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Ccne2 cyclin E2 [ Mus musculus (house mouse) ]

Gene ID: 12448, updated on 11-Apr-2024

Summary

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Official Symbol
Ccne2provided by MGI
Official Full Name
cyclin E2provided by MGI
Primary source
MGI:MGI:1329034
See related
Ensembl:ENSMUSG00000028212 AllianceGenome:MGI:1329034
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables cyclin-dependent protein serine/threonine kinase regulator activity. Acts upstream of or within several processes, including DNA metabolic process; homologous chromosome pairing at meiosis; and regulation of protein localization. Part of cyclin E2-CDK2 complex. Is expressed in several structures, including cerebral cortex and genitourinary system. Human ortholog(s) of this gene implicated in castration-resistant prostate carcinoma. Orthologous to human CCNE2 (cyclin E2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14 (RPKM 11.2), liver E14.5 (RPKM 8.4) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Ccne2 in Genome Data Viewer
Location:
4 A1; 4 5.07 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (11190489..11204781)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (11190433..11204779)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:11070406-11070589 Neighboring gene STARR-seq mESC enhancer starr_09590 Neighboring gene microRNA 684-2 Neighboring gene STARR-seq mESC enhancer starr_09592 Neighboring gene STARR-positive B cell enhancer mm9_chr4:11093717-11094018 Neighboring gene transformation related protein 53 inducible nuclear protein 1 Neighboring gene RIKEN cDNA A630034I12 gene Neighboring gene STARR-seq mESC enhancer starr_09593 Neighboring gene STARR-seq mESC enhancer starr_09594 Neighboring gene STARR-positive B cell enhancer ABC_E9234 Neighboring gene integrator complex subunit 8 Neighboring gene STARR-seq mESC enhancer starr_09596 Neighboring gene dpy-19 like 4 Neighboring gene epithelial splicing regulatory protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. E-type cyclins modulate telomere integrity in mammalian male meiosis. Manterola M, et al. Chromosoma, 2016 Jun. PMID 26712234, Free PMC Article
  2. Cyclin E is recruited to the nuclear matrix during differentiation, but is not recruited in cancer cells. Munkley J, et al. Nucleic Acids Res, 2011 Apr. PMID 21109536, Free PMC Article
  3. Aberrant cell cycle progression and endoreplication in regenerating livers of mice that lack a single E-type cyclin. Nevzorova YA, et al. Gastroenterology, 2009 Aug. PMID 19445941, Free PMC Article
  4. Regulation of cyclin E protein levels through E2F-mediated inhibition of degradation. Pajalunga D, et al. Cell Cycle, 2004 Dec. PMID 15611651
  5. Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells. Parisi T, et al. EMBO J, 2003 Sep 15. PMID 12970191, Free PMC Article

See all (89) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High CCNE2 expression is associated with hepatitis and hepatocarcinogenesis.
    Title: Loss of Cyclin E1 attenuates hepatitis and hepatocarcinogenesis in a mouse model of chronic liver injury.
  2. This approach allowed us to determine the identity of cyclin E protein partners, as well as phosphorylation substrates of cyclins E (cyclin E1and cyclin E2)and its associated kinase, Cdk2, in different mouse organs.
    Title: Proteomic Landscape of Tissue-Specific Cyclin E Functions in Vivo.
  3. Spermatocytes lacking cyclin E2 and one E1 allele (E1+/-E2-/-) displayed a high rate of telomere abnormalities but can progress to pachytene and diplotene stages.
    Title: E-type cyclins modulate telomere integrity in mammalian male meiosis.
  4. These results highlight a new role for E-type cyclins (Ccne1 and Ccne2) as important regulators of male meiosis.
    Title: Mammalian E-type cyclins control chromosome pairing, telomere stability and CDK2 localization in male meiosis.
  5. CaM-dependent cyclin E/CDK2 activity is mediator of known Ca2+ sensitivity of G1/S transition of vascular smooth muscle cells.
    Title: A calmodulin-binding site on cyclin E mediates Ca2+-sensitive G1/s transitions in vascular smooth muscle cells.
  6. During embryonic development, the needs for this cyclin can be overcome in mitotic cycles but not in endoreplicating cells.
    Title: Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells.
  7. These findings define a molecular function for E type cyclins (cyclins E1 and E2) in cell cycle reentry and reveal a differential requirement for cyclin E in normal versus oncogenic proliferation.
    Title: Cyclin E ablation in the mouse.
  8. We propose that such increased E2F activity stabilizes cyclin E and contributes to establish the high and persistent levels of the protein commonly found in human neoplasias.
    Title: Regulation of cyclin E protein levels through E2F-mediated inhibition of degradation.
  9. This work indicates that-in addition to their function as CDK activators-E cyclins play kinase-independent functions in cell-cycle progression.
    Title: Kinase-independent function of cyclin E.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin-dependent protein serine/threonine kinase regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA replication initiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chromosome organization involved in meiotic cell cycle IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within homologous chromosome pairing at meiosis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of protein localization IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within telomere maintenance IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cyclin E1-CDK2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cyclin E2-CDK2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cyclin E2-CDK2 complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
G1/S-specific cyclin-E2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037134.3 → NP_001032211.1  G1/S-specific cyclin-E2 isoform 1

