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LTB4R leukotriene B4 receptor [ Homo sapiens (human) ]

Gene ID: 1241, updated on 11-Apr-2024

Summary

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Official Symbol
LTB4Rprovided by HGNC
Official Full Name
leukotriene B4 receptorprovided by HGNC
Primary source
HGNC:HGNC:6713
See related
Ensembl:ENSG00000213903 MIM:601531; AllianceGenome:HGNC:6713
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BLT1; BLTR; P2Y7; GPR16; LTBR1; P2RY7; CMKRL1; LTB4R1
Summary
Predicted to enable G protein-coupled peptide receptor activity and leukotriene B4 receptor activity. Predicted to be involved in inflammatory response and neuropeptide signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in skin (RPKM 33.9), esophagus (RPKM 9.6) and 10 other tissues See more
Orthologs
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Genomic context

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See LTB4R in Genome Data Viewer
Location:
14q12
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (24311502..24318036)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (18509845..18516371)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (24780708..24787242)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene NOP9 nucleolar protein Neighboring gene dehydrogenase/reductase 1 Neighboring gene nonconserved acetylation island sequence 81 enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5635 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5636 Neighboring gene cell death inducing DFFA like effector b Neighboring gene leukotriene B4 receptor 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:24785286-24785786 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:24790818-24791777 Neighboring gene adenylate cyclase 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5637 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5638 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5639 Neighboring gene Sharpr-MPRA regulatory region 10023 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8214 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8215 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8216 Neighboring gene receptor interacting serine/threonine kinase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Structural basis of leukotriene B4 receptor 1 activation. Wang N, et al. Nat Commun, 2022 Mar 3. PMID 35241677, Free PMC Article
  2. Structural insights on ligand recognition at the human leukotriene B4 receptor 1. Michaelian N, et al. Nat Commun, 2021 May 20. PMID 34016973, Free PMC Article
  3. The role of the LTB4-BLT1 axis in health and disease. He R, et al. Pharmacol Res, 2020 Aug. PMID 32439596
  4. BLT1-mediated O-GlcNAcylation is required for NOX2-dependent migration, exocytotic degranulation and IL-8 release of human mast cell induced by Trichomonas vaginalis-secreted LTB(4). Min A, et al. Microbes Infect, 2018 Jun-Jul. PMID 29859938
  5. Na(+)-mimicking ligands stabilize the inactive state of leukotriene B(4) receptor BLT1. Hori T, et al. Nat Chem Biol, 2018 Mar. PMID 29309055

See all (79) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural basis of leukotriene B4 receptor 1 activation.
    Title: Structural basis of leukotriene B4 receptor 1 activation.
  2. SPM Receptor Expression and Localization in Irradiated Salivary Glands.
    Title: SPM Receptor Expression and Localization in Irradiated Salivary Glands.
  3. Structural insights on ligand recognition at the human leukotriene B4 receptor 1.
    Title: Structural insights on ligand recognition at the human leukotriene B4 receptor 1.
  4. The role of the LTB4-BLT1 axis in health and disease.
    Title: The role of the LTB4-BLT1 axis in health and disease.
  5. A regulatory role of scavenger receptor class B type 1 in endocytosis and lipid droplet formation induced by liposomes containing phosphatidylethanolamine in HEK293T cells.
    Title: A regulatory role of scavenger receptor class B type 1 in endocytosis and lipid droplet formation induced by liposomes containing phosphatidylethanolamine in HEK293T cells.
  6. Individuals with nodules showed significantly higher levels of TxB2 and LTB4 than healthy controls, whereas significant differences in LTB4 levels were observed between individuals with unencapsulated dirofilariosis worms and healthy controls.
    Title: A possible relationship between Thromboxane B2 and Leukotriene B4 and the encapsulation of Dirofilaria repens worms in human subcutaneous dirofilariasis.
  7. Trichomonas vaginalis-derived secretory products (TvSP) induces protein O-GlcNAcylation and O-GlcNAc transferase (OGT) expression in mast cells, which is prevented by LTB4 receptor (BLT1) siRNA. TvSP-induced migration, ROS generation, and IL-8 release are suppressed by OGT inhibitor or OGT siRNA. These results suggest that BLT1-mediated OGlcNAcylation is important for mast cell activation during trichomoniasis.
    Title: BLT1-mediated O-GlcNAcylation is required for NOX2-dependent migration, exocytotic degranulation and IL-8 release of human mast cell induced by Trichomonas vaginalis-secreted LTB(4).
  8. analysis of leukotriene B4 (LTB4) receptor BLT1 bound with BIIL260, a chemical bearing a benzamidine moiety, reveals that it is fixed in the inactive state, and the transmembrane helices cannot change their conformations to form the active state
    Title: Na(+)-mimicking ligands stabilize the inactive state of leukotriene B(4) receptor BLT1.
  9. fact, leukotriene B4 (LTB4) is an eicosanoid lipid derivative of arachidonic acid, which primarily binds itself to the high-affinity G protein-coupled receptor BLT1. BLT1 plays an indispensable role in atherosclerosis. Hence, the BLT1 antagonist might have a therapeutic role in treating atherosclerosis. [review]
    Title: BLT1: a promising therapeutic approach for atherosclerosis.
  10. A novel regulatory mechanism for SNAP23-dependent mast cell activation of T. vaginalis-secreted LTB4 involving surface trafficking of BLT1.
    Title: SNAP23-Dependent Surface Translocation of Leukotriene B4 (LTB4) Receptor 1 Is Essential for NOX2-Mediated Exocytotic Degranulation in Human Mast Cells Induced by Trichomonas vaginalis-Secreted LTB4.
Submit: New GeneRIF Correction See all GeneRIFs (58)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association analyses of child genotype effects and parent-of-origin effects in specific language impairment.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables leukotriene B4 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables leukotriene receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables nucleotide binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in immune response TAS
Traceable Author Statement
more info
 PubMed 
involved_in leukotriene signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in muscle contraction TAS
Traceable Author Statement
more info
 PubMed 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
leukotriene B4 receptor 1
Names
G protein-coupled receptor 16
LTB4-R 1
LTB4-R1
P2Y purinoceptor 7
chemoattractant receptor-like 1
chemokine receptor-like 1
purinergic receptor P2Y, G-protein coupled, 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143919.3 → NP_001137391.1  leukotriene B4 receptor 1

    See identical proteins and their annotated locations for NP_001137391.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AL096870, BQ182452, D89079
    Consensus CDS
    CCDS9626.1
    UniProtKB/Swiss-Prot
    Q13305, Q15722, Q53XV5, Q92641, Q9BSU5
    Related
    ENSP00000307445.3, ENST00000345363.8
    Conserved Domains (1) summary
    pfam00001
    Location:35 → 285
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  2. NM_181657.3 → NP_858043.1  leukotriene B4 receptor 1

    See identical proteins and their annotated locations for NP_858043.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AL096870, BQ182452
    Consensus CDS
    CCDS9626.1
    UniProtKB/Swiss-Prot
    Q13305, Q15722, Q53XV5, Q92641, Q9BSU5
    Related
    ENSP00000380008.4, ENST00000396789.4
    Conserved Domains (1) summary
    pfam00001
    Location:35 → 285
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    24311502..24318036
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654722.1 Reference GRCh38.p14 PATCHES

    Range
    612480..619014
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    18509845..18516371
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15722.2 GenPept UniProtKB/Swiss-Prot:Q15722

Gene LinkOut

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