Ccnd1 cyclin D1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccnd1provided by MGI
Official Full Name: cyclin D1provided by MGI
Primary source: MGI:MGI:88313
See related: Ensembl:ENSMUSG00000070348 AllianceGenome:MGI:88313
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: cD1; CycD1; Cyl-1; PRAD1; bcl-1
Summary: Enables cyclin-dependent protein serine/threonine kinase regulator activity; protein kinase activity; and protein kinase binding activity. Involved in negative regulation of epithelial cell differentiation and negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including endoplasmic reticulum unfolded protein response; gland development; and positive regulation of mammary gland epithelial cell proliferation. Located in bicellular tight junction; cytoplasm; and nucleus. Part of cyclin-dependent protein kinase holoenzyme complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); colorectal cancer; hematologic cancer (multiple); invasive lobular carcinoma; and von Hippel-Lindau disease. Orthologous to human CCND1 (cyclin D1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 58.4), adrenal adult (RPKM 54.1) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F5; 7 88.92 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (144483668..144493568, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (144929931..144939831, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

alpha-synuclein regulates Cyclin D1 to promote abnormal initiation of the cell cycle and induce apoptosis in dopamine neurons.
Title: α-synuclein regulates Cyclin D1 to promote abnormal initiation of the cell cycle and induce apoptosis in dopamine neurons.
Cyclin D1 extensively reprograms metabolism to support biosynthetic pathways in hepatocytes.
Title: Cyclin D1 extensively reprograms metabolism to support biosynthetic pathways in hepatocytes.
Cyclin D1-Cdk4 regulates neuronal activity through phosphorylation of GABAA receptors.
Title: Cyclin D1-Cdk4 regulates neuronal activity through phosphorylation of GABAA receptors.
USP13 deubiquitinates and stabilizes cyclin D1 to promote gastric cancer cell cycle progression and cell proliferation.
Title: USP13 deubiquitinates and stabilizes cyclin D1 to promote gastric cancer cell cycle progression and cell proliferation.
Circular RNA-AnnexinA7 accelerates cisplatin resistance in non-small cell lung cancer via modulating microRNA-545-3p to mediate Cyclin D1.
Title: Circular RNA-AnnexinA7 accelerates cisplatin resistance in non-small cell lung cancer via modulating microRNA-545-3p to mediate Cyclin D1.
EVI1 exerts distinct roles in AML via ERG and cyclin D1 promoting a chemoresistant and immune-suppressive environment.
Title: EVI1 exerts distinct roles in AML via ERG and cyclin D1 promoting a chemoresistant and immune-suppressive environment.
Cerebellar granule neurons induce Cyclin D1 before the onset of motor symptoms in Huntington's disease mice.
Title: Cerebellar granule neurons induce Cyclin D1 before the onset of motor symptoms in Huntington's disease mice.
Mir-4746 inhibits the proliferation of colorectal cancer cells in vitro and in vivo by targeting CCND1.
Title: Mir-4746 inhibits the proliferation of colorectal cancer cells in vitro and in vivo by targeting CCND1.
A synthetic mRNA cell reprogramming method using CYCLIN D1 promotes DNA repair, generating improved genetically stable human induced pluripotent stem cells.
Title: A synthetic mRNA cell reprogramming method using CYCLIN D1 promotes DNA repair, generating improved genetically stable human induced pluripotent stem cells.
Cyclin D1b induces changes in the macrophage phenotype resulting in promotion of tumor metastasis.
Title: Cyclin D1b induces changes in the macrophage phenotype resulting in promotion of tumor metastasis.

Submit: New GeneRIF Correction See all GeneRIFs (252)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (9) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC98458P1 (e-PCR)
- UniSTS:273670

PMC139749P3 (e-PCR)
- UniSTS:270890

NoName (e-PCR)
- UniSTS:235821

UniSTS:465472 (e-PCR)
- UniSTS:465472

Ccnd1 (e-PCR), detects polymorphism
- UniSTS:465472

PMC152277P1 (e-PCR)
- UniSTS:271212

NoName (e-PCR)
- UniSTS:548205

Ccnd1 (e-PCR), detects polymorphism
- UniSTS:531327

BI280117 (e-PCR)
- UniSTS:249021

Ccnd1 (e-PCR), detects polymorphism
- UniSTS:141255

Ccnd1 (e-PCR), detects polymorphism
- UniSTS:141256

PMC321442P2 (e-PCR)
- UniSTS:273110

AI327039 (e-PCR)
- UniSTS:179688

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables proline-rich region binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G1/S transition of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in G1/S transition of mitotic cell cycle	NAS Non-traceable Author Statement more info	PubMed
involved_in Leydig cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to organic substance	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within endoplasmic reticulum unfolded protein response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within lactation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within lactation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within liver regeneration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within mammary gland alveolus development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within mammary gland alveolus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of mammary gland epithelial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within mammary gland epithelial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitotic G1 DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of mammary gland epithelial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within re-entry into mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of G1/S transition of mitotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to UV-A	ISO Inferred from Sequence Orthology more info
involved_in response to leptin	ISO Inferred from Sequence Orthology more info
involved_in response to organonitrogen compound	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in bicellular tight junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
part_of cyclin D1-CDK4 complex	IPI Inferred from Physical Interaction more info	PubMed
part_of cyclin D1-CDK4 complex	ISO Inferred from Sequence Orthology more info
part_of cyclin-dependent protein kinase holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cyclin-dependent protein kinase holoenzyme complex	IPI Inferred from Physical Interaction more info	PubMed
part_of cyclin-dependent protein kinase holoenzyme complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription repressor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: G1/S-specific cyclin-D1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001379248.1 → NP_001366177.1 G1/S-specific cyclin-D1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC161763

UniProtKB/TrEMBL

Q3TC96

Conserved Domains (2) summary

cd20573
Location:3 → 151

CYCLIN_CCND1_rpt1; first cyclin box found in G1/S-specific cyclin-D1 (CCND1)

cd20576
Location:156 → 287

CYCLIN_CCND1_rpt2; second cyclin box found in G1/S-specific cyclin-D1 (CCND1)
NM_007631.3 → NP_031657.1 G1/S-specific cyclin-D1 isoform 2

See identical proteins and their annotated locations for NP_031657.1

Status: VALIDATED

Source sequence(s)

AC161763

Consensus CDS

CCDS22055.1

UniProtKB/Swiss-Prot

P25322

UniProtKB/TrEMBL

Q3TC96, Q790L7

Related

ENSMUSP00000091495.5, ENSMUST00000093962.5

Conserved Domains (2) summary

cd20573
Location:3 → 151

CYCLIN_CCND1_rpt1; first cyclin box found in G1/S-specific cyclin-D1 (CCND1)

cd20576
Location:156 → 265

CYCLIN_CCND1_rpt2; second cyclin box found in G1/S-specific cyclin-D1 (CCND1)