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Cckar cholecystokinin A receptor [ Mus musculus (house mouse) ]

Gene ID: 12425, updated on 30-Apr-2024

Summary

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Official Symbol
Cckarprovided by MGI
Official Full Name
cholecystokinin A receptorprovided by MGI
Primary source
MGI:MGI:99478
See related
Ensembl:ENSMUSG00000029193 AllianceGenome:MGI:99478
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable cholecystokinin receptor activity and peptide hormone binding activity. Acts upstream of or within axonogenesis; forebrain development; and neuron migration. Predicted to be located in several cellular components, including endosome; lysosome; and terminal bouton. Predicted to be integral component of plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; and respiratory system. Human ortholog(s) of this gene implicated in obesity. Orthologous to human CCKAR (cholecystokinin A receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 14.7), kidney adult (RPKM 12.1) and 4 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 C1; 5 29.52 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (53855827..53865046, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (53698485..53707704, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13086 Neighboring gene STARR-seq mESC enhancer starr_13089 Neighboring gene predicted gene, 40304 Neighboring gene STARR-seq mESC enhancer starr_13090 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:53980216-53980325 Neighboring gene recombination signal binding protein for immunoglobulin kappa J region Neighboring gene STARR-seq mESC enhancer starr_13092 Neighboring gene STARR-seq mESC enhancer starr_13095 Neighboring gene TBC1 domain family, member 19 Neighboring gene STARR-seq mESC enhancer starr_13097 Neighboring gene predicted gene, 40305

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cellular and subcellular localization of cholecystokinin (CCK)-1 receptors in the pancreas, gallbladder, and stomach of mice. Konno K, et al. Histochem Cell Biol, 2015 Mar. PMID 25249350
  2. Cholecystokinin: an excitatory modulator of mitral/tufted cells in the mouse olfactory bulb. Ma J, et al. PLoS One, 2013. PMID 23691163, Free PMC Article
  3. Comparison of the metabolic effects of sustained CCK1 receptor activation alone and in combination with upregulated leptin signalling in high-fat-fed mice. Irwin N, et al. Diabetologia, 2013 Jun. PMID 23462797
  4. Female mice lacking cholecystokinin 1 receptors have compromised neurogenesis, and fewer dopaminergic cells in the olfactory bulb. Sui Y, et al. Front Cell Neurosci, 2013. PMID 23459364, Free PMC Article
  5. Mechanisms of cholecystokinin-induced calcium mobilization in gastric antral interstitial cells of Cajal. Gong YY, et al. World J Gastroenterol, 2012 Dec 28. PMID 23326123, Free PMC Article

See all (87) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cholecystokinin Activation of Cholecystokinin 1 Receptors: a Purkinje Cell Neuroprotective Pathway.
    Title: Cholecystokinin Activation of Cholecystokinin 1 Receptors: a Purkinje Cell Neuroprotective Pathway.
  2. The studies establish chronic pancreatitis as an IL-33-dependent inflammation resulting from synergistic interactions between the NOD1 and CCKR signaling pathways.
    Title: Nucleotide-binding oligomerization domain 1 acts in concert with the cholecystokinin receptor agonist, cerulein, to induce IL-33-dependent chronic pancreatitis.
  3. There is functional synergy between cholecystokinin receptors CCKAR and CCKBR in mammalian brain development.
    Title: Functional synergy between cholecystokinin receptors CCKAR and CCKBR in mammalian brain development.
  4. mice lacking CCK receptors exhibited a functional shift from the gastrin-CCK pathways to the neuronal pathway in control of the ECL cells and eventually the acid secretion
    Title: Gene expression profiling of gastric mucosa in mice lacking CCK and gastrin receptors.
  5. cellular and subcellular localization of cholecystokinin (CCK)-1 receptors in the pancreas, gallbladder, and stomach
    Title: Cellular and subcellular localization of cholecystokinin (CCK)-1 receptors in the pancreas, gallbladder, and stomach of mice.
  6. The lithogenic diet was associated with significantly lower CAV3 in the liver and lower CAV3 and CCKAR in the gallbladder compared with the control mice.
    Title: Association of caveolin-3 and cholecystokinin A receptor with cholesterol gallstone disease in mice.
  7. CCK-8S increases [Ca(2+)]i in gastric antral interstitial cells of Cajal via the CCK(1) receptor
    Title: Mechanisms of cholecystokinin-induced calcium mobilization in gastric antral interstitial cells of Cajal.
  8. CCK1 receptor activation does not have a greater effect combination with upregulated leptin signalling in high-fat-fed mice
    Title: Comparison of the metabolic effects of sustained CCK1 receptor activation alone and in combination with upregulated leptin signalling in high-fat-fed mice.
  9. Suggest role for ependymal CCK-1 receptors in infant satiety-controlling mechanisms.
    Title: Infant satiety depends on transient expression of cholecystokinin-1 receptors on ependymal cells lining the third ventricle in mice.
  10. CCK-1 and -2 receptors may function synergistically in single PaPo neurons and deletion of CCK-1 receptors may facilitate CCK-2 receptor signaling.
    Title: Functional compensation between cholecystokinin-1 and -2 receptors in murine paraventricular nucleus neurons.
Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables cholecystokinin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cholecystokinin receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide hormone binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within axonogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cholecystokinin signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in eating behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in feeding behavior ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within forebrain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gastric acid secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in insulin secretion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of somatostatin secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in reduction of food intake in response to dietary excess ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of hormone secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of potassium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in response to starvation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in temperature homeostasis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in terminal bouton ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cholecystokinin receptor type A
Names
CCK-A receptor
CCK-AR
CCK1-R
cholecystokinin-1 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347354.1 → NP_001334283.1  cholecystokinin receptor type A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC084054, AC122196
    Consensus CDS
    CCDS84881.1
    UniProtKB/TrEMBL
    Q3TPL0
    Related
    ENSMUSP00000144103.2, ENSMUST00000200691.4

  2. NM_009827.2 → NP_033957.1  cholecystokinin receptor type A isoform 1

    See identical proteins and their annotated locations for NP_033957.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK004730, AK147052
    Consensus CDS
    CCDS19293.1
    UniProtKB/Swiss-Prot
    O08786, Q8VCC7, Q9DBV6
    Related
    ENSMUSP00000031093.4, ENSMUST00000031093.5
    Conserved Domains (3) summary
    pfam00001
    Location:58 → 378
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam09193
    Location:1 → 47
    CholecysA-Rec_N; Cholecystokinin A receptor, N-terminal
    cl21561
    Location:48 → 196
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    53855827..53865046 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08786.1 GenPept UniProtKB/Swiss-Prot:O08786

Gene LinkOut

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