM 17.9), spleen adult (RPKM 1.8) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 1 C2; 1 30.52 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (60785547..60812521)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (60746388..60773359)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

cis-B7:CD28 interactions at invaginated synaptic membranes provide CD28 co-stimulation and promote CD8[+] T cell function and anti-tumor immunity.
Title: cis-B7:CD28 interactions at invaginated synaptic membranes provide CD28 co-stimulation and promote CD8(+) T cell function and anti-tumor immunity.
Helios[+] and RORgammat[+] Treg populations are differentially regulated by MHCII, CD28, and ICOS to shape the intestinal Treg pool.
Title: Helios(+) and RORγt(+) Treg populations are differentially regulated by MHCII, CD28, and ICOS to shape the intestinal Treg pool.
CD28-signaling can be partially compensated in CD28-knockout mice but is essential for virus elimination in a murine model of multiple sclerosis.
Title: CD28-signaling can be partially compensated in CD28-knockout mice but is essential for virus elimination in a murine model of multiple sclerosis.
Costimulatory and coinhibitory molecules of B7-CD28 family in cardiovascular atherosclerosis: A review.
Title: Costimulatory and coinhibitory molecules of B7-CD28 family in cardiovascular atherosclerosis: A review.
Absence of CD28-CTLA4-PD-L1 Costimulatory Molecules Reduces Herpes Simplex Virus 1 Reactivation.
Title: Absence of CD28-CTLA4-PD-L1 Costimulatory Molecules Reduces Herpes Simplex Virus 1 Reactivation.
CD28 is expressed by macrophages with anti-inflammatory potential and limits their T-cell activating capacity.
Title: CD28 is expressed by macrophages with anti-inflammatory potential and limits their T-cell activating capacity.
Superior inhibition of alloantibody responses with selective CD28 blockade is CTLA-4 dependent and T follicular helper cell specific.
Title: Superior inhibition of alloantibody responses with selective CD28 blockade is CTLA-4 dependent and T follicular helper cell specific.
CD28 Regulates Metabolic Fitness for Long-Lived Plasma Cell Survival.
Title: CD28 Regulates Metabolic Fitness for Long-Lived Plasma Cell Survival.
The CD28 Transmembrane Domain Contains an Essential Dimerization Motif.
Title: The CD28 Transmembrane Domain Contains an Essential Dimerization Motif.
CD28 Agonism Improves Survival in Immunologically Experienced Septic Mice via IL-10 Released by Foxp3(+) Regulatory T Cells.
Title: CD28 Agonism Improves Survival in Immunologically Experienced Septic Mice via IL-10 Released by Foxp3(+) Regulatory T Cells.

Submit: New GeneRIF Correction See all GeneRIFs (180)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (10) 1 citation
Endonuclease-mediated (6)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of CD4-positive, alpha-beta T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of CD4-positive, alpha-beta T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T cell activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in T cell activation	ISO Inferred from Sequence Orthology more info
involved_in T cell costimulation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within T cell costimulation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within T cell costimulation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within T cell costimulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T cell costimulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within T cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of interleukin-2 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative thymic T cell selection	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of CD4-positive, alpha-beta T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of CD4-positive, alpha-beta T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of T cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of inflammatory response to antigenic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interleukin-2 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-4 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of isotype switching to IgG isotypes	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitotic nuclear division	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of T cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of regulatory T cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulatory T cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in immunological synapse	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein complex involved in cell adhesion	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: T-cell-specific surface glycoprotein CD28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007642.4 → NP_031668.3 T-cell-specific surface glycoprotein CD28 precursor

See identical proteins and their annotated locations for NP_031668.3

Status: VALIDATED

Source sequence(s)

AK030812, AK037772, BC064058, BY225764

Consensus CDS

CCDS14992.1

UniProtKB/Swiss-Prot

P31041, Q6GSH7

UniProtKB/TrEMBL

Q8CDB3

Related

ENSMUSP00000027165.3, ENSMUST00000027165.3

Conserved Domains (1) summary

cl11960
Location:22 → 137

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

60785547..60812521

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036156388.1 → XP_036012281.1 T-cell-specific surface glycoprotein CD28 isoform X1

UniProtKB/TrEMBL

Q8CDB3

Conserved Domains (2) summary

cd00096
Location:16 → 20

Ig; Ig strand A [structural motif]

cl11960
Location:16 → 132

Ig; Immunoglobulin domain