    See identical proteins and their annotated locations for NP_001032211.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 3 and 5 encode the same isoform (1).
    Source sequence(s)
    AL840625
    Consensus CDS
    CCDS17965.1
    UniProtKB/Swiss-Prot
    Q9QWU5, Q9Z238
    UniProtKB/TrEMBL
    Q544H6, Q7TMS8
    Related
    ENSMUSP00000130693.2, ENSMUST00000170901.8
    Conserved Domains (2) summary
    pfam00134
    Location:112 → 239
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:241 → 361
    Cyclin_C; Cyclin, C-terminal domain

  2. NM_001282943.2 → NP_001269872.1  G1/S-specific cyclin-E2 isoform 1

    See identical proteins and their annotated locations for NP_001269872.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 3 and 5 encode the same isoform (1).
    Source sequence(s)
    AL840625
    Consensus CDS
    CCDS17965.1
    UniProtKB/Swiss-Prot
    Q9QWU5, Q9Z238
    UniProtKB/TrEMBL
    Q544H6, Q7TMS8
    Related
    ENSMUSP00000103960.4, ENSMUST00000108324.4
    Conserved Domains (2) summary
    pfam00134
    Location:112 → 239
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:241 → 361
    Cyclin_C; Cyclin, C-terminal domain

  3. NM_001419967.1 → NP_001406896.1  G1/S-specific cyclin-E2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AL840625
    UniProtKB/TrEMBL
    A2API1

  4. NM_001419968.1 → NP_001406897.1  G1/S-specific cyclin-E2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to varian 1. Variants 1, 3 and 5 encode the same isoform (1).
    Source sequence(s)
    AL840625
    UniProtKB/Swiss-Prot
    Q9QWU5, Q9Z238
    UniProtKB/TrEMBL
    Q544H6

  5. NM_001419969.1 → NP_001406898.1  G1/S-specific cyclin-E2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate in-frame splice site in the 5' coding region and differs in the 5' UTR compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AL840625
    UniProtKB/TrEMBL
    A2API1

  6. NM_009830.4 → NP_033960.1  G1/S-specific cyclin-E2 isoform 2

    See identical proteins and their annotated locations for NP_033960.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AL840625
    Consensus CDS
    CCDS17966.1
    UniProtKB/TrEMBL
    A2API1, Q7TMS8
    Related
    ENSMUSP00000029866.10, ENSMUST00000029866.16
    Conserved Domains (2) summary
    pfam00134
    Location:111 → 238
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:240 → 360
    Cyclin_C; Cyclin, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    11190489..11204781
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537574.5 → XP_006537637.1  G1/S-specific cyclin-E2 isoform X1

    See identical proteins and their annotated locations for XP_006537637.1

    UniProtKB/Swiss-Prot
    Q9QWU5, Q9Z238
    UniProtKB/TrEMBL
    Q544H6, Q7TMS8
    Conserved Domains (2) summary
    pfam00134
    Location:112 → 239
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:241 → 361
    Cyclin_C; Cyclin, C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z238.1 GenPept UniProtKB/Swiss-Prot:Q9Z238

Gene LinkOut

